Zobrazeno 1 - 10
of 267
pro vyhledávání: '"J. E. Reardon"'
Publikováno v:
Plant Disease. 89:228-236
Most fungicide sprays applied to apple orchards in the New England states are targeted at the management of apple scab. Researchers have developed action thresholds that aid in decision-making on whether early spring fungicide applications could be e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f7cbb1c45306fa6fd2d6b1c3c3319d
https://doi.org/10.1094/pd-89-0228
https://doi.org/10.1094/pd-89-0228
Autor:
Phillip A. Furman, Jeanne E. Wilson, Ann Aulabaugh, J E Reardon, Casey D. Morrow, Brent Caligan, Sandra A. Jablonski, Sylvia A. McPherson, John K. Wakefield
Publikováno v:
Journal of Biological Chemistry. 271:13656-13662
Mutations were made in recombinant human immunodeficiency virus type-1 reverse transcriptase (RT) by substituting methionine 184 with alanine (M184A) or valine (M184V), and steady-state and pre-steady-state kinetic constants were determined. The Km v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::536ebeb195336aa928a00b632c70f50d
https://doi.org/10.1074/jbc.271.23.13656
https://doi.org/10.1074/jbc.271.23.13656
Publikováno v:
Antiviral Chemistry and Chemotherapy. 6:345-355
This review concerns the effect of stereoisomerism on the selective activity of anti-HIV and anti-HBV nucleoside analogues.The synthesis of a number of nucleoside analogues with anti-HIV and anti-HBV activity yields mixtures of 1-β-D and 1-β-L ster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e31d49c057b75a9e69a60df5b93a1bab
https://doi.org/10.1177/095632029500600601
https://doi.org/10.1177/095632029500600601
Publikováno v:
Journal of Biological Chemistry. 270:15827-15831
Valaciclovir is an oral prodrug of the antiherpetic agent acyclovir. An enzyme that hydrolyzes valaciclovir to acyclovir, valaciclovir hydrolase (VACVase), was purified from rat liver and characterized. VACVase was a basic (pI 9.4) protein associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ac0398d78174a92d1b669437dc0978
https://doi.org/10.1074/jbc.270.26.15827
https://doi.org/10.1074/jbc.270.26.15827
Autor:
M H St Clair, G B Roberts, Susan Mary Daluge, D. J. M. Purifoy, I K Dev, Paul Savina, J E Reardon, K M Ayers, N R Parry, P Novak
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:1590-1603
5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83) is a selective anti-human immunodeficiency virus (HIV) agent. When tested in phytohemagglutinin-stimulated normal human peripheral blood lymphocytes against fresh clinical isolates of HIV type 1 (HIV-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e84be57ccdbf68fe18df0905bfba93f
https://doi.org/10.1128/aac.38.7.1590
https://doi.org/10.1128/aac.38.7.1590
Publikováno v:
Journal of Biological Chemistry. 269:15999-16008
3'-Azido-3'-deoxythymidine (AZT), AZT 5'-monophosphate, and AZT 5'-triphosphate (AZTTP) were reduced by dithiothreitol with second-order rate constants of 2.30 x 10(-3), 1.50 x 10(-3), and 7.46 x 10(-4) M-1 s-1, respectively. Handlon and Oppenheimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a4f6e773faf103e8ef7982706d1e682
https://doi.org/10.1016/s0021-9258(17)33964-9
https://doi.org/10.1016/s0021-9258(17)33964-9
Autor:
J E Reardon
Publikováno v:
Journal of Biological Chemistry. 268:8743-8751
A minimal kinetic mechanism for HIV reverse transcriptase (RT)-catalyzed RNA-dependent and DNA-dependent DNA polymerization was determined by pre-steady-state kinetic methods to be: [formula: see text] where E, TP, dNTP, and PPi are RT, template-prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e55620c40381fcec44d6bb5ec8819e0
https://doi.org/10.1016/s0021-9258(18)52937-9
https://doi.org/10.1016/s0021-9258(18)52937-9
Publikováno v:
ChemInform. 24
3'-Azido-3'-deoxythymidine-5'-phosphonate was synthesized by a five-step reaction sequence. The 5'-phosphonate was inactive against HIV-1 in MT4 cells. The absence of activity against HIV-1 was at least partially explained by demonstrating that the K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c04a713892891f91610153fa2a43b013
https://doi.org/10.1002/chin.199301273
https://doi.org/10.1002/chin.199301273
Publikováno v:
Journal of Biological Chemistry. 267:25019-25024
beta-L-3'-Deoxythymidine 5'-triphosphate (L-ddTTP) and beta-L-3'-deoxy-2',3'-didehydrothymidine 5'-triphosphate (L-d4TTP) were substrates for human immunodeficiency virus reverse transcriptase, Escherichia coli DNA polymerase I (Klenow), and Sequenas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f25e936918b93c31008a6d6e647db81c
https://doi.org/10.1016/s0021-9258(19)73999-4
https://doi.org/10.1016/s0021-9258(19)73999-4
Autor:
J E Reardon, Susan Mary Daluge, Sam Hopkins, Richard L. Miller, Edward P. Garvey, Boyd Frank Leslie, Wayne H. Miller
Publikováno v:
Journal of Biological Chemistry. 267:21220-21224
Two enantiomers of carbovir, a carbocyclic analog of 2',3'-dideoxyguanosine, were compared with respect to their phosphorylation and the phosphorylation of their nucleotides by mammalian enzymes. 5'-Nucleotidase catalyzed the phosphorylation of (-)-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3649cfa2c09c75b8bbfd7146aea55db3
https://doi.org/10.1016/s0021-9258(19)36820-6
https://doi.org/10.1016/s0021-9258(19)36820-6