Zobrazeno 1 - 10
of 23
pro vyhledávání: '"J. Erik Johnson"'
Publikováno v:
BioTechniques, Vol 43, Iss 4, Pp 517-519 (2007)
Externí odkaz:
https://doaj.org/article/fbf9d3c0608d41b2a27d432ebe4dc026
Autor:
Vidunas Eugene Joseph, Ping Cai, Sujata Kaushikbhai Patel-Brown, Marjolaine Carriere, Zi-rong Zheng, Eun Hee Koh, Hailey Yuan, Michele Weaver, Jason Arnold Lotvin, Antony Mathews, Justin Keith Moran, J. Erik Johnson
Publikováno v:
Journal of Pharmaceutical Sciences. 105:2032-2041
A recombinant Clostridium difficile expression system was used to produce genetically engineered toxoids A and B as immunogens for a prophylactic vaccine against C. difficile– associated disease. Although all known enzymatic activities responsible
Autor:
Farooq Nasar, Ali Javadian, Amara Luckay, John H. Eldridge, Siew Yen Chong, Michael Hendry, Christopher L. Parks, Rashed Abdullah, Timothy J. Zamb, Margaret Lee, Peter B. Little, Susan E. Witko, Narender K. Kalyan, Roger E. Price, Becky Nowak, John W. Coleman, Shakuntala Megati, Stephen A. Udem, J. Erik Johnson, Andrew A. Lackner, Cheryl S. Kotash, Valerie Randolf, David K. Clarke, Michael A. Egan
Publikováno v:
Journal of Virology
In previous work, a prototypic recombinant vesicular stomatitis virus Indiana serotype (rVSIV) vector expressing simian immunodeficiency virus (SIV) gag and human immunodeficiency virus type 1 (HIV-1) env antigens protected nonhuman primates (NHPs) f
Autor:
Julia Li, J. Erik Johnson, Derek John Falconer, Kate West, Kathrin U. Jansen, Oscar Maldonado, Susanne Lang, Jim E. Eyles, Cheryl S. Kotash, Shawn R. Makinen, Phil White, Risini D. Weeratna, James R. Merson, Thomas P. Brown, Paul Wright, George J. Smith, Clare Lees, Susan E. Witko, Paul Cockle, Vidia Roopchand, Peter T. Loudon, Shakuntala Megati, Maninder K. Sidhu
Publikováno v:
Journal of Infectious Diseases. 208:319-329
Background. We evaluated the immunological responses of African green monkeys immunized with multiple F and G protein–based vaccines and assessed protection against the Memphis 37 strain of respiratory syncytial virus (RSV). Methods. Monkeys were i
Autor:
Kathrin U. Jansen, Yahong Peng, Nicholas Kitchin, Joseph Eiden, William C. Gruber, Louise Pedneault, Eric Sheldon, Michael W. Pride, J. Erik Johnson
Publikováno v:
Vaccine. 34(18)
Introduction Clostridium difficile is a significant cause of morbidity and mortality in hospitals, nursing homes, and long-term care facilities. The bacteria can produce 3 toxins, of which the C. difficile toxin A and C. difficile toxin B are the pri
Autor:
R. Michael Hendry, Jennifer Obregon, Narender K. Kalyan, J. Erik Johnson, Kevin J. Wright, Robert J. Natuk, David A. Cooper, David K. Clarke, Priscilla Calderon, Stephen A. Udem, John W. Coleman, Eleanor Ogin-Wilson
Publikováno v:
Vaccine
Recombinant vesicular stomatitis viruses (rVSVs) are being developed as potential HIV-1 vaccine candidates. To characterize the in vivo replication and dissemination of rVSV vectors in mice, high doses of a highly attenuated vector expressing HIV-1 G
Autor:
David K. Clarke, Irene Yurgelonis, J. Erik Johnson, Cheryl S. Kotash, David K. C. Cooper, Farooq Nasar, Min Guo, Margaret Lee, Priscilla Calderon, Robert J. Natuk, R. Michael Hendry, John W. Coleman, Stephen A. Udem, Kevin J. Wright
Publikováno v:
Journal of Virology
Recombinant vesicular stomatitis virus (rVSV) has shown great potential as a new viral vector for vaccination. However, the prototypic rVSV vector described previously was found to be insufficiently attenuated for clinical evaluation when assessed fo
Autor:
Stephen A. Udem, R. Michael Hendry, Patricia A Reilly, Farooq Nasar, J. Erik Johnson, Margaret Lee, Ali Javadian, Roger E. Price, Kenneth Draper, John W. Coleman, David K. Clarke
Publikováno v:
Virology
Although vesicular stomatitis virus (VSV) neurovirulence and pathogenicity in rodents have been well studied, little is known about VSV pathogenicity in non-human primates. To address this question, we measured VSV viremia, shedding, and neurovirulen
Autor:
Stephen A. Udem, Min Guo, J. Erik Johnson, Kevin J. Wright, David K. Clarke, Priscilla Calderon, Farooq Nasar, Margaret Lee, David K. C. Cooper, R. Michael Hendry, Robert J. Natuk
Publikováno v:
Journal of Virology. 81:2056-2064
A variety of rational approaches to attenuate growth and virulence of vesicular stomatitis virus (VSV) have been described previously. These include gene shuffling, truncation of the cytoplasmic tail of the G protein, and generation of noncytopathic
Autor:
J. Erik Johnson, Stephen A. Udem, R. Michael Hendry, Cheryl S. Kotash, Christopher L. Parks, Aaron S. Abramovitz, Krista J. Melville, Sannyu G. Heron, Susan E. Witko, Mohinder S. Sidhu, David K. Clarke, Rebecca M. Nowak, Lee Anne C. Boutilier
Publikováno v:
Journal of Virological Methods. 135:91-101
Recovery of recombinant, negative-strand, nonsegmented RNA viruses from a genomic cDNA clone requires a rescue system that promotes de novo assembly of a functional ribonucleoprotein (RNP) complex in the cell cytoplasm. This is accomplished typically