Blocking Dopamine D2 Receptors by Haloperidol Curtails the Beneficial Impact of Calorie Restriction on the Metabolic Phenotype of High-Fat Diet Induced Obese Mice

Autor: J.P. Schröder-van der Elst, E. T. Parlevliet, H. E. Auvinen, C. P. Coomans, Onno C. Meijer, Hanno Pijl, J. E. de Leeuw van Weenen

Publikováno v: Journal of Neuroendocrinology. 23:158-167

Calorie restriction is the most effective way of expanding life-span and decreasing morbidity. It improves insulin sensitivity and delays the age-related loss of dopamine receptor D(2) (DRD2) expression in the brain. Conversely, high-fat feeding is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b347a6bf9d3aa8c081a9ad00cd4e676
https://doi.org/10.1111/j.1365-2826.2010.02092.x

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility

Autor: Daniel R. Witte, Brenda W.J.H. Penninx, A.G. Uitterlinden, Marian Beekman, Elisabeth M.W. Eekhoff, Louis M. Havekes, Leen M 't Hart, Jeanine J. Houwing-Duistermaat, J.M. Dekker, Gonneke Willemsen, Abbas Dehghan, Johannes A. Romijn, Robert J. Heine, N. van Leeuwen, Bruno Guigas, Nicole Vogelzangs, Torben Hansen, P.E. Slagboom, T.W. van Haeften, J. C. M. Witteman, E. van 't Riet, Hanno Pijl, Oluf Pedersen, Torsten Lauritzen, Niels Grarup, Mark H.H. Kramer, Giel Nijpels, E.J.C. de Geus, Jouke-Jan Hottenga, Albert Hofman, Annemarie M. C. Simonis-Bik, Joris Deelen, Torben Jørgensen, J. E. de Leeuw van Weenen, Michaela Diamant

Publikováno v: Diabetic Medicine, 31(8), 1001-1008. Wiley-Blackwell Publishing Ltd
Diabetic Medicine, 31(8), 1001-1008
Guigas, B, de Leeuw van Weenen, J E, van Leeuwen, N, Simonis-Bik, A M, van Haeften, T W, Nijpels, G, Houwing-Duistermaat, J J, Beekman, M, Deelen, J, Havekes, L M, Penninx, B W J H, Vogelzangs, N, van 't Riet, E, Dehghan, A, Hofman, A, Witteman, J C, Uitterlinden, A G, Grarup, N, Jørgensen, T, Witte, D, Lauritzen, T, Hansen, T, Pedersen, O, Hottenga, J, Romijn, J A, Diamant, M, Kramer, M H H, Heine, R J, Willemsen, G, Dekker, J M, Eekhoff, E M, Pijl, H, de Geus, E J, Slagboom, P E & 't Hart, L M 2014, ' Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility ', Diabetic medicine : a journal of the British Diabetic Association, vol. 31, no. 8, pp. 1001-8 . https://doi.org/10.1111/dme.12464
Guigas, B, de Leeuw van Weenen, J, van Leeuwen, N, Bik-Simonis, A M C, van Haeften, T W, Nijpels, G, Houwing-Duistermaat, J J, Beekman, M, Deelen, J, Havekes, L M, Penninx, B W J H, Vogelzangs, N, van 't Riet, E, Dehghan, A, Hofman, A, Witteman, J C, Uitterlinden, A G, Grarup, N, Jørgensen, T, Witte, D R, Lauritzen, T, Hansen, T, Pedersen, O, Hottenga, J J, Romijn, J A, Diamant, M, Kramer, M H H, Heine, R J, Willemsen, G, Dekker, J M, Eekhoff, E M W, Pijl, H, de Geus, E J C, Slagboom, P E & 't Hart, L M 2014, ' Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility ', Diabetic Medicine, vol. 31, no. 8, pp. 1001-1008 . https://doi.org/10.1111/dme.12464
Diabetic Medicine, 31(8), 1001-1008. Wiley-Blackwell
Guigas, B, van Weenen, J E D, van Leeuwen, N, Simonis-Bik, A M, van Haeften, T W, Nijpels, G, Houwing-Duistermaat, J J, Beekman, M, Deelen, J, Havekes, L M, Penninx, B, Vogelzangs, N, van 't Riet, E, Dehghan, A, Hofman, A, Witteman, J C, Uitterlinden, A G, Grarup, N, Jorgensen, T, Witte, D R, Lauritzen, T, Hansen, T, Pedersen, O, Hottenga, J, Romijn, J A, Diamant, M, Kramer, M H H, Heine, R J, Willemsen, G, Dekker, J M, Eekhoff, E M, Pijl, H, de Geus, E J, Slagboom, P E & t Hart, L M 2014, ' Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility ', Diabetic Medicine, vol. 31, no. 8, pp. 1001-1008 . https://doi.org/10.1111/dme.12464
Diabetic Medicine, 31(8), 1001-1008. Wiley-Blackwell Publishing
Diabetic Medicine, 8, 31, 1001-1008
Diabet Med

Aims Modulation of dopamine receptor D2 (DRD2) activity affects insulin secretion in both rodents and isolated pancreatic beta-cells. We hypothesized that single nucleotide polymorphisms in the DRD2/ANKK1 locus may affect susceptibility to Type 2 dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0dd7308075d7fd9f7f80224db1b2e7
https://pure.eur.nl/en/publications/31068354-33fe-48ca-9856-917bc8f380bd

Pharmacological modulation of dopamine receptor D2-mediated transmission alters the metabolic phenotype of diet induced obese and diet resistant C57Bl6 mice

Autor: Edwin T. Parlevliet, K. Willems van Dijk, Hanno Pijl, J. E. de Leeuw van Weenen, Johannes A. Romijn, S.A.A. van den Berg, J.P. Schröder-van der Elst

Publikováno v: Experimental Diabetes Research
Experimental Diabetes Research, Vol 2011 (2011)

High fat feeding induces a variety of obese and lean phenotypes in inbred rodents. Compared to Diet Resistant (DR) rodents, Diet Induced Obese (DIO) rodents are insulin resistant and have a reduced dopamine receptor D2 (DRD2) mediated tone. We hypoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53121b8248fcc20f87535ec5d44ee2e
https://pubmed.ncbi.nlm.nih.gov/21603181