Zobrazeno 1 - 10
of 31
pro vyhledávání: '"J. F. REINDEL"'
Autor:
D. L. Hutto, Prachi Sharma, Heather A. Simmons, Richard J. Montali, S. Cummings Macri, M. Owston, A. Bradley, Shiva Kumar Shanmukhappa, Saravanan Kaliyaperumal, Keith Mansfield, Lisa M. Kattenhorn, E. Gruber-Dujardin, Linda J. Lowenstine, D. Liu, Basel T. Assaf, Andrew D. Miller, Martha A. Delaney, Kerstin Mätz-Rensing, C. Tremblay, L. D. Schmidt, J. F. Reindel, Audrey Baldessari, Karen A. Terio, J. E. Markovits, Joseph L. Mankowski, J. M. Cline, Vito G. Sasseville, Cynthia L. Courtney, Carole Harbison
Publikováno v:
Veterinary Pathology. 49:1057-1069
The combination of loss of habitat, human population encroachment, and increased demand of select nonhuman primates for biomedical research has significantly affected populations. There remains a need for knowledge and expertise in understanding back
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b0b9f5f7f7da93f438f50f0a91b8a1
https://doi.org/10.1177/0300985812461655
https://doi.org/10.1177/0300985812461655
Publikováno v:
Toxicological Sciences. 62:80-91
To assess effects of supraphysiologic doses of human recombinant epidermal growth factor(1-48) (rhEGF(1-48)) on neonatal rats, 10 litters of Wistar rats/treatment group were given 0 (formulated vehicle), 10, 100, or 1000 microg/kg daily by subcutaneo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a663e1b6215ad43cf4043f8ce13eed
https://doi.org/10.1093/toxsci/62.1.80
https://doi.org/10.1093/toxsci/62.1.80
Autor:
J. F. Reindel, Gregg Sobocinski, Alexander W. Gough, Gary D. Pilcher, Walter F. Bobrowski, Felix A. de la Iglesia
Publikováno v:
Toxicologic Pathology. 29:159-173
Epidermal growth factor (EGF) effects have been explored extensively in vivo in rodents, but little is known about trophic responses in nonhuman primates. A previous publication reports the hyperplastic epithelial/parenchymal changes noted in the dig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1df87bb26da9831425c8da12361becb
https://doi.org/10.1080/019262301317052431
https://doi.org/10.1080/019262301317052431
Autor:
A. L. Fitzgerald, Andre Dubois, J. F. Reindel, J. V. Mysore, A. W. Gough, M. A. Breider, C. Yan
Publikováno v:
Veterinary Pathology. 36:1-13
An epizootic of subclinical lymphoplasmacytic gastritis occurred in cynomolgus monkeys maintained at our research facility. Gastric pathology data and histologic sections of 63 adolescent monkeys (2.5-3.5 years old) sacrificed during the epizootic we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482b426284ad20d03b56160ecb77f788
https://doi.org/10.1354/vp.36-1-1
https://doi.org/10.1354/vp.36-1-1
Autor:
Maureen K. Anderson, Andrew D. White, Thomas M.A. Bocan, R. F. Bousley, Claude Forsey Purchase, Sandra Bak Mueller, Brian R. Krause, Peter Lee, J. F. Reindel, Reynold Homan, R. L. Stanfield, K. L. Hamelehle, Cecilia Speyer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1753-1758
A novel series of tetrazole-substituted ureas 2 were prepared from weakly nucleophilic amines using a new coupling method. The ureas were found to potently inhibit liver ACAT in vitro and lower total serum cholesterol in vivo. A comparison of urea 2b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19c77c667fa12975e42e0099ca9943ab
https://doi.org/10.1016/0960-894x(96)00310-1
https://doi.org/10.1016/0960-894x(96)00310-1
Publikováno v:
Veterinary Pathology. 33:184-194
In this study, we determined in vivo morphologic effects of continuous intravenous infusion of recombinant human epidermal growth factor (EGF) in adult Wistar rats. The EGF used consisted of the amino acid residues 1-48 of the human 53-amino-acid EGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6ef24959a9413b5c06b74bdc4613eb
https://doi.org/10.1177/030098589603300208
https://doi.org/10.1177/030098589603300208
Autor:
Drago Sliskovic, Essenburg Ad, Joseph Armand Picard, J. F. Reindel, L. L. Minton, B.R. Krause, R. L. Stanfield, W. H. Roark
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:713-718
The synthesis and structure-activity relationships of a series of malonester amide ACAT inhibitors are described. One of these compounds, 4s , was shown to be a potent inhibitor of both the intestinal and arterial enzymes, bioactive upon oral dosing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91f0d88d43a22709606ea47b4b323690
https://doi.org/10.1016/0960-894x(96)00098-4
https://doi.org/10.1016/0960-894x(96)00098-4
Autor:
Maureen K. Anderson, Patrice Lee, J. F. Reindel, K. L. Hamelehle, R. L. Stanfield, Drago Sliskovic, J. A. Picard, Bruce D. Roth, B.R. Krause, D. Turluck, Andrew D. White, Sandra Bak Mueller, Reynold Homan, Thomas M.A. Bocan, Patrick Michael O'brien, Helen Tsenwhei Lee, Claude Forsey Purchase, R. F. Bousley
Publikováno v:
Journal of Medicinal Chemistry. 39:2354-2366
A series of tetrazole amide derivatives of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide (1) was prepared and evaluated for their ability to inhibit acyl-CoA: cholesterol O-acyltransferase (ACAT) in vitro and to lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50d87ec1d2a4e896eabf54421ba52bd
https://doi.org/10.1021/jm960170f
https://doi.org/10.1021/jm960170f
Toxicologic Effects of a Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor in Cynomolgus Monkeys
Publikováno v:
Toxicologic Pathology. 22:510-518
PD 132301-2, an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, was administered orally to cynomolgus monkeys for 2 wk at doses of 25, 50, 100, and 200 mg/kg to assess potential subacute toxicity. Sporadic episodes of soft feces and diarrhea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1814250a998822afa8140fe7144623
https://doi.org/10.1177/019262339402200505
https://doi.org/10.1177/019262339402200505
Autor:
A. W. Gough, Walter F. Bobrowski, Thomas M.A. Bocan, E. J. Mcguire, J. F. Reindel, Mark A. Dominick
Publikováno v:
Fundamental and Applied Toxicology. 20:217-224
Subacute Toxicity of a Novel Inhibitor of Acyl-CoA:Cholesterol Acyltransferase in Beagle Dogs. Dominick, M. A., McGuire, E. J., Reindel, J. F., Bobrowski, W. F., Bocan, T. M. A., and Gough, A. W. (1993). Fundam. Appl. Toxicol. 20, 217-224. PD 132301-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8e3f5a25a2fa58f644da10b2148ef1
https://doi.org/10.1006/faat.1993.1029
https://doi.org/10.1006/faat.1993.1029