Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J. E. Villafranca"'
Publikováno v:
Current Opinion in Biotechnology. 7:397-402
In the past year, the three-dimensional structures of two serine/threonine phosphatases, protein phosphatase-1 and protein phosphatase-2b (calcineurin), have been determined. The new information puts previous sequence comparisons and mutagenesis stud
Publikováno v:
Biochemistry. 34:7678-7685
Resonance Raman (RR) spectra are reported for the ternary complex of Escherichia coli thymidylate synthase with the cofactor 5,10-methylenetetrahydrofolate (CH2-H4-folate) and the inhibitor 5-fluoro-2'-deoxyuridylate, excited at 337 or 356 nm, in res
Autor:
T. R. JONES, M. D. VARNEY, S. E. WEBBER, K. K. LEWIS, G. P. MARZONI, C. L. PALMER, V. KATHARDEKAR, K. M. WELSH, S. WEBBER, D. A. MATTHEWS, K. APPELT, W. W. SMITH, C. A. JANSON, J. E. VILLAFRANCA, R. J. BACQUET, E. F. HOWLAND, C. L. J. BOOTH, S. M. HERRMANN, R. W. WARD, J. WHITE, ET AL. ET AL.
Publikováno v:
ChemInform. 27
Autor:
R. Bruce Dunlap, Jerome D. Odom, Ralph J. Cisneros, Mary S. Weir, Jeffrey O. Boles, J. E. Villafranca
Publikováno v:
Biochemistry. 30:11073-11080
Replacement of methionine (Met) residues by selenomethionine (SeMet) was recently shown to facilitate the crystallographic analysis of protein structure through the application of multi-wavelength anomalous diffraction techniques [Yang et al. (1990)
Publikováno v:
Journal of Molecular Biology. 214:937-948
The structure of the Escherichia coli thymidylate synthase (TS) covalent inhibitory ternary complex consisting of enzyme, 5-fluoro-2'-deoxyuridylate (FdUMP) and 5,10-methylene tetrahydrofolate (CH2-H4PteGlu) has been determined at 2.5 A resolution us
Publikováno v:
ICNN
A rule-based and several neural network predictors are developed for identifying disordered regions in proteins. The rule-based predictor, which relied on the observation that disordered regions contain few aromatic amino acids, was suitable only for
Autor:
P, Romero, Z, Obradovic, C R, Kissinger, J E, Villafranca, E, Garner, S, Guilliot, A K, Dunker
Publikováno v:
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing.
Neural network predictors of protein disorder using primary sequence information were developed and applied to the Swiss Protein Database. More than 15,000 proteins were predicted to contain disordered regions of at least 40 consecutive amino acids,
Autor:
A K, Dunker, E, Garner, S, Guilliot, P, Romero, K, Albrecht, J, Hart, Z, Obradovic, C, Kissinger, J E, Villafranca
Publikováno v:
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing.
Observations going back more than 20 years show that regions in proteins with disordered backbones can play roles in their binding to other molecules; typically, the disordered regions become ordered upon complex formation. Thought-experiments with S
Publikováno v:
Protein engineering. 8(7)
The steadily increasing number of high-resolution human immunodeficiency virus (HIV) 1 protease complexes has been the impetus for the elaboration of knowledge-based mean field ligand-protein interaction potentials. These potentials have been linked
Publikováno v:
Biochemistry. 34(23)
Resonance Raman (RR) spectra are reported for the binary complex of Escherichia coli thymidylate synthase (TS) with the substrate analog inhibitor 5-nitrodeoxyuridylate (NDU). The TS/NDU binary complex RR spectrum shows many similarities to the RR sp