Zobrazeno 1 - 4
of 4
pro vyhledávání: '"J. E. Manning Fox"'
Autor:
A Clark, Austin Bautista, Nicola L. Beer, Anne Raimondo, Amy Barrett, M Umapathysivam, J. E. Manning Fox, Anna L. Gloyn, P Rorsman, Christopher J. Groves, B Hastoy, Patrick E. MacDonald, Dai X-Q., Soren K. Thomsen
Molecular mechanisms underpinning the genetic risk for type 2 diabetes (T2D) remain poorly understood, hindering translation into new therapies. Recently, genome-wide studies identified two coding variants inPeptidylglycine Alpha-amidating Monooxygen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c57e350a9913128a8f2ce5ad4e66ae
Autor:
Patrick E. MacDonald, Jelena Kolic, Tatsuya Kin, J. E. Manning Fox, Aliya F. Spigelman, Catherine Hajmrle, A. M. J. Shapiro, E. Leung, Gregory Plummer
Publikováno v:
Diabetologia. 56:1339-1349
Phosphatidylinositol 3-OH kinases (PI3Ks) regulate beta cell mass, gene transcription, and function, although the contribution of the specific isoforms is unknown. As reduced type 1A PI3K signalling is thought to contribute to impaired insulin secret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3b483c5b6cc1a120a27929038f93a4
https://doi.org/10.1007/s00125-013-2882-4
https://doi.org/10.1007/s00125-013-2882-4
Autor:
Herbert Y. Gaisano, Youhou Kang, Marina Casimir, Xiao Qing Dai, Aliya F. Spigelman, A. M. J. Shapiro, Patrick E. MacDonald, Dafna Singer-Lahat, Tatsuya Kin, Ilana Lotan, J. E. Manning Fox, Dodo Chikvashvili, Catherine Hajmrle, Gregory Plummer
Publikováno v:
Diabetologia. 55(6)
It is thought that the voltage-dependent potassium channel subunit Kv2.1 (Kv2.1) regulates insulin secretion by controlling beta cell electrical excitability. However, this role of Kv2.1 in human insulin secretion has been questioned. Interestingly,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def38d158cd71db887750363830e80ab
https://pubmed.ncbi.nlm.nih.gov/22411134
https://pubmed.ncbi.nlm.nih.gov/22411134
Autor:
Jamie W. Joseph, Michael B. Wheeler, Armen V. Gyulkhandanyan, Catherine B. Chan, J D MacLellan, J E Manning-Fox, Monique C. Saleh, Timothy S. McQuaid
Publikováno v:
The Journal of endocrinology. 190(3)
We investigated whether an increase in cAMP could normalize glucose-stimulated insulin secretion (GSIS) in uncoupling protein-2 (UCP2) overexpressing (ucp2-OE) β-cells. Indices of β-cell (β-TC-6f7 cells and rodent islets) function were measured af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88aabaa6b787be31fb9636e2afbdecf4
https://pubmed.ncbi.nlm.nih.gov/17003268
https://pubmed.ncbi.nlm.nih.gov/17003268