Výsledky vyhledávání - "J. F. Bowyer"

Long-term effects of amphetamine neurotoxicity on tyrosine hydroxylase mRNA and protein in aged rats

Autor: J F, Bowyer, L T, Frame, P, Clausing, K, Nagamoto-Combs, C A, Osterhout, C R, Sterling, A W, Tank

Publikováno v: The Journal of pharmacology and experimental therapeutics. 286(2)

Four injections (intraperitoneal) of 3 mg/kg amphetamine (2 hr apart) produced pronounced hyperthermia and sustained decreases in dopamine levels and tyrosine hydroxylase (TH) protein levels in the striatum of 15-month-old male rats. A partial recove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::776d823c1b896965cc9933ec06f65c4f
https://pubmed.ncbi.nlm.nih.gov/9694971

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Fenfluramine and norfenfluramine levels in brain microdialysate, brain tissue and plasma of rats administered doses of d-fenfluramine known to deplete 5-hydroxytryptamine levels in brain

Autor: P, Clausing, G D, Newport, J F, Bowyer

Publikováno v: The Journal of pharmacology and experimental therapeutics. 284(2)

The relationship between dose, frontal cortex (brain) microdialysate and brain tissue levels of fenfluramine (FEN) and norfenfluramine (NF), as well as the effect that these levels have on body temperature, was determined after systemic d-FEN. FEN an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6a2f5083b1310fc55ccce7c3c1a1e9e
https://pubmed.ncbi.nlm.nih.gov/9454806

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Elevated environmental temperatures can induce hyperthermia during d-fenfluramine exposure and enhance 5-hydroxytryptamine (5-HT) depletion in the brain

Autor: C W, Stewart, J F, Bowyer, W, Slikker

Publikováno v: The Journal of pharmacology and experimental therapeutics. 283(3)

d-Fenfluramine (d-Fen) has been demonstrated to alter body temperature (BT), decrease 5-hydroxytryptamine (5-HT) and decrease 5-HT plasma membrane transporters (PMT) in rats. Therefore, experiments were designed to test whether a correlation existed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e7b228bd5c1da4ef7bd7c038c125c9f
https://pubmed.ncbi.nlm.nih.gov/9399987

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Individual differences in dopamine release but not rotational behavior correlate with extracellular amphetamine levels in caudate putamen in unlesioned rats

Autor: P, Clausing, D, Bloom, G D, Newport, R R, Holson, W, Slikker, J F, Bowyer

Publikováno v: Psychopharmacology. 127(3)

It has been postulated that differences in pharmacokinetics do not contribute to the well-known individual variability in response to amphetamine (AMPH), but this is yet to be investigated thoroughly. Therefore, rotational behavior of outbred rats (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::48fd066d63d791521d106ec2f196ee16
https://pubmed.ncbi.nlm.nih.gov/8912396

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Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response

Autor: H W, Broening, J F, Bowyer, W, Slikker

Publikováno v: The Journal of pharmacology and experimental therapeutics. 275(1)

The effects of developmental age on (+/-)-3,4-methylenedioxymethamphetamine (MDMA)-induced reductions in 5-hydroxytryptamine (5-HT) content and 5-HT reuptake sites were investigated in conjunction with the effects of developmental age on MDMA-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64313bb649f0be28c432f0c3b742ad96
https://pubmed.ncbi.nlm.nih.gov/7562567

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Further studies of the role of hyperthermia in methamphetamine neurotoxicity

Autor: J F, Bowyer, D L, Davies, L, Schmued, H W, Broening, G D, Newport, W, Slikker, R R, Holson

Publikováno v: The Journal of pharmacology and experimental therapeutics. 268(3)

The depletion of striatal dopamine (DA) that can occur after methamphetamine (METH) administration has been linked to METH-induced hyperthermia. The relationship between METH-induced hyperthermia, neurotoxicity (striatal DA depletions) and compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b274e3ffc5cfa02706ad7535b86f6a23
https://pubmed.ncbi.nlm.nih.gov/8138969

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Fluoro-gold and pentamidine inhibit the in vitro and in vivo release of dopamine in the striatum of rat

Autor: J F, Bowyer, B, Gough, H W, Broening, G D, Newport, L, Schmued

Publikováno v: The Journal of pharmacology and experimental therapeutics. 266(2)

Fluoro-Gold (FG), first developed as an antifungal/antiparasitic agent, is now also used extensively as a retrograde tracer in histological studies of nervous tissue. The fact that FG is taken up by dopamine (DA) terminals before its retrograde trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02774d110a6282645523fb3fb37a8896
https://pubmed.ncbi.nlm.nih.gov/8355181

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Development of dopamine and N-methyl-D-aspartate systems in rat brain: the effect of prenatal phencyclidine exposure

Autor: S F, Ali, R R, Holson, G D, Newport, W, Slikker, J F, Bowyer

Publikováno v: Brain research. Developmental brain research. 73(1)

Phencyclidine (PCP) inhibits the uptake of the neurotransmitter dopamine (DA), and blocks N-methyl-D-aspartate (NMDA) receptor-regulated ion channels. PCP also binds to sigma receptors in vivo and in vitro in rat brain. Prolonged exposure to PCP in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eeb93029bfeb2747dfad17f58b050233
https://pubmed.ncbi.nlm.nih.gov/7685665

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A further evaluation of the effects of K+ depolarization on glutamate-evoked [3H]dopamine release from striatal slices

Autor: J F, Bowyer, G D, Newport, G W, Lipe, L T, Frame

Publikováno v: The Journal of pharmacology and experimental therapeutics. 261(1)

Exogenous glutamate will evoke dopamine (DA) release from striatal slices in vitro. To further characterize glutamate-evoked DA release from striatal slices, experiments were designed to: 1) determine if sufficient endogenous glutamate can be release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87f60343903600c1ca02e8959da98d30
https://pubmed.ncbi.nlm.nih.gov/1348539

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