Optimization of large animal MI models : A systematic analysis of control groups from preclinical studies

Autor: P. P. Zwetsloot, L. H. J. A. Kouwenberg, E. S. Sena, J. E. Eding, H. M. den Ruijter, J. P. G. Sluijter, G. Pasterkamp, P. A. Doevendans, I. E. Hoefer, S. A. J. Chamuleau, G. P. J. van Hout, S. J. Jansen of Lorkeers

Publikováno v: Scientific Reports, 7(1). Nature Publishing Group
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Zwetsloot, P P, Kouwenberg, L H J A, Sena, E S, Eding, J E, Den Ruijter, H M, Sluijter, J P G, Pasterkamp, G, Doevendans, P A, Hoefer, I E, Chamuleau, S A J, Van Hout, G P J & Jansen Of Lorkeers, S J 2017, ' Optimization of large animal MI models; a systematic analysis of control groups from preclinical studies ', Scientific Reports, vol. 7, no. 1 . https://doi.org/10.1038/s41598-017-14294-z
Scientific Reports

Large animal models are essential for the development of novel therapeutics for myocardial infarction. To optimize translation, we need to assess the effect of experimental design on disease outcome and model experimental design to resemble the clini

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https://dspace.library.uu.nl/handle/1874/356640