Zobrazeno 1 - 10
of 254
pro vyhledávání: '"J. E. Balow"'
Publikováno v:
The Journal of Immunology. 155:1809-1817
Glucocorticoid hormones (GC) have profound effects on the development and homeostasis of the immune system. In this communication we present evidence that GC regulate Ca(2+)-mediated pathways of T cell activation by a mechanism that involves abrogati
Publikováno v:
The Journal of Immunology. 152:3137-3151
Anti-DNA IgA autoantibodies play an important immunopathologic role in SLE patients. To analyze the cellular origin and the VH and VL structure of anti-DNA IgA autoantibodies, we generated five IgA1 mAbs to DNA using B lymphocytes from three SLE pati
Publikováno v:
The Journal of Immunology. 151:4081-4089
Interaction of IL-2 with its high affinity membrane receptor complex (IL-2R) present on activated T lymphocytes induces cell proliferation and mediates effector functions. Glucocorticoids inhibit IL-2 production by inhibiting TCR-mediated signal tran
Publikováno v:
The Journal of Immunology. 150:3109-3118
Transforming growth factors-beta (TGF-beta) modulate immune responses by inhibiting the proliferation of normal T lymphocytes. To examine the mechanism(s) of this inhibition, we studied the effect of TGF-beta 1 on selected events associated with the
Autor:
G Thyphronitis, T Kinoshita, K Inoue, J E Schweinle, G C Tsokos, E S Metcalf, F D Finkelman, J E Balow
Publikováno v:
The Journal of Immunology. 147:224-230
A mAb, 7G6, that binds to mouse CR1 and CR2 and down-modulates their expression on splenic B cells in vivo, was used to determine whether a decrease in CR1 and CR2 expression affects antibody responses to different T-dependent and T-independent Ag. I
Publikováno v:
The Journal of Immunology. 145:2701-2705
With the use of nuclear transcription run-off assays we have determined the kinetics of transcriptional activity for the c-fos, c-myc, DR beta, DQ beta, (TfR), Blast-1, and Ig kappa genes in human tonsillar B lymphocytes of high to intermediate densi
Autor:
J. Tisdale, Sharda G. Sabnis, J. Barrett, N. Geller, Andreas Lundqvist, T. Igarashi, J. E. Balow, Ramaprasad Srinivasan, Y. Takahashi, H. Austin, R. Childs
Publikováno v:
British journal of haematology. 131(1)
Summary Nephrotic syndrome (NS) is an extremely rare complication of myeloablative allogeneic haematopoietic cell transplantation (HCT) that usually occurs in association with chronic graft-versus-host disease (C-GVHD). We observed an unexpectedly hi
Autor:
H A, Austin, J E, Balow
Publikováno v:
Seminars in nephrology. 20(3)
Patients with lupus nephritis pose a therapeutic challenge and stimulate investigation of innovative treatment strategies. Although patient survival and renal function outcomes have improved over the last 4 decades, contemporary immunosuppressive reg
Publikováno v:
Seminars in nephrology. 20(1)
Systemic lupus erythematosus (SLE) is envisioned to arise from hyperactivate helper T-cells that cause polyclonal B-cell secretion of pathogenic autoantibodies and formation of immune complexes which deposit in sites such as the kidney. The most wide
Autor:
D T, Boumpas, I O, Tassiulas, T A, Fleisher, E, Vaughan, S, Piscitelli, Y, Kim, F, Pucino, J E, Balow, H A, Austin
Publikováno v:
Clinical nephrology. 52(2)
Lymphocytes are believed to play a role in the induction and perpetuation of membranous nephropathy. Fludarabine is a purine nucleoside analog with selective activity against both dividing and resting lymphocytes. We evaluated the tolerance, toxicity