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Akademický článek

Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model

Autor: Alexis R. Steinmetz, Morgan Pierce, Alberto Martini, Come Tholomier, Ganiraju Manyam, Yan Chen, Akshay Sood, Jonathan J. Duplisea, Burles A. Johnson, Bogdan A. Czerniak, Byron H. Lee, Chinnaswamy Jagannath, Seppo Yla-Herttuala, Nigel R. Parker, David J. McConkey, Colin P. Dinney, Sharada Mokkapati

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionNadofaragene firadenovec (Ad-IFNα/Syn3) is now approved for BCG-unresponsive bladder cancer (BLCA). IFNα is a pleiotropic cytokine that causes direct tumor cell killing via TRAIL-mediated apoptosis, angiogenesis inhibition, and activati

Externí odkaz: https://doaj.org/article/63a622d2fe494a5898ec7dc003c1d01b

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Akademický článek

Lentiviral interferon: A novel method for gene therapy in bladder cancer

Publikováno v: Molecular Therapy: Oncolytics, Vol 26, Iss , Pp 141-157 (2022)

Interferon alpha (IFNα) gene therapy is emerging as a new treatment option for patients with non-muscle invasive bladder cancer (NMIBC). Adenoviral vectors expressing IFNα have shown clinical efficacy treating bacillus Calmette-Guerin (BCG)-unrespo

Externí odkaz: https://doaj.org/article/5de742af926648bcab7840c44c6fac3e

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Akademický článek

Characteristics associated with disease prevalence, SCORTEN, length of stay, and mortality in hospitalized SJS/TEN patients: A single-center, eleven-year experience

Autor: Michael J. Duplisea, Carolyn M. Ziemer, Sarah L. Laughon, Felicia N. Williams

Publikováno v: Burns Open, Vol 6, Iss 3, Pp 110-115 (2022)

Stevens-Johnson syndrome (SJS), toxic-epidermal necrolysis (TEN), and SJS-TEN overlap syndrome form a continuum of rare, life-threatening disease that often warrants immediate and intensive treatment in a burn center. Our objective in this study was

Externí odkaz: https://doaj.org/article/595a41f37a444a40bb1228be9beb90e3

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The development of interferon-based gene therapy for BCG unresponsive bladder cancer: from bench to bedside

Autor: Kimberly S. Schluns, Nigel Parker, Seppo Ylä-Herttuala, Devin Plote, Colin P.N. Dinney, David J. McConkey, Jonathan J. Duplisea, Sharada Mokkapati

Publikováno v: World J Urol

BCG unresponsive bladder cancer is an inherently resistant disease state for which the preferred treatment is radical cystectomy. To date, no effective intravesical therapies exist for patients who possess these resistant tumors. For this reason, man

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2456970e0fe132a135f0eff681057c9
https://doi.org/10.1007/s00345-018-2553-7

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Should chemotherapy still be used to treat all muscle invasive bladder cancer in the 'era of immunotherapy'?

Autor: Jonathan J. Duplisea, Colin P.N. Dinney

Publikováno v: Expert Review of Anticancer Therapy. 19:543-545

Platinum-based chemotherapy has served as the mainstay systemic treatment for muscle invasive bladder cancer (MIBC) for decades. Its use in the neoadjuvant (NAC), adjuvant (AC), and salvage setting...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4764adb83d8f9dc666dffe46d5006a78
https://doi.org/10.1080/14737140.2019.1625773

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Akademický článek

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OUTCOMES OF NON-METASTATIC MICROPAPILLARY VARIANT UPPER TRACT UROTHELIAL CARCINOMA

Autor: Bogdan Czerniak, John C. Araujo, Charles C. Guo, Jonathan J. Duplisea, Arlene O. Siefker-Radtke, Surena F. Matin, Colin P.N. Dinney, Firas G. Petros, Roger Li, Bryan Fellman

Publikováno v: Urol Oncol

Purpose Micropapillary variant upper tract urothelial cancer (MP-UTUC) is a rare malignancy with little known regarding its clinical course and/or optimal treatment. In this case series, we describe patient characteristics, surgical treatment, oncolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d4e365e5c6007d4e12b2ed285b4bde
https://europepmc.org/articles/PMC6511295/

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Trends and disparities in the use of neoadjuvant chemotherapy for muscle-invasive urothelial carcinoma

Autor: Stephen A. Boorjian, Roger Li, Ross J. Mason, Colin P.N. Dinney, Chad A. Reichard, Yu Shen, Jonathan J. Duplisea

Introduction: Neoadjuvant chemotherapy (NAC) prior to radical or partial cystectomy is considered the standard of care for eligible patients with muscle-invasive urothelial carcinoma. Despite guideline recommendations, adoption of NAC has historicall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0802ca1b6efe08363937b2930bed9d
https://europepmc.org/articles/PMC6363565/

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Oncologic outcomes and subsequent treatment following organ sparing surgery for penile carcinoma: The University of Texas M.D. Anderson Cancer Center Experience

Autor: Curtis A. Pettaway, Barrett McCormick, John Papadopoulos, Mehrad Adibi, Pheroze Tamboli, Priya Rao, Wei Qiao, Andrea Kokorovic, Jonathan J. Duplisea, Gabriela Ramirez

Publikováno v: Urologic Oncology: Seminars and Original Investigations. 39:302.e19-302.e27

Objectives To determine the oncologic outcomes of organ sparing surgery (OSS) for penile cancer and to determine the management of and risk factors for local recurrence at a tertiary referral center in the United States. Methods and Materials Patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4dce7ac7fd762d2c41c15935e8496e
https://doi.org/10.1016/j.urolonc.2021.02.004

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