Zobrazeno 1 - 10
of 416
pro vyhledávání: '"J. Deshpande"'
Autor:
Nuria Tubío-Santamaría, Ashok Kumar Jayavelu, Tina M. Schnoeder, Theresa Eifert, Chen-Jen Hsu, Florian Perner, Qirui Zhang, Daniela V. Wenge, Fynn M. Hansen, Joanna M. Kirkpatrick, Nidhi Jyotsana, Steven W. Lane, Björn von Eyss, Aniruddha J. Deshpande, Michael W. M. Kühn, Juerg Schwaller, Clemens Cammann, Ulrike Seifert, Frédéric Ebstein, Elke Krüger, Andreas Hochhaus, Michael Heuser, Alessandro Ori, Matthias Mann, Scott A. Armstrong, Florian H. Heidel
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-21 (2023)
Abstract Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance frequently develops to single agents. This points to a need for thera
Externí odkaz:
https://doaj.org/article/32a44bd3490c43d78d23fc64b13aaac5
Autor:
Karina Barbosa, Aniruddha J. Deshpande
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
One of the distinguishing properties of hematopoietic stem cells is their ability to self-renew. Since self-renewal is important for the continuous replenishment of the hematopoietic stem cell pool, this property is often hijacked in blood cancers. A
Externí odkaz:
https://doaj.org/article/552511eac6434f9799b303d86ef53df5
Autor:
Shyam J Deshpande, Aspen Avery, Julian Takagi-Stewart, Brianna Mills, Qian Qiu, Monica S Vavilala
Publikováno v:
Concussion, Vol 8, Iss 2 (2023)
Aim: To understand academic support structures for Washington state public high school students with concussion during the COVID-19 pandemic. Materials & methods: Prospective, repeated cross-sectional study of 21 schools in 2020 and 2021. Results: Ab
Externí odkaz:
https://doaj.org/article/1a011b8b15974453b77d1bfe64abd13b
Autor:
Sanju Sinha, Karina Barbosa, Kuoyuan Cheng, Mark D. M. Leiserson, Prashant Jain, Anagha Deshpande, David M. Wilson, Bríd M. Ryan, Ji Luo, Ze’ev A. Ronai, Joo Sang Lee, Aniruddha J. Deshpande, Eytan Ruppin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
CRISPR-Cas9 gene editing can induce a p53 mediated damage response. Here the authors investigate the possibility of selection of pre-existing cancer driver mutations during CRISPR-Cas9 knockout based gene editing and identify KRAS mutants that may co
Externí odkaz:
https://doaj.org/article/5fe16eb955dc4e7db09618e84c592388
Autor:
Ali Khateb, Anagha Deshpande, Yongmei Feng, Darren Finlay, Joo Sang Lee, Ikrame Lazar, Bertrand Fabre, Yan Li, Yu Fujita, Tongwu Zhang, Jun Yin, Ian Pass, Ido Livneh, Irmela Jeremias, Carol Burian, James R. Mason, Ronit Almog, Nurit Horesh, Yishai Ofran, Kevin Brown, Kristiina Vuori, Michael Jackson, Eytan Ruppin, Aniruddha J. Deshpande, Ze’ev A. Ronai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Epigenetic changes are implicated in Acute myeloid leukemia (AML) tumorigenesis. Here, the authors show that the ubiquitin ligase RNF5 and its substrate RBBP4 contribute to AML development by regulating epigenetic-controlled transcription which deter
Externí odkaz:
https://doaj.org/article/906878f0ea8448bb9623f72fa90b2362
Autor:
Vishi Sharma, Sunita Nehra, Long H. Do, Anwesha Ghosh, Aniruddha J. Deshpande, Nishant Singhal
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Impaired neurogenesis in Down syndrome (DS) is characterized by reduced neurons, increased glial cells, and delayed cortical lamination. However, the underlying cause for impaired neurogenesis in DS is not clear. Using both human and mouse iPSCs, we
Externí odkaz:
https://doaj.org/article/5fc1e41d38dd486bb2101ef0df8c8705
Autor:
Brianna J. Klein, Anagha Deshpande, Khan L. Cox, Fan Xuan, Mohamad Zandian, Karina Barbosa, Sujita Khanal, Qiong Tong, Yi Zhang, Pan Zhang, Amit Sinha, Stefan K. Bohlander, Xiaobing Shi, Hong Wen, Michael G. Poirier, Aniruddha J. Deshpande, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Chromosomal translocations involving the AF10 gene, especially with CALM, are associated with aggressive leukemias. Here the authors show that the PZP domain of AF10, a histone reader, is always excluded/impaired in AF10 fusions, whereas incorporatio
Externí odkaz:
https://doaj.org/article/bc1ee92ef2674d4cb5c121a8d5e098c2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Disruptor of telomeric silencing 1 (DOT1) was first identified in yeast (DOT1p) and is the sole methyltransferase responsible for histone three lysine 79 (H3K79) mono-, di-, and tri-methylation. Mammalian DOT1 (DOT1-like protein or DOT1L) has been im
Externí odkaz:
https://doaj.org/article/40714782193c4b4baee34f17b19e6d16
Autor:
M. Prabhu, R. Ajith Kumar, T. H. Gopikrishnan, P. J. Deshpande, U. Anandhakrishnan, A. S. Kiran, R. P. Govindu
Publikováno v:
Journal of Applied Fluid Mechanics, Vol 13, Iss 1, Pp 147-160 (2020)
This paper reveals the results of a study of vortex air core formation (Rankine vortex) when a rotated liquid (water) column in a cylindrical vessel is drained through two ports located at equal eccentricity (e) at the vessel base (diameter, d_1and d
Externí odkaz:
https://doaj.org/article/bd2eca54b0be41c7b8bcbc9d2394498d
Autor:
Shyam J Deshpande, Julia Velonjara, Silvia Lujan, Gustavo Petroni, Jin Wang, Kushang V Patel, Linda Ng Boyle, Michael J Bell, Monica S Vavilala, PEGASUS Argentina Study Group
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0275255 (2022)
BackgroundTo understand provider perceptions of the COVID-19 pandemic on priorities of severe pediatric traumatic brain injury (TBI) care across hospitals in South America.MethodsSite principal investigators (PIs) from 17 hospitals in South America e
Externí odkaz:
https://doaj.org/article/a3322129386640fca2fbda586086ecf6