Zobrazeno 1 - 5
of 5
pro vyhledávání: '"J. Derek Thornton"'
Publikováno v:
Cell Cycle. 4:1316-1319
Arf is a key mammalian tumor suppressor gene known to be activated in response to aberrant mitogenic signals leading to both p53-dependent and -independent effects. We recently uncovered a new and somewhat unexpected function for mouse Arf as a regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a4207bacb75e03ef180d2841f6d316
https://doi.org/10.4161/cc.4.10.2109
https://doi.org/10.4161/cc.4.10.2109
Autor:
J. Derek Thornton, Jerold E. Rehg, Amy C. Martin, Ricardo L.A. Silva, Stephen X. Skapek, Frederique Zindy, David Bertwistle
Publikováno v:
The EMBO Journal. 24:2803-2814
We have established that the Arf tumor suppressor gene regulates mural cell biology in the hyaloid vascular system (HVS) of the developing eye. In the absence of Arf, perivascular cells accumulate within the HVS and prevent its involution. We now dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8652c9ae4dd94b65aab7fe92dde4caf4
https://doi.org/10.1038/sj.emboj.7600751
https://doi.org/10.1038/sj.emboj.7600751
Autor:
Raya Saab, Yi D. Zhao, Colleen Anderson, Yanbin Zheng, Melissa Gibbons, Phillip M. Garfin, J. Derek Thornton, Natalie E. Freeman-Anderson, Tong Chuan He, Stephen X. Skapek, Shannon H. Baumer, Louise M. Treanor, Amy C. McCalla-Martin, John M. Cunningham, Michelle N. Mary
Publikováno v:
Development (Cambridge, England). 136(12)
The Arf tumor suppressor (also known as Cdkn2a) acts as an oncogene sensor induced by ;abnormal' mitogenic signals in incipient cancer cells. It also plays a crucial role in embryonic development: newborn mice lacking Arf are blind due to a pathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47cee9a15750d519fe87838e0a4372d
https://pubmed.ncbi.nlm.nih.gov/19465598
https://pubmed.ncbi.nlm.nih.gov/19465598
Autor:
Amy C. Martin, Stephen X. Skapek, Dan Goldowitz, Doug Swanson, Michelle N. Mary, Stanley Pounds, J. Derek Thornton, Deqing Pei
Publikováno v:
Investigative Opthalmology & Visual Science. 48:491
Purpose Mice lacking the Arf tumor-suppressor gene develop eye disease reminiscent of persistent hyperplastic primary vitreous (PHPV). The current work explores mechanisms by which Arf promotes eye development, and its absence causes a PHPV-like dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56a1851d5609ede41e69ffa03592cbf
https://doi.org/10.1167/iovs.06-0765
https://doi.org/10.1167/iovs.06-0765
Pathogenesis of Persistent Hyperplastic Primary Vitreous in Mice Lacking theArfTumor Suppressor Gene
Autor:
Monica M. Jablonski, Edward Chaum, Jian Zuo, J. Derek Thornton, Amy C. Martin, Stephen X. Skapek, Frederique Zindy, XiaoFei Wang, Jiewiu Liu
Publikováno v:
Investigative Opthalmology & Visual Science. 45:3387
PURPOSE. Persistent hyperplastic primary vitreous (PHPV) is an idiopathic developmental eye disease associated with failed involution of the hyaloid vasculature. The present work addressed the pathogenesis of PHPV in a mouse model that replicates man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946880bed63f7d7f725bc73ac6405360
https://doi.org/10.1167/iovs.04-0349
https://doi.org/10.1167/iovs.04-0349