Zobrazeno 1 - 10
of 47
pro vyhledávání: '"J. F. Desnottes"'
Autor:
J.-F. Desnottes
Publikováno v:
Antibiotiques. 11:e1-e12
Resume Introduction Pendant des decennies, la recherche antibacterienne a ete essentiellement focalisee sur le developpement de molecules a activite bacteriostatique et bactericide. Cette strategie basee sur la recherche de nouvelles cibles bacterien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2344b0f451fe08b0bbf4bf13427f2ffb
https://doi.org/10.1016/j.antib.2009.02.004
https://doi.org/10.1016/j.antib.2009.02.004
Autor:
J F Desnottes, Francis Blanche, Joel Crouzet, S Sablé, J Provost, Béatrice Cameron, F X Bernard
Publikováno v:
Antimicrobial Agents and Chemotherapy. 41:992-998
Three flavonoids which promoted Escherichia coli topoisomerase IV-dependent DNA cleavage were isolated from cottonseed flour and identified as quercetin 3-O-beta-D-glucose-[1,6]-O-alpha-L-rhamnose (rutin), quercetin 3-O-beta-D-galactose-[1,6]-O-alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baf2c26d08fc6281cb62c64cea9595f
https://doi.org/10.1128/aac.41.5.992
https://doi.org/10.1128/aac.41.5.992
Autor:
J. F. Desnottes
Publikováno v:
Trends in Biotechnology. 14:134-140
The increasing incidence of bacterial drug-resistance is stimulating the development of strategies targeting previously unexploited mechanisms of antibiotic action. Combinatorial chemistry, which generates molecularly diverse compounds, target-direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d7fc5097a121a1bb237365f703f0b4
https://doi.org/10.1016/0167-7799(96)10015-9
https://doi.org/10.1016/0167-7799(96)10015-9
Bactericidal activity and kinetics of RP 59500 in a mouse model of Staphylococcus aureus septicaemia
Publikováno v:
Journal of Antimicrobial Chemotherapy. 36:365-373
The bactericidal activity of RP 59500, a semisynthetic streptogramin, was compared with that of vancomycin against Staphylococcus aureus. This activity was evaluated in vitro by the kill curve method and in vivo using a model of mouse septicaemia. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d85444bb35d208ed635c02b2288256
https://doi.org/10.1093/jac/36.2.365
https://doi.org/10.1093/jac/36.2.365
Autor:
J. F. Desnottes, N. Diallo
Publikováno v:
Journal of Antimicrobial Chemotherapy. 33:737-746
We investigated the effect of sparfloxacin, a new broad-spectrum fluoroquinolone, on the morphology, adhesiveness and phagocytosis of a clinical isolate of Staphylococcus aureus sensitive to this compound (MIC = 0.06 mg/L). The strain was tested for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0015fbfe8e619c5a2f895b02fcd36f74
https://doi.org/10.1093/jac/33.4.737
https://doi.org/10.1093/jac/33.4.737
Autor:
Perrin Fayolle M, G. Panteix, J. F. Desnottes, M. Leclercq, R. Harf, Couprie N, Ballereau M, A. Desbos, Gosselet H, N. Diallo
Publikováno v:
Journal of Antimicrobial Chemotherapy. 33:979-985
The in-vivo pulmonary disposition of pefloxacin in alveolar macrophages alveolar macrophages and in the alveolar epithelial lining fluid recovered by bronchoalveolar lavage was studied in 10 healthy volunteers. Bronchoalveolar lavage was performed ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615c6cf1a6c9e3400cff07218c1f9b38
https://doi.org/10.1093/jac/33.5.979
https://doi.org/10.1093/jac/33.5.979
Publikováno v:
Journal of Antimicrobial Chemotherapy. 31:37-45
The effect of sub-inhibitory concentrations of antibacterials, including quinolones, on the surface properties of a uropathogenic strain of Escherichia coli was examined. The effect on the charge and hydrophobicity of the cell surface was assessed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2cdb1a6ba330bb8d979d0d7f321354
https://doi.org/10.1093/jac/31.1.37
https://doi.org/10.1093/jac/31.1.37
Publikováno v:
ChemInform. 29
The streptogramins are a class of antibiotics remarkable for their antibacterial activity and their unique mechanism of action. These antibiotics are produced naturally, but the therapeutic use of the natural compounds is limited because they do not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0203047b313aaaca90977d9b746cb02f
https://doi.org/10.1002/chin.199827347
https://doi.org/10.1002/chin.199827347
Publikováno v:
Journal of Antimicrobial Chemotherapy. 27:355-360
Six healthy adult volunteers were treated with 1 g of oral spiramycin twice daily for five days, and their oral and faecal microbial flora were studied. Mean saliva and serum concentrations of the antibiotic never exceeded 2.1 +/- 1.1 mg/l. The numbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64b5d86e9832f7007df9869f6e76b82
https://doi.org/10.1093/jac/27.3.355
https://doi.org/10.1093/jac/27.3.355
Publikováno v:
Journal of Antimicrobial Chemotherapy. 26:27-39
Pefloxacin, like other fluoroquinolones, accumulates in macrophages and several other types of nucleated cells (but not in erythrocytes). Upon fractionation of macrophage homogenates by isopycnic centrifugation in sucrose gradients, fluoroquinolones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db88b1ab6b0d415c07d2cc54967f2911
https://doi.org/10.1093/jac/26.suppl_b.27
https://doi.org/10.1093/jac/26.suppl_b.27