Early Access for Medicines in ITALY: The Case of Ruxolitinib for Patients with Graft-Versus-Host Disease.

Autor: Gozzo, Lucia¹ (AUTHOR) luciagozzo86@icloud.com, Leotta, Salvatore² (AUTHOR) leotta3@yahoo.it, Romano, Giovanni Luca³ (AUTHOR) giovannienrico.lombardo@unikore.it, Vetro, Calogero² (AUTHOR) gerovetro@gmail.com, Duminuco, Andrea² (AUTHOR) andrea.duminuco@gmail.com, Milone, Giuseppe² (AUTHOR) giuseppe.milone@gmail.com, Cupri, Alessandra² (AUTHOR) alessandracupri@hotmail.it, Palumbo, Fanny Erika² (AUTHOR) fannypalumbo@gmail.com, Brancati, Serena¹ (AUTHOR) rosyruscica@gmail.com, Ruscica, Rosy¹ (AUTHOR) longolaura@hotmail.com, Longo, Laura¹ (AUTHOR) danielac.vitale@gmail.com, Vitale, Daniela Cristina¹ (AUTHOR) f.drago@unict.it, Fiorenza, Giorgia⁴ (AUTHOR) giorgia.f1d@gmail.com, Lombardo, Giovanni Enrico³ (AUTHOR), Lazzara, Antonio⁵ (AUTHOR) antonio.lazzara@gmail.com, Di Raimondo, Francesco² (AUTHOR) diraimon@unict.it, Palumbo, Giuseppe Alberto² (AUTHOR) palumbo.giuseppealberto@gmail.com, Drago, Filippo^1,4,6 (AUTHOR)

Publikováno v: Journal of Clinical Medicine. Jul2024, Vol. 13 Issue 14, p4273. 9p.

A guanylyl cyclase from Paramecium with 22 transmembrane spans. Expression of the catalytic domains and formation of chimeras with the catalytic domains of mammalian adenylyl cyclases

Autor: J U, Linder, T, Hoffmann, U, Kurz, J E, Schultz

Publikováno v: The Journal of biological chemistry. 275(15)

Paramecium has a 280-kDa guanylyl cyclase. The N terminus resembles a P-type ATPase, and the C terminus is a guanylyl cyclase with the membrane topology of canonical mammalian adenylyl cyclases, yet with the cytosolic loops, C1 and C2, inverted compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e71df0ab71325443a5c1b57d55d63be7
https://pubmed.ncbi.nlm.nih.gov/10753932

Expression pattern of aquaporin water channels in the inner ear of the rat. The molecular basis for a water regulation system in the endolymphatic sac

Autor: E, Beitz, H, Kumagami, P, Krippeit-Drews, J P, Ruppersberg, J E, Schultz

Publikováno v: Hearing research. 132(1-2)

Mammalian aquaporins constitute a family of so far 10 related water channel proteins which mediate osmotically driven water fluxes across the plasma membrane. Because regulation of the ionic composition and osmolality of inner ear fluids is of great

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5c22e15670dc50b137b8f723aa516fae
https://pubmed.ncbi.nlm.nih.gov/10392550

The mammalian aquaporin water channel family: A promising new drug target

Autor: E, Beitz, J E, Schultz

Publikováno v: Current medicinal chemistry. 6(6)

In mammalian cells water slowly passes across cell membranes driven by osmotic forces. However, the speed of this process is insufficient for sustained and rapid water fluxes required for an active regulation of water homeostasis, e.g. in the kidney

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7163605f82d9eee6e9de0a9ae0874ef3
https://pubmed.ncbi.nlm.nih.gov/10213793

Glibenclamide-induced blockade of ischemic preconditioning is time dependent in intact rat heart

Autor: Garrett J. Gross, J. E. Schultz, Zhenhai Yao, I. Cavero

Publikováno v: The American journal of physiology. 272(6 Pt 2)

The ATP-sensitive potassium (KATP) channel has been demonstrated to be a potential mediator of ischemic preconditioning (PC) in most species, with the exception of the rat. This conclusion is based on the failure of the KATP channel antagonist gliben

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1063356cc158b113ea5f3f4bbe0489a7
https://pubmed.ncbi.nlm.nih.gov/9227537