Sputum RNA signature in allergic asthmatics following allergen bronchoprovocation test

Autor: Rob G.J.A. Zuiker, Catherine Tribouley, Zuzana Diamant, J. Diderik Boot, Adam F. Cohen, K. Van Dyck, I. De Lepeleire, Veronica M. Rivas, Vladislav A. Malkov, Jacobus Burggraaf, Marcella K. Ruddy

Publikováno v: European Clinical Respiratory Journal, Vol 3, Iss 0, Pp 1-17 (2016)

Background: Inhaled allergen challenge is a validated disease model of allergic asthma offering useful pharmacodynamic assessment of pharmacotherapeutic effects in a limited number of subjects. Objectives: To evaluate whether an RNA signature can be

Externí odkaz: https://doaj.org/article/3f8d7fa1f5d8416f955e80a13ac77f16

Reproducibility of biomarkers in induced sputum and in serum from chronic smokers

Autor: Marieke de Kam, Cesar Calderon, Zuzana Diamant, Jacobus Burggraaf, Rob Zuiker, J. Diderik Boot, Nicoletta Morelli, Ingrid M C Kamerling, Adam F. Cohen

Publikováno v: Zuiker, R G J A, Kamerling, I M C, Morelli, N R, Calderon, C, Boot, J D, de Kam, M, Diamant, Z, Burggraaf, J & Cohen, A F 2015, ' Reproducibility of biomarkers in induced sputum and in serum from chronic smokers ', Pulmonary Pharmacology and Therapeutics, vol. 33, pp. 81-86 . https://doi.org/10.1016/j.pupt.2015.05.001
Pulmonary Pharmacology and Therapeutics, 33, 81-86. Academic Press Inc.
Pulmonary Pharmacology & Therapeutics, 33, 81-86. ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD

Rationale: Soluble inflammatory markers obtained from non-invasive airway sampling such as induced sputum may be useful biomarkers for targeted pharmaceutical interventions. However, before these soluble markers can be used as potential targets, thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a311cc4dd4b31ca9443330d21ccd067d
https://research.vumc.nl/en/publications/05b832f4-b4da-4b53-9c4e-0916b89b1123

Summing up 100 years of asthma

Autor: J. Diderik Boot, J. Christian Virchow, Zuzana Diamant

Publikováno v: Respiratory Medicine. (3):378-388

SummaryIn this review, we aim to lead the readers through the historical highlights of pathophysiological concepts and treatment of asthma. Understanding the nature and links of asthma has modeled our diagnostic, pathophysiological and therapeutic th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f07a21f49549bb98fa65f81c9fb6666