Real-Time Observation of Protein Aggregation at Liquid-Liquid Interfaces in a Microfluidic Device.

Autor: Zürcher D; ETH Zürich, Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Zürich, 8093, Switzerland., Wuchner K; Cilag GmbH International, a division of Johnson & Johnson, TDS-Biologics, Analytical Development, Schaffhausen, 8200, Switzerland., Arosio P; ETH Zürich, Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Zürich, 8093, Switzerland.

Publikováno v: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Nov; Vol. 20 (45), pp. e2401085. Date of Electronic Publication: 2024 Aug 22.

ChemInform Abstract: Interactions of Stabilizers with Proteins During Freezing and Drying

Autor: S. J. Prestrelski, T. J. Anchordoguy, J. F. Carpenter, T. Arakawa

Publikováno v: ChemInform. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcd5ed4f4fc98847e6c2bea19d01a806
https://doi.org/10.1002/chin.199504316

Development and Validation of a Headspace GC-MS Method for Simultaneous Quantification of Antimicrobial Preservatives in Biopharmaceutical Peptide Formulations.

Autor: Selaya SD; Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Pharmaceutical Quality Research, Food and Drug Administration, Silver Spring, Maryland, USA., Abrigo N; Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Pharmaceutical Quality Research, Food and Drug Administration, Silver Spring, Maryland, USA., Jones C; Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Pharmaceutical Quality Research, Food and Drug Administration, Silver Spring, Maryland, USA., Korang-Yeboah M; Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Pharmaceutical Quality Research, Food and Drug Administration, Silver Spring, Maryland, USA., Faustino PJ; Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Pharmaceutical Quality Research, Food and Drug Administration, Silver Spring, Maryland, USA., Shakleya D; Center for Drug Evaluation and Research, Office of Pharmaceutical Quality, Office of Pharmaceutical Quality Research, Food and Drug Administration, Silver Spring, Maryland, USA.

Publikováno v: Biomedical chromatography : BMC [Biomed Chromatogr] 2025 Jan; Vol. 39 (1), pp. e6045. Date of Electronic Publication: 2024 Nov 19.

High pressure refolding of recombinant human growth hormone from insoluble aggregates. Structural transformations, kinetic barriers, and energetics

Autor: R J, St John, J F, Carpenter, C, Balny, T W, Randolph

Publikováno v: The Journal of biological chemistry. 276(50)

Two different types of insoluble, non-native aggregates of recombinant human growth hormone were formed by agitation in buffer or buffer containing 0.75 m guanidine HCl (GdnHCl) and characterized by infrared and second derivative UV spectroscopies. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74442608df4eb0c13a6c4842d5b56bbc
https://pubmed.ncbi.nlm.nih.gov/11591710

Stability of human serum albumin during bioprocessing: denaturation and aggregation during processing of albumin paste

Autor: J J, Lin, J D, Meyer, J F, Carpenter, M C, Manning

Publikováno v: Pharmaceutical research. 17(4)

To assess the impact of various bioprocessing steps on the stability of freshly precipitated human serum albumin (HSA) obtained from pooled human plasma.After initial precipitation of HSA from plasma, the resultant paste is either (a) lyophilized or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f45423e1fcc6b046a2f4de44e70a43b
https://pubmed.ncbi.nlm.nih.gov/10870981