Zobrazeno 1 - 4
of 4
pro vyhledávání: '"J. Drew Thompson"'
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
Autor:
Nathaniel D. Anderson, Yael Babichev, Fabio Fuligni, Federico Comitani, Mehdi Layeghifard, Rosemarie E. Venier, Stefan C. Dentro, Anant Maheshwari, Sheena Guram, Claire Wunker, J. Drew Thompson, Kyoko E. Yuki, Huayun Hou, Matthew Zatzman, Nicholas Light, Marcus Q. Bernardini, Jay S. Wunder, Irene L. Andrulis, Peter Ferguson, Albiruni R. Abdul Razak, Carol J. Swallow, James J. Dowling, Rima S. Al-Awar, Richard Marcellus, Marjan Rouzbahman, Moritz Gerstung, Daniel Durocher, Ludmil B. Alexandrov, Brendan C. Dickson, Rebecca A. Gladdy, Adam Shlien
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Heterogeneity in leiomyosarcomas (LMS) makes treatment of the disease challenging. Here the authors analyze LMS heterogeneity and molecular LMS subtypes using genomics and transcriptomics, finding origins in distinct lineages and associations with su
Externí odkaz:
https://doaj.org/article/c08bf52065ac4dcd90672db6a2810128
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
Autor:
James J. Dowling, Richard Marcellus, Nathaniel D. Anderson, Rosemarie Venier, Anant Maheshwari, Rebecca A. Gladdy, Sheena Guram, Ludmil B. Alexandrov, Mehdi Layeghifard, Marcus Q. Bernardini, Adam Shlien, Nicholas Light, Jay S. Wunder, Rima Al-awar, Irene L. Andrulis, Matthew Zatzman, Kyoko E. Yuki, Brendan C. Dickson, Peter C. Ferguson, Daniel Durocher, Stefan C. Dentro, Carol J. Swallow, Fabio Fuligni, Yael Babichev, Albiruni Ryan Abdul Razak, Moritz Gerstung, Federico Comitani, Marjan Rouzbahman, Huayun Hou, Claire Wunker, J. Drew Thompson
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Leiomyosarcomas (LMS) are genetically heterogeneous tumors differentiating along smooth muscle lines. Currently, LMS treatment is not informed by molecular subtyping and is associated with highly variable survival. While disease site continues to dic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deaef076c2fb968616ff47ccd14b8256
https://doi.org/10.1038/s41467-021-24677-6
https://doi.org/10.1038/s41467-021-24677-6
Autor:
Paul C. Boutros, Michal Krassowski, Keren Isaev, Dike Aduluso-Nwaobasi, Irakli Dzneladze, Luyao Ruan, Lina Wadi, Yao Li, Jüri Reimand, Oliver Ocsenas, Diala Abd-Rabbo, Marta Paczkowska, Lincoln D. Stein, Liis Uusküla-Reimand, Helen He Zhu, Jared T. Simpson, J. Drew Thompson, Mathieu Lupien, Michael D. Wilson, Shimin Shuai, Minggao Liang, Vincent Huang, Azad Alizada
Publikováno v:
Molecular cell. 77(6)
A comprehensive catalog of cancer driver mutations is essential for understanding tumorigenesis and developing therapies. Exome-sequencing studies have mapped many protein-coding drivers, yet few non-coding drivers are known because genome-wide disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95f4eb06cf15794b791c5e76ad1fa04
https://pubmed.ncbi.nlm.nih.gov/31954095
https://pubmed.ncbi.nlm.nih.gov/31954095
Autor:
Marta Paczkowska, Huang, Wilson, Paul C. Boutros, Shimin Shuai, J. Drew Thompson, Ken Kron, Jüri Reimand, Irakli Dzneladze, Luyao Ruan, Minggao Liang, Michal Krassowski, Keren Isaev, Lina Wadi, Parisa Mazrooei, Lincoln D. Stein, Liis Uusküla-Reimand, Robert G. Bristow, Yao Li, Jared T. Simpson, Mathieu Lupien, Alex Murison
A comprehensive catalogue of the mutations that drive tumorigenesis and progression is essential to understanding tumor biology and developing therapies. Protein-coding driver mutations have been well-characterized by large exome-sequencing studies,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7c3bb620ccb9fd3fdf20332c6ca5b9
