Zobrazeno 1 - 10
of 31
pro vyhledávání: '"J. Drakes"'
Autor:
Renier J. Brentjens, Christopher A. Klebanoff, Smita S. Chandran, Andrea V. Lopez, Terence J. Purdon, Sarwish Rafiq, Dylan J. Drakes
T-cell receptor (TCR)–modified T-cell gene therapy can target a variety of extracellular and intracellular tumor-associated antigens, yet has had little clinical success. A potential explanation for limited antitumor efficacy is a lack of T-cell ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e286718b2590d3adedba47c906aff5
https://doi.org/10.1158/2326-6066.c.6550192
https://doi.org/10.1158/2326-6066.c.6550192
Autor:
Renier J. Brentjens, Christopher A. Klebanoff, Smita S. Chandran, Andrea V. Lopez, Terence J. Purdon, Sarwish Rafiq, Dylan J. Drakes
Supplementary Data Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eca7a76d0dc342785770e08b5384623
https://doi.org/10.1158/2326-6066.22543267
https://doi.org/10.1158/2326-6066.22543267
Autor:
Renier J. Brentjens, Christopher A. Klebanoff, Smita S. Chandran, Andrea V. Lopez, Terence J. Purdon, Sarwish Rafiq, Dylan J. Drakes
Supplementary Figures 1-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db075330d591cebfe93bc4fd29a7c65
https://doi.org/10.1158/2326-6066.22543264.v1
https://doi.org/10.1158/2326-6066.22543264.v1
Autor:
Dylan J. Drakes, Abdulraouf M. Abbas, Jacqueline Shields, Martin P. Steinbuck, Aniela Jakubowski, Lochana M. Seenappa, Christopher M. Haqq, Peter C. DeMuth
While T cell receptor (TCR)-modified T cell therapies have shown promise against solid tumors, overall therapeutic benefits in clinical practice have been modest due in part to suboptimal T cell persistence and activation in vivo, alongside the possi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c75470b10dcf0ff3789539378b3fae3d
https://doi.org/10.1101/2022.05.05.490779
https://doi.org/10.1101/2022.05.05.490779
Akademický článek
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Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Terence J. Purdon, Smita S. Chandran, Dylan J. Drakes, Renier J. Brentjens, Andrea V. Lopez, Christopher A. Klebanoff, Sarwish Rafiq
Publikováno v:
Cancer Immunol Res
T-cell receptor (TCR)–modified T-cell gene therapy can target a variety of extracellular and intracellular tumor-associated antigens, yet has had little clinical success. A potential explanation for limited antitumor efficacy is a lack of T-cell ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074fc2b456c8b2fd4578e66b4da31aad
https://europepmc.org/articles/PMC7269835/
https://europepmc.org/articles/PMC7269835/
Publikováno v:
Cancer Immunology Research. 8:A37-A37
Clinical trials utilizing T cells genetically engineered to express a tumor-targeted T-cell receptor (TCR) illustrate the promise of this therapy in treating cancer patients. However, there are obstacles that must be overcome to improve the efficacy
Autor:
Terence J. Purdon, Su Yan, Cheng Liu, Pei Wang, Xiaojing Ma, Ronald C. Hendrickson, Renier J. Brentjens, Jingyi Xiang, Zhuoning Li, Venkatraman E. Seshan, Mei Song, Matthew M. Miele, Dayenne G. van Leeuwen, Sarwish Rafiq, Dylan J. Drakes, Hollie J. Jackson, Oladapo Yeku
Publikováno v:
Nature biotechnology
The efficacy of chimeric antigen receptor (CAR) T cell therapy against poorly responding tumors can be enhanced by administering the cells in combination with immune checkpoint blockade inhibitors. Alternatively, the CAR construct has been engineered
Autor:
Lee Apostle Mcdermott, Tianyi Yang, Richard A. Cerione, Lawrence Vernetti, William P. Katt, Jason W. O'Neill, Prema Iyer, Dylan J. Drakes, Michael Fioravanti, Melissa Boby, Jingran Sun, Qingqiu Huang, Shawn Rimer, Liwei Wang
A novel set of GAC (kidney glutaminase isoform C) inhibitors able to inhibit the enzymatic activity of GAC and the growth of the triple negative MDA-MB-231 breast cancer cells with low nanomolar potency is described. Compounds in this series have a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1deadb5112f65be8193275aa99f3b2b
https://europepmc.org/articles/PMC6300166/
https://europepmc.org/articles/PMC6300166/