ChemInform Abstract: Synthesis of 5S-(1-Oxoalkyl and Aryl)-2-pyrrolidinone Derivatives

Autor: J. Deskus, D. Fan, M. B. Smith

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd4efcfc2c6d27936ca33f6ab174ce3b
https://doi.org/10.1002/chin.199835159

Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships

Autor: A.K. Ganguly, Piwinski John J, D. Cesarz, J. del Rosario, V. Girijavallabhan, Hung V. Le, William T. Windsor, J. Deskus, Margaret M. Albanese, Corey Strickland, Doll Ronald J, Randall R. Rossman, Patricia C. Weber, Bancha Vibulbhan, Zhen Wu, Taveras Arthur G, Stacy W. Remiszewski, F. G. Njoroge, Alan K. Mallams, Carmen S. Alvarez

Publikováno v: Journal of medicinal chemistry. 42(12)

Crystallographic and thermodynamic studies of farnesyl protein transferase (FPT) complexed with novel tricyclic inhibitors provide insights into the observed SAR for this unique class of nonpeptidic FPT inhibitors. The crystallographic structures rev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0610976abbe9fe86f367417da6a37c
https://pubmed.ncbi.nlm.nih.gov/10377218

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(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5, 6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamid e (SCH-66336): a very potent farnesyl protein transferase inhibitor as a novel antitumor agent.

Autor: Njoroge FG; Departments of Chemistry and Tumor Biology, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA., Taveras AG, Kelly J, Remiszewski S, Mallams AK, Wolin R, Afonso A, Cooper AB, Rane DF, Liu YT, Wong J, Vibulbhan B, Pinto P, Deskus J, Alvarez CS, del Rosario J, Connolly M, Wang J, Desai J, Rossman RR, Bishop WR, Patton R, Wang L, Kirschmeier P, Ganguly AK, et. al.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1998 Nov 19; Vol. 41 (24), pp. 4890-902.