Zobrazeno 1 - 10
of 24
pro vyhledávání: '"J. David Peske"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Regulatory T cells (Treg) are crucial immune modulators, yet the exact mechanism of thymic Treg development remains controversial. Here, we present the first direct evidence for H2-O, an MHC class II peptide editing molecular chaperon, on selection o
Externí odkaz:
https://doaj.org/article/f15013f2bbe74e1aa7b4a70190f11ecd
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
T cell activation induces homing receptors that bind ligands on peripheral tissue vasculature, programming movement to sites of infection and injury. There are 3 major types of CD8 effector T cells based on homing receptor expression, which arise in
Externí odkaz:
https://doaj.org/article/dcc66980cfa4488f8d44fb29e3782eb6
Autor:
Victor H. Engelhard, Andrew R. Ferguson, Randal K. Gregg, Eric F. Tewalt, J. David Peske, Arun B. Dutta, Jianhao Zeng, Nithya Srivinisan, Ashley L. Wilson, Amber N. Woods
Although CD8+ T cells are critical for controlling tumors, how they are recruited and home to primary and metastatic lesions is incompletely understood. We characterized the homing receptor (HR) ligands on tumor vasculature to determine what drives t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0edc53b1657573a41e255b84f0d5afb
https://doi.org/10.1158/2326-6066.c.6548726.v1
https://doi.org/10.1158/2326-6066.c.6548726.v1
Autor:
Victor H. Engelhard, Andrew R. Ferguson, Randal K. Gregg, Eric F. Tewalt, J. David Peske, Arun B. Dutta, Jianhao Zeng, Nithya Srivinisan, Ashley L. Wilson, Amber N. Woods
S1: LLC-OVA or MC-38-OVA tumors were harvested on day 14 (SC) or day 11 (IP). LLC-OVA tumors were flash frozen and stained for MadCAM-1 expression. Representative and summary data interrogating 8-10 random fields from single sections of 3 tumors each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281d96743aff82c3ec8629a0e778f316
https://doi.org/10.1158/2326-6066.22538255.v1
https://doi.org/10.1158/2326-6066.22538255.v1
Autor:
Jian Guan, Michael Manoharan Valerio, J. David Peske, Chansu Park, Ellen A. Robey, Scheherazade Sadegh-Nasseri, Nilabh Shastri
Publikováno v:
bioRxiv
Intestinal intraepithelial lymphocytes (IELs) are characterized by an unusual phenotype and developmental pathway, yet their specific ligands and functions remain largely unknown. Here by analysis of QFL T cells, a population of CD8+T cells critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfc1b3e3056809a1fb42e143775d624
https://doi.org/10.1101/2023.03.01.530600
https://doi.org/10.1101/2023.03.01.530600
Publikováno v:
Mol Immunol
Publikováno v:
Virchows Archiv. 474:463-474
For many years, the gold standard cancer grading and staging had focused on the characteristics of the cancer cells and often disregarded the non-tumoral cell compartments. The expansion of research on the tumor immune microenvironment, the successes
Autor:
Rafael Sanchez-Salas, Yann Vano, Nicolas A. Giraldo, J David Peske, Catherine Sautès-Fridman, Wolf H. Fridman, Alexandre Ingels, Florent Petitprez, Pierre Validire, Etienne Becht, Xavier Cathelineau
Publikováno v:
British Journal of Cancer
British Journal of Cancer, 2019, 120 (1), pp.45-53. ⟨10.1038/s41416-018-0327-z⟩
British Journal of Cancer, Cancer Research UK, 2019, 120 (1), pp.45-53. ⟨10.1038/s41416-018-0327-z⟩
British Journal of Cancer, 2019, 120 (1), pp.45-53. ⟨10.1038/s41416-018-0327-z⟩
British Journal of Cancer, Cancer Research UK, 2019, 120 (1), pp.45-53. ⟨10.1038/s41416-018-0327-z⟩
International audience; The highly complex and heterogenous ecosystem of a tumour not only contains malignant cells, but also interacting cells from the host such as endothelial cells, stromal fibroblasts, and a variety of immune cells that control t
Autor:
Robin S. Lindsay, Max O. Meneveau, Yang Xin Fu, Anthony B. Rodriguez, J. David Peske, Salwador Cyranowski, Geoffrey Parriott, Amber N. Woods, Mark R. Conaway, Victor H. Engelhard, Katie M. Leick, Marit M. Melssen, Craig L. Slingluff, S. Young, Ileana S. Mauldin
Publikováno v:
Cell reports
SUMMARY Tumor-associated tertiary lymphoid structures (TA-TLS) are associated with enhanced patient survival and responsiveness to cancer therapies, but the mechanisms underlying their development are unknown. We show here that TA-TLS development in
Autor:
Ileana S. Mauldin, J. David Peske, Anthony B. Rodriguez, Craig L. Slingluff, Victor H. Engelhard, Amber N. Woods
Publikováno v:
The Journal of Immunology. 200:432-442
Limited representation of intratumoral immune cells is a major barrier to tumor control. However, simply enhancing immune responses in tumor-draining lymph nodes or through adoptive transfer may not overcome the limited ability of tumor vasculature t