Zobrazeno 1 - 10 of 47 pro vyhledávání: '"J. F. Newton"'
2
Bicyclic N-Hydroxyurea Inhibitors of 5-Lipoxygenase: Pharmacodynamic, Pharmacokinetic, and in Vitro Metabolic Studies Characterizing N-Hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea
Autor: William Brian, Eric Garver, Margaret E. Sorenson, Edward F. Webb, Don E. Griswold, Ravi Shanker Garigipati, Jerry L. Adams, Marie Chabot-Fletcher, Schmidt Stanley J, J F Newton, M. N. Tzimas, Lee Ann P. Yodis, John J. Breton, Kathy A. Tyrrell
Publikováno v: Journal of Medicinal Chemistry. 39:5035-5046
A series of N-hydroxyurea derivatives have been prepared and examined as inhibitors of 5-lipoxygenase. Oral activity was established by examining the inhibition of LTB4 biosynthesis in an ex vivo assay in the mouse. The pharmacodynamic performance in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4747a24081182d48db64046b99fccc9e
https://doi.org/10.1021/jm960271d
Zobrazit plný text záznamu
4
Pharmacology of the pyrroloimidazole, SK&F 105809—I
Autor: Edward F. Webb, Don E. Griswold, Nabil Hanna, John J. Breton, L. M. Hillegass, John C. Lee, J F Newton, Paul J. Marshall, Paul Elliot Bender, Henry M. Sarau
Publikováno v: Biochemical Pharmacology. 42:813-824
SK&F 105809 {2-(4- methylsulfinylphenyl )-3-(4- pyridyl )-6,7- dihydro -[5H]- pyrrolo [l,2-a] imidazole} was determined to be a prodrug for the sulfide metabolite SK&F 105561 {2-(4- methyltniophenyl )-3-(4- pyridyl )-6,7- dihydro -[5H]- pyrrolo [1,2-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88801236a18f75eacfe53b9274845b6c
https://doi.org/10.1016/0006-2952(91)90041-3
Zobrazit plný text záznamu
5
Pharmacology of the pyrroloimidazole, SK&F 105809—II
Autor: Jill Wartell, John C. Lee, Don E. Griswold, L. M. Hillegass, Edward F. Webb, J F Newton, Paul J. Marshall, Nabil Hanna
Publikováno v: Biochemical Pharmacology. 42:825-831
SK&F 105809 [2-(4-methylsulfinylphenyl)-3-(4-pyridyl)- 6,7-dihydro-[5H]-pyrrolo[1,2,a] imidazole] demonstrated unique antiinflammatory activities in murine models that are resistant to selective cyclooxygenase (CO) inhibitors. Both edema and inflamma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e4f94f5bbd3084bce4ed8be37b8a4af
https://doi.org/10.1016/0006-2952(91)90042-4
Zobrazit plný text záznamu
6
Comparative Biochemical and Morphometric Changes Associated with Induction of the Hepatic Mixed Function Oxidase System in the Rat
Autor: John R. Ventre, Lester W. Schwartz, J F Newton, Monica O. Howard, Charles W. Qualls, Lee Ann P. Yodis
Publikováno v: Toxicologic Pathology. 19:115-122
This study characterized the induction of the rat hepatic cytochrome P-450-dependent mixed function oxidase system by SK & F 86002 [6-(4'-fluorophenyl)-5-(4'-pyridyl)-2,3-dihydroimidazo-(2,1-b)thiazole], an inhibitor of both the cyclooxygenase and 5-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3288a691afd6b520d019ef7180d24d
https://doi.org/10.1177/019262339101900205
Zobrazit plný text záznamu
7
Pharmacologic and pharmacokinetic profile of SK&F S-106203, a potent, orally active peptidoleukotriene receptor antagonist, in guinea-pig
Autor: L. Vickery-Clark, R.M. Muccitelli, R.D. Eckardt, L.-A.P. Yodis, Henry M. Sarau, M.A. Wasserman, C.M. Saverino, John G. Gleason, T. J. Torphy, R.R. Osborn, J. F. Newton, L.S. Novak, D.W.P. Hay
Publikováno v: Pulmonary Pharmacology. 4:177-189
In this report the pharmacologic and pharmacokinetic profile of the leukotriene receptor antagonist 3(S)-[(2-carboxyethyl)thio]-3-[2-(8-phenyloctyl)phenyl] propanoic acid (SKF S-106203) in guinea-pigs is described. In isolated guinea-pig tracheae SKF
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b92bc157e3aa17bcaebad9896d76745
https://doi.org/10.1016/0952-0600(91)90009-r
Zobrazit plný text záznamu
8
Metabolism of the leukotriene receptor antagonist 5-(2-(8-phenyloctyl)phenyl)-4,6-dithianonanedioic acid (SKF 102922) in the guinea pig. Rearrangement of the acyl glucuronide
Autor: J F, Newton, K M, Straub, R H, Dewey, C D, Perchonock, M E, McCarthy, J G, Gleason, R K, Lynn
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 20(4)
A primary route of inactivation of leukotrienes and their receptor antagonists (LTRA) is metabolism by omega oxidation. SKF 102922 [5-(2-(8-phenyloctyl)phenyl)-4,6-dithianonanedioic acid] is a LTRA that was designed to be resistant to omega oxidation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb871c7d2e5913da97e6877f87314aba
https://pubmed.ncbi.nlm.nih.gov/1356721
Zobrazit plný text záznamu
10
In vitro metabolism of the novel antiinflammatory agent 6-(4'-fluorophenyl)-5-(4'-pyridyl)-2,3-dihydroimidazo-[2,1-b]-thiazole
Autor: M O, Howard, J F, Newton, D J, Keohane, L P, Yodis, C M, Saverino, C W, Qualls, L W, Schwartz
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 18(5)
6-(4'-Fluorophenyl)-5-(4'-pyridyl)-2,3-dihydroimidazo-[2,1-b]-thia zole (SKF 86002) is a dual inhibitor of arachidonic acid metabolism which has therapeutic potential for the treatment of inflammatory diseases. Previous studies in rats, in vivo, demo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b088ad63dd9e93ae320888eb1df4ef7
https://pubmed.ncbi.nlm.nih.gov/1981708
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje