Zobrazeno 1 - 10
of 148
pro vyhledávání: '"J. F. King"'
Autor:
Ahmed A. Arzouni, Andreia Vargas‐Seymour, Paramjeet K. Dhadda, Chloe L. Rackham, Guo‐Cai Huang, Pratik Choudhary, Aileen J. F. King, Peter M. Jones
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 9, Pp 935-944 (2019)
Abstract Islet transplantation has the potential to cure type 1 diabetes, but current transplantation protocols are not optimal and there is extensive loss of islet β‐cell insulin secretory function during the immediate post‐transplantation peri
Externí odkaz:
https://doaj.org/article/832864f4082d47ec8e7ec4256c169630
Autor:
Lydia F. Daniels Gatward, Yujin Kim, Aerin Loe, Yiyang Liu, Line Kristensen, Aileen J. F. King
Publikováno v:
Diabetic medicine : a journal of the British Diabetic AssociationREFERENCES. 39(12)
Beta cell endoplasmic reticulum (ER) stress can cause cellular death and dysfunction and has been implicated in the pathogenesis of diabetes. Animal models of beta cell ER stress are critical in further understanding this and for testing novel diabet
Publikováno v:
Cell Transplantation, Vol 26 (2017)
Externí odkaz:
https://doaj.org/article/b706b14b64d8434dbec4bf459531c792
Autor:
Aileen J. F. King, Peter Jones, Stuart Bevan, Clive Gentry, Sally Sharp, David Andersson, Gabriel Santos, Miriam Cnop, Lydia F. Daniels Gatward, Amazon L.F. Austin, Ada Admin
Animal models are important tools in diabetes research as ethical and logistical constraints limit access to human tissue. Beta cell dysfunction is a common contributor to the pathogenesis of most types of diabetes. Spontaneous hyperglycaemia develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630d138e1f17fae25beff6f56a9c05dd
https://doi.org/10.2337/figshare.12990821.v1
https://doi.org/10.2337/figshare.12990821.v1
Autor:
Aileen J F King, Yongjing Guo, Dongsheng Cai, Jennifer Hollister-Lock, Brooke Morris, Alison Salvatori, John A Corbett, Susan Bonner-Weir, Steven E Shoelson, Gordon C Weir
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77452 (2013)
The activation of the transcription factor NF-κB leads to changes in expression of many genes in pancreatic β-cells. However, the role of NF-κB activation in islet transplantation has not been fully elucidated. The aim of the present study was to
Externí odkaz:
https://doaj.org/article/342a868255eb493da4e9de391aaf79a3
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57844 (2013)
We have previously shown that co-transplantation of islets and Mesenchymal Stem Cells (MSCs) improves islet graft function and revascularisation, which was associated with the maintenance of normal islet morphology. The aim of the current study was t
Externí odkaz:
https://doaj.org/article/aa44c229544d4413875d534d814d501d
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2128
Measurement of blood glucose concentration is a common end point in studies using animal models of diabetes. Usually a blood glucose meter is used to measure non-fasted blood glucose concentrations, typically at frequencies of between 1 and 7 times p
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2128
Mouse models of diabetes are important tools used in preclinical diabetes research. However, when working with these models, it is important to consider factors that could influence experimental outcome. This is particularly important given the wide
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2128
Streptozotocin (STZ) selectively destroys beta cells and is widely used to induce experimental diabetes in rodents. Rodent beta cells are very sensitive to the toxic effects of STZ, while human beta cells are highly resistant to STZ. Taking advantage
Autor:
Aileen J F, King, Chloe L, Rackham
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2076
Islet transplantation is a potential treatment for Type 1 diabetes; however, improvements need to be made before it could become clinically widely available. In preclinical studies, the mouse is often used to model islet transplantation, with most st