Zobrazeno 1 - 10
of 137
pro vyhledávání: '"J. E. Coligan"'
Autor:
M Vergelli, B Hemmer, M Kalbus, A B Vogt, N Ling, P Conlon, J E Coligan, H McFarland, R Martin
Publikováno v:
The Journal of Immunology. 158:3746-3752
In this report, we demonstrate for autoreactive T cell clones that single amino acid modifications of the antigenic ligand can result in not only abrogated, decreased, or unmodified, but also increased, T cell responsiveness (superagonist ligands). W
Autor:
Marianne L. Egan, Susan K. Hollingshead, W. Winn Chatham, Jan Novak, J. E. Coligan, W F Averett, David G. Pritchard, Bo Lin
Publikováno v:
Infection and Immunity. 64:3401-3406
Group B streptococci were recently reported to possess a cell-associated collagenase. Although the enzyme hydrolyzed the synthetic collagen-like substrate N-(3-[2-furyl]acryloyl)-Leu-Gly-Pro-Ala, we found that neither the highly purified enzyme nor c
Publikováno v:
The Journal of Immunology. 156:4672-4679
We purified a DNA binding protein that recognizes a portion of the MHC class I regulatory element region 1/NF-kappaB binding site whose expression correlates with the expression of a MHC class I transgene in the thymus. The N-terminal amino acid sequ
Autor:
M J Halvorson, J E Coligan
Publikováno v:
The Journal of Immunology. 155:4567-4574
A class of adhesion molecules, the VLA integrins, are expressed on thymocytes and have been shown to affect immature thymocyte differentiation in vitro. This study examines the ability of cAMP to regulate VLA receptor function in thymocytes. Pharmaco
Publikováno v:
The Journal of Immunology. 154:2125-2133
Beta 1 integrins are a family of alpha beta heterodimers that serve as cell surface receptors for extracellular matrix proteins. We demonstrate that the anti-mouse integrin beta 1 chain mAb KMI6 selectively recognizes a beta 1 epitope that is constit
Publikováno v:
The Journal of Immunology. 154:500-510
Integrins comprise a superfamily of alpha beta heterodimers that serve as cell signaling as well as adhesion molecules. We demonstrate that the alpha 3 beta 1 and alpha 6 beta 1 integrins are laminin/merosin receptors expressed in human thymocytes. B
Autor:
Susan K. Hollingshead, David G. Pritchard, J. E. Coligan, Marianne L. Egan, John Baker, Bo Lin
Publikováno v:
Journal of Biological Chemistry. 269:30113-30116
Group B streptococci (GBS) are a major cause of serious human perinatal infections. Most clinical isolates of GBS secrete hyaluronate lyase, and production of high levels of the enzyme has been associated with strain virulence. Degenerate oligonucleo
Publikováno v:
The Journal of Immunology. 153:1665-1673
Antigenic peptides are presented to CD4+ T cells by MHC class II molecules via a highly polymorphic peptide-binding groove. The two HLA-DR alleles isotypically expressed on HLA-DR15Dw2-positive cells, DRB1*1501 (DR2b) and DRB5*0101 (DR2a) molecules,
Publikováno v:
The Journal of Immunology. 152:2270-2278
IFNs are well characterized macrophage-activating agents. Their varied effects are largely mediated via the induction of many genes, whose products act in concert to induce macrophage differentiation. Homologous DNA sequences have been found upstream
Publikováno v:
The Journal of Immunology. 151:1789-1801
Merosin is a 700 kDa multichain protein that has several properties in common with laminin, one of the major extracellular matrix proteins present in basement membranes. Both contain B1 and B2 light chains, but merosin has a distinct M-chain compared