Zobrazeno 1 - 10 of 13 pro vyhledávání: '"J. E. Doe"'
1
A proposal to improve clarity and communication in the EU Classification process for chemicals for carcinogenicity and reproductive and developmental toxicity
Autor: J. E. Doe
Publikováno v: Journal of Applied Toxicology
There is an issue in the EU classification of substances for carcinogenicity and for reproductive or developmental toxicity which has brought difficulties to those involved in the process. The issue lies in the inability of the classification system
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db02a2d10fc3d03e72bea9c0af8b004
https://doi.org/10.1002/jat.3045
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2
Prenatal Toxicity of Inhaled Polymeric Methylenediphenyl Diisocyanate (MDI) Aerosols in Pregnant Wistar Rats
Autor: R. W. Tyl, J. Hellwig, A. O. Gamer, J. E. Doe
Publikováno v: Toxicological Sciences. 54:431-440
Mated Wistar rats, 25/group, were exposed to polymeric methylenediphenyl diisocyanate (MDI) aerosol of respirable size for 6 h/day, on gestational days (gd) 6 through 15, at 0, 1, 4, and 12 mg/m3. Maternal clinical signs, body weights, and feed and w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20478ceab7c65da155d6962250f86a21
https://doi.org/10.1093/toxsci/54.2.431
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3
Respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate in guinea pigs: comparison with trimellitic anhydride
Autor: R. Dearman, Timothy D. Landry, J. E. Doe, Paul M. Hext, Jürgen Pauluhn
Publikováno v: Inhalation toxicology. 11(3)
Published evidence demonstrates successful induction and elicitation of respiratory hypersensitivity in guinea pigs by the known human respiratory allergens trimellitic anhydride (TMA) and diphenylmethane-4,4'-diisocyanate (MDI). From these data it i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d503b1e2faf3270a4c757cb2bb8b108
https://pubmed.ncbi.nlm.nih.gov/10380166
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5
Comparative aspects of the reproductive toxicology by inhalation in rats of ethylene glycol monomethyl ether and propylene glycol monomethyl ether
Autor: D.J. Tinston, D. M. Samuels, G. A. de S. Wickramaratne, J. E. Doe
Publikováno v: Toxicology and Applied Pharmacology. 69:43-47
This study was designed to provide a rapid assessment of the effect of two glycol ethers on some aspects of reproduction in the rat. Exposure was by inhalation at 100 and 300 ppm (EGME) and 200 and 600 ppm (PGME) for 6 hr/day. The study was in two pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68332b202f03a2b6edf4370f680fa8e2
https://doi.org/10.1016/0041-008x(83)90117-5
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6
Assessment of the reproductive toxicology of bromochlorodifluoromethane (BCF, halon 1211) in the rat
Autor: G A Wickramaratne, J E Doe, D L Kinsey, D J Tinston
Publikováno v: Occupational and Environmental Medicine. 45:755-760
The effect of bromochlorodifluoromethane (BCF) on reproduction in the rat has been investigated in two studies. Pregnant female rats were exposed by inhalation to 1000, 10,000, or 50,000 ppm BCF for six hours a day on days six to 15 of gestation (day
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::145dbed0fd7be60722e9101fc5370a5c
https://doi.org/10.1136/oem.45.11.755
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7
Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies
Autor: J E Doe
Publikováno v: Environmental Health Perspectives
An inhalation teratology study was conducted in rats at 10, 50 and 250 ppm ethylene glycol monoethyl ether (EGEE) and in rabbits at 10, 50 and 175 ppm EGEE. This study was designed to supplement a study conducted for NIOSH which showed teratogenic ef
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123d2a0fff182b038bbfa1d410847e42
http://europepmc.org/articles/PMC1568288
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8
Inhalation hazard test. Interlaboratory trial with OECD method 403
Autor: J. E. Doe, H. J. Klimisch, Jürgen Pauluhn, D. G. Clark, H. W. Hollander, G. W. Cambridge
Publikováno v: Archives of toxicology. 61(4)
Six industrial laboratories validated the Inhalation Hazard Test (OECD Method 403) using eight volatile chemicals. The test gave similar results in all laboratories, despite variation in inhalation exposure systems and strain of rat used. Detailed at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f47ebcfec84e18b26c078fc01f223d
https://pubmed.ncbi.nlm.nih.gov/3377686
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9
Further studies on the toxicology of the glycol ethers with emphasis on rapid screening and hazard assessment
Autor: J E Doe
Publikováno v: Environmental Health Perspectives
The discovery that ethylene glycol monomethyl ether (EGME) could affect the testis and the developing fetus in laboratory animals prompted further work to understand the effect of EGME and to examine additional glycol ethers to see if they showed EGM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a1113b3db7980a9cd42d3f34a24f45
https://pubmed.ncbi.nlm.nih.gov/6499805
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10
The effects on the rat testis of single inhalation exposures to ethylene glycol monoalkyl ethers, in particular ethylene glycol monomethyl ether
Autor: D M, Samuels, J E, Doe, D J, Tinston
Publikováno v: Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement. 7
The effects of a single inhalation exposure to the rat of the saturated vapours derived from four ethylene glycol monoalkyl ethers have been investigated. No effects on the testis were observed following exposure to ethylene glycol isopropyl ether (E
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae2d85a6d4aa4cc66fffa592ec5899e3
https://pubmed.ncbi.nlm.nih.gov/6595980
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