Zobrazeno 1 - 9
of 9
pro vyhledávání: '"J. E. Stenger"'
Autor:
J. F. Schwedes, J. E. Stenger, Yun Wang, Mary E. Anderson, Gregory A. Mayr, Michael Reed, P Tegtmeyer, Pin Wang
Publikováno v:
Molecular and Cellular Biology. 14:5182-5191
Wild-type p53 forms tetramers and multiples of tetramers. Friedman et al. (P. N. Friedman, X. B. Chen, J. Bargonetti, and C. Prives, Proc. Natl. Acad. Sci. USA 90:3319-3323, 1993) have reported that human p53 behaves as a larger molecule during gel f
Publikováno v:
Molecular Carcinogenesis. 5:102-106
We have used gradient gel electrophoresis and chemical cross-linking to analyze the quaternary structure of purified, wild-type, murine p53. Under nondenaturing conditions, p53 electrophoreses as tetramers and multiples of tetramers. Under denaturing
Publikováno v:
Scopus-Elsevier
The cofactor ATP stimulates the formation of T-antigen double hexamers on the simian virus 40 core origin of replication (I. A. Mastrangelo, P. V. C. Hough, J. S. Wall, M. Dodson, F. B. Dean, and J. Horwitz, Nature [London] 338:658-662, 1989). We rep
Publikováno v:
AIDS research and human retroviruses. 17(12)
The human immunodeficiency virus type 1 (HIV-1) Tat protein is a key regulatory protein in the HIV-1 replication cycle. Tat interacts with cellular transcriptional factors and cytokines, such as tumor necrosis factor (TNF-alpha), and alters the expre
Autor:
Iris A. Mastrangelo, J. E. Stenger, P. V. C. Hough, Gregory A. Mayr, Yun Wang, P Tegtmeyer, Pin Wang, Michael Reed
Publikováno v:
The EMBO journal. 13(24)
We examined the role of p53 oligomerization in DNA binding and in transactivation. By conventional electron microscopy (EM) and scanning transmission EM, we find that wild-type tetramers contact 18-20 bp at single or tandem 19 bp consensus sequences
Autor:
J. F. Schwedes, Yun Wang, G. Mayr, Pin Wang, J. E. Stenger, P Tegtmeyer, M. E. Anderson, Michael Reed
Publikováno v:
Genesdevelopment. 7(12B)
We have investigated the DNA-binding, oligomerization, and trans-activation functions of isolated segments of murine p53. We find that p53 has two autonomous DNA-binding regions. One domain, from amino acid 280 to 390, forms stable tetramers and bind
Publikováno v:
Genetic Engineering ISBN: 9781461365143
Protein-protein interactions have become a major theme in molecular biology. In many cases, the homo-oligomeric structure of a protein is essential for the activity of that protein. For example, both SV40 large T antigen and the cellular tumor suppre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb02358f7f7fd82666c0732cdc94fd1
https://doi.org/10.1007/978-1-4615-3424-2_3
https://doi.org/10.1007/978-1-4615-3424-2_3
Publikováno v:
Genetic engineering. 14
Publikováno v:
Scopus-Elsevier
Simian virus 40 large T antigen contains a single sequence element with an arrangement of cysteines and histidines that is characteristic of a zinc finger motif. The finger region maps from amino acids 302 through 320 and has the sequence C-302 L K C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a8991e987fd14785c219bf602862cb
https://europepmc.org/articles/PMC240973/
https://europepmc.org/articles/PMC240973/