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pro vyhledávání: '"J. Don Chen"'
Supplementary Data from Estrogen-related receptor-α antagonist inhibits both estrogen receptor–positive and estrogen receptor–negative breast tumor growth in mouse xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23713c69bb8f6ce03db111a76be2e540
https://doi.org/10.1158/1535-7163.22484927
https://doi.org/10.1158/1535-7163.22484927
Estrogen-related receptors (ERR) are orphan members of the nuclear receptor superfamily most closely related to estrogen receptors (ER). Although ERα is a successful target for treating breast cancer, there remains an unmet medical need especially f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00153ec0baacb68c1003cc7d76f61eb
https://doi.org/10.1158/1535-7163.c.6531659
https://doi.org/10.1158/1535-7163.c.6531659
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5624 (2009)
The orphan nuclear receptor estrogen-related receptor alpha (ERRalpha) is a member of the nuclear receptor superfamily. It was identified through a search for genes encoding proteins related to estrogen receptor alpha (ERalpha). An endogenous ligand
Externí odkaz:
https://doaj.org/article/ed8a3f51a2924496a2d2725845007fee
Publikováno v:
Nucleic Acids Research
The alternation/deficiency in activation-3 (ADA3) is an essential component of the human p300/CBP-associated factor (PCAF) and yeast Spt-Ada-Gcn5-acetyltransferase (SAGA) histone acetyltransferase complexes. These complexes facilitate transactivation
Autor:
Susan P. Rohrer, Sheng Jian Cai, James Schaeffer, Elizabeth T. Birzin, J. Don Chen, Osvaldo A. Flores, Paul Zuck, Ralph T. Mosley, Michael J. Chisamore, Hilary A. Wilkinson, Gregory O'Donnell
Publikováno v:
Drug Development Research. 69:203-218
The estrogen-related receptor α (ERRα) was one of the first orphan receptors identified through a search for genes encoding proteins related to the steroid nuclear receptor, Estrogen Receptor α (ERα). The physiological role of ERRα has not yet b
Regulation of Nrf2 Transactivation Domain Activity by p160 RAC3/SRC3 and Other Nuclear Co-Regulators
Autor:
J Don Chen, Mohit Jain, Wen Lin, Guoxiang Shen, Aihua Zhang, Ah-Ng Tony Kong, Siwang Yu, Xiaoling Yuan
Publikováno v:
Scopus-Elsevier
Transcription factor NF-E2-related factor 2 (Nrf2) regulates the induction of Phase II detoxifying enzymes and antioxidant enzymes in response to many cancer chemopreventive compounds. In this study, we investigated the role of receptor associated co
Publikováno v:
Biochemical and Biophysical Research Communications. 318:714-718
RORgamma is a nuclear receptor that binds to DNA motifs as a monomer to constitutively activate target genes. RORgamma plays an important role in thymocyte development and lymph node organogenesis, while the regulation of RORgamma-mediated transcript
Autor:
Jiemin Wong, Didier Auboeuf, Sophia Y. Tsai, J. Don Chen, Zheng Liu, Ming-Jer Tsai, Bert W. O'Malley
Publikováno v:
Proceedings of the National Academy of Sciences. 99:7940-7944
Selective receptor modulators, such as the antiprogestin RU486, are known to exhibit partial agonist activities in a cell-type-dependent manner. Employing an in vitro chromatin transcription system that recapitulates progesterone receptor (PR)-mediat
Autor:
J. Don Chen, Xiaofang Yang, Jagadish C. Ghosh, H. Eric Xu, Hui Li, Millard H. Lambert, Aihua Zhang
Publikováno v:
Proceedings of the National Academy of Sciences. 99:5842-5847
The retinoid X receptor (RXR) is a key regulator in multiple signaling pathways because it can form either a homodimer with itself or a heterodimer with members of the class I nuclear receptors. The RXR-containing dimers regulate transcription by rec
Autor:
Benjamin G. Cuiffo, Yumei Wang, Alison R. Meloni, Yong Yi, Yun Joong Kim, Kimberly B. Kegel, Neil Aronin, Ellen Sapp, Erin Doyle, J. Don Chen, Joseph R. Nevins, Zheng-Hong Qin, Marian DiFiglia
Publikováno v:
Journal of Biological Chemistry. 277:7466-7476
Huntingtin is a protein of unknown function that contains a polyglutamine tract, which is expanded in patients with Huntington's disease (HD). We investigated the localization and a potential function for huntingtin in the nucleus. In human fibroblas