Výsledky vyhledávání

Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses

Autor: J G Giri, J Wells, S K Dower, C E McCall, R N Guzman, J Slack, T A Bird, K Shanebeck, K H Grabstein, J E Sims

Publikováno v: The Journal of Immunology. 153:5802-5809

Two types of cellular IL-1Rs have been characterized and cloned from both human and murine sources. The type II IL-1R has a very short cytoplasmic domain and does not seem to participate in IL-1 signaling. We demonstrate that type II IL-1Rs are relea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::152e718ee5a733425125233e6b832c4c
https://doi.org/10.4049/jimmunol.153.12.5802

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Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids

Autor: W P Arend, M Malyak, M F Smith, T D Whisenand, J L Slack, J E Sims, J G Giri, S K Dower

Publikováno v: The Journal of Immunology. 153:4766-4774

These studies have examined the binding of the three IL-1 ligands, IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1 ra), to soluble forms of types I and II IL-1Rs (sIL-1RI and sIL-1RII). This interaction was measured in direct binding experi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6e6e7c52d04685bf062e8a49730000c
https://doi.org/10.4049/jimmunol.153.10.4766

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A serine/threonine kinase activity is closely associated with a 65-kDa phosphoprotein specifically recognized by the kappa B enhancer element

Autor: Carol Hopkins Sibley, S K Dower, J E Sims, Kathryn E. Meier, Karol Bomsztyk, Mary A. Valentine, Jerzy Ostrowski

Publikováno v: Journal of Biological Chemistry. 266:12722-12733

The immunoglobulin kappa light chain enhancer, kappa B, is an important cis-acting transcriptional element. kappa B binds a number of proteins including the members of the ubiquitous NF-kappa B family of transcription factors. Agarose beads coupled t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7b2485bb25d8a6b6381eb637c0f04f6
https://doi.org/10.1016/s0021-9258(18)98959-3

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IL-1 signal transduction pathways. I. Two functional IL-1 receptors are expressed in T cells

Autor: E Muñoz, A M Zubiaga, J E Sims, B T Huber

Publikováno v: The Journal of Immunology. 146:136-143

We have recently characterized a subline of the Th2 cell line D10.G4.1, D10A, which responds to exogenous IL-1 in the absence of cofactors. In this cell line IL-1 activates two distinct transmission signal pathways, one leading to increased levels of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89298638831a8a37b569070827a82b72
https://doi.org/10.4049/jimmunol.146.1.136

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CDw121b

Autor: J E, Sims

Publikováno v: Journal of biological regulators and homeostatic agents. 14(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bfe682f0541468dbe68d63dcecbef42a
https://pubmed.ncbi.nlm.nih.gov/10841290

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CD121a

Autor: J E, Sims

Publikováno v: Journal of biological regulators and homeostatic agents. 14(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7cb16546021f9cfbbad352195a7221e8
https://pubmed.ncbi.nlm.nih.gov/10841289

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The cloning and characterization of human MyD88: a member of an IL-1 receptor related family

Autor: T P, Bonnert, K E, Garka, P, Parnet, G, Sonoda, J R, Testa, J E, Sims

Publikováno v: FEBS letters. 402(1)

Murine MyD88, an RNA with homology both to the interleukin-1 receptor signaling domain and to 'death-domains', is rapidly upregulated during differentiation of the myeloleukemic cell line M1. We have cloned the human homologue of murine MyD88 and re-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6db9223aa404c0aa0ef20675c0b1e7a9
https://pubmed.ncbi.nlm.nih.gov/9013863

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Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome

Autor: J H, Pruitt, M B, Welborn, P D, Edwards, T R, Harward, J W, Seeger, T D, Martin, C, Smith, J A, Kenney, R I, Wesdorp, S, Meijer, M A, Cuesta, A, Abouhanze, E M, Copeland, J, Giri, J E, Sims, L L, Moldawer, H S, Oldenburg

Publikováno v: Blood. 87(8)

Plasma interleukin-1 (IL-1) activity is modulated in part through the simultaneous appearance of several inhibitors of IL-1 action, including interleukin-1 receptor antagonist (IL-1ra) and the soluble IL-1 type II receptor (IL-1RII). However, little

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::900dbf3701b2c74ba26ce6738f7b7914
https://pubmed.ncbi.nlm.nih.gov/8605344

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Interleukin-1 receptors

Autor: J E, Sims, S K, Dower

Publikováno v: European cytokine network. 5(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d3dbb69689eadd10aaa51683e74de2e4
https://pubmed.ncbi.nlm.nih.gov/7727687

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Malacoplakia of the prostate sonographically mimicking carcinoma

Autor: D W Horne, S H Parker, A E Chantelois, J E Sims

Publikováno v: Radiology. 177(1)

Malacoplakia is an uncommon granulomatous inflammatory disorder that usually affects the urinary bladder and only rarely affects the prostate. Prostatic malacoplakia was detected in five patients by means of transrectal sonography and confirmed by me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212fb6d86b7dc8928aea10f2183c2b2d
https://pubmed.ncbi.nlm.nih.gov/2204965

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