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Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Autor: Christine J. F. Nielsen, Kurt V. Gothelf, J. Simon C. Arthur, Erik Daa Funder, Helle Gotfred-Rasmussen, Jacob Andersen, Poul Nissen, Mads Kirchheiner Rasmussen, Borbala Gesser, Rachel Toth, Lars Iversen

Publikováno v: Andersen, J L, Gesser, B, Funder, E D, Nielsen, C J F, Gotfred-Rasmussen, H, Rasmussen, M K, Toth, R, Gothelf, K V, Arthur, J S C, Iversen, L & Nissen, P 2018, ' Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases ', Nature Communications, vol. 9, no. 1, 4344 . https://doi.org/10.1038/s41467-018-06787-w
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)

Dimethyl fumarate (DMF) has been applied for decades in the treatment of psoriasis and now also multiple sclerosis. However, the mechanism of action has remained obscure and involves high dose over long time of this small, reactive compound implicati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a8b9f1ef81620ab1ee814f6c2f8a1b
https://pure.au.dk/portal/da/publications/dimethyl-fumarate-is-an-allosteric-covalent-inhibitor-of-the-p90-ribosomal-s6-kinases(ff27ac53-9409-4678-aaee-a1e66d966606).html

Using fourier velocity encoded MRI data to guide CFD simulations

Autor: Krishna S. Nayak, Joao L. A. Carvalho, J.-F. Nielsen, Vinicius Carvalho Rispoli

Publikováno v: ISBI

Fourier velocity encoding (FVE) is a promising magnetic resonance imaging (MRI) method for assessment of cardiovascular blood flow. FVE provides considerably higher signal-to-noise ratio than phase contrast (PC) imaging, is robust to partial-volume e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::638e477a43b0c36f615ea2327866b857
https://doi.org/10.1109/isbi.2015.7163941

Scanning tunneling microscope studies of boron-doped Si(001)

Autor: J. F. Nielsen, Jonathan P. Pelz, Michael Krueger, H. J. Im, Eric Ganz, Brian Borovsky

Publikováno v: Scopus-Elsevier

We have used scanning tunneling microscopy (STM) and Auger electron spectroscopy to characterize B/Si(001) surface structures and the dependence of their density and location on high-temperature annealing. While annealing of heavily B-doped Si(001) s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fc9d1dc76d11b29dbf2fdad3254ab4
https://doi.org/10.1116/1.581870