Výsledky vyhledávání - "J. E. Sadler"

Multi‐step binding of ADAMTS‐13 to von Willebrand factor

Autor: Patricia J. Anderson, J E Sadler, Hendrik B. Feys, Karen Vanhoorelbeke, Elaine M. Majerus

Publikováno v: Journal of Thrombosis and Haemostasis. 7:2088-2095

Summary. Background: ADAMTS-13 proteolytic activity is controlled by the conformation of its substrate, von Willebrand factor (VWF), and changes in the secondary structure of VWF are essential for efficient cleavage. Substrate recognition is mediated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eaf70ed501bace81c5715a561ab512
https://doi.org/10.1111/j.1538-7836.2009.03620.x

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von Willebrand factor assembly and secretion

Autor: J E Sadler

Publikováno v: Journal of Thrombosis and Haemostasis. 7:24-27

During its life history, von Willebrand factor (VWF) experiences a remarkable sequence of conformational changes that are triggered by differences in pH between the endoplasmic reticulum (ER), Golgi and extracellular environments. VWF subunits dimeri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579c53b983ef9fb7f5bf513a4f8211a1
https://doi.org/10.1111/j.1538-7836.2009.03375.x

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Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor

Publikováno v: Journal of Thrombosis and Haemostasis. 4:2103-2114

von Willebrand disease (VWD) is reportedly the most common bleeding disorder and is caused by deficiencies and/or defects in the adhesive plasma protein von Willebrand factor (VWF). Functionally, normal VWF prevents bleeding by promoting both primary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5891803e5da91c825bd131b286b8f4d
https://doi.org/10.1111/j.1538-7836.2006.02146.x

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Characterization of the Residues Involved in the Human α-Thrombin−Haemadin Complex: An Exosite II-Binding Inhibitor

Autor: John Richardson, Pablo Fuentes-Prior, Robert Huber, Wolfram Bode, J E Sadler

Publikováno v: Biochemistry. 41:2535-2542

Haemadin is a 57-amino acid thrombin inhibitor from the land-living leech Haemadipsa sylvestris, whose structure has recently been determined in complex with human alpha-thrombin. Here we communicate the effect of ionic strength on the kinetics of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5029c66aef89a58f87a8a4344d34fa5
https://doi.org/10.1021/bi011605q

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Report on the workshop: Von Willebrand factor and thrombotic thrombocytopenic purpura

Autor: J E Sadler, P Ganguly, Joel L. Moake, P. M. Mannucci

Publikováno v: American Journal of Hematology. 68:122-126

INTRODUCTION (Dr. P. Ganguly)A workshop on von Willebrand factor (vWf) andThrombotic Thrombocytopenic Purpura (TTP) was orga-nized by the Division of Blood Diseases and Resourcesof the National Heart, Lung, and Blood Institute(NHLBI) and was held on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9dda35395d31f07afde67dd8d7ac6c46
https://doi.org/10.1002/ajh.1163

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Structure of the Ser195Ala mutant of human α-thrombin complexed with fibrinopeptide A(7–16): evidence for residual catalytic activity

Autor: Alexander Tulinsky, Raman Krishnan, J E Sadler

Publikováno v: Acta Crystallographica Section D Biological Crystallography. 56:406-410

The Ser195Ala mutant of human alpha-thrombin was complexed with fibrinopeptide A(7-22) (FPA) in an effort to describe the (P1'-P6') post-cleavage binding subsites of the fibrinogen-recognition exosite and define more clearly the nature of the Michael

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2950b620b4c25d8b223f56b3b6c1950c
https://doi.org/10.1107/s0907444900001487

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Acquired von Willebrand Syndrome: Data from an International Registry

Autor: U. Budde, Francesco Rodeghiero, Paolo Bucciarelli, Hiroshi Mohri, Jacob H. Rand, P. J. J. Van Genderen, Augusto B. Federici, J E Sadler, Dominique Meyer

Publikováno v: Thrombosis and Haemostasis. 84:345-349

SummaryThe acquired von Willebrand syndrome (AvWS) is a rare bleeding disorder with laboratory findings similar to those of congenital von Willebrand disease (vWD). Despite the numerous cases reported in the literature until 1999 (n = 266), large stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efe11dd89a73fcf70ddd824d7c7204cc
https://doi.org/10.1055/s-0037-1614018

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Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide 1 1Edited by R. Huber

Autor: Xinglong Zheng, Sergey Korolev, Deshun Lu, J E Sadler, Gabriel Waksman, Klaus Fütterer, Kai Tan

Publikováno v: Journal of Molecular Biology. 292:361-373

Enteropeptidase is a membrane-bound serine protease that initiates the activation of pancreatic hydrolases by cleaving and activating trypsinogen. The enzyme is remarkably specific and cleaves after lysine residues of peptidyl substrates that resembl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e783b108607a1efeb868eb95cc122f0d
https://doi.org/10.1006/jmbi.1999.3089

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