Zobrazeno 1 - 10
of 20
pro vyhledávání: '"J. David Holtzclaw"'
Publikováno v:
American Journal of Physiology-Renal Physiology. 299:F507-F516
Large-conductance, calcium-activated potassium channels (BK) are expressed in principal cells (PC) and intercalated cells (IC) in mammalian nephrons as BK-alpha/beta1 and BK-alpha/beta4, respectively. IC, which protrude into the lumens of tubules, ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73993d84bf5a15f316b2f50dc9be2241
https://doi.org/10.1152/ajprenal.00222.2010
https://doi.org/10.1152/ajprenal.00222.2010
Publikováno v:
American Journal of Physiology-Renal Physiology. 297:F420-F428
On a low-Na+ diet (LNa+), urinary Na+ loss is prevented by aldosterone-induced Na+ reabsorption through epithelial Na+ channels (ENaC) in the connecting tubules (CNT) and cortical collecting ducts (CCD). However, the mechanism whereby K+ loss is mini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39fe5f3960008eeec6a443af0915af5
https://doi.org/10.1152/ajprenal.00191.2009
https://doi.org/10.1152/ajprenal.00191.2009
Publikováno v:
Proceedings of the National Academy of Sciences. 106:11800-11805
Mice lacking the β1-subunit (gene, Kcnmb1 ; protein, BK-β1) of the large Ca-activated K channel (BK) are hypertensive. This phenotype is thought to result from diminished BK currents in vascular smooth muscle where BK-β1 is an ancillary subunit. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381c3783d6b19077beb6065f1d1e1ff7
https://doi.org/10.1073/pnas.0904635106
https://doi.org/10.1073/pnas.0904635106
Publikováno v:
Blood. 100:3017-3025
Recent studies have identified older, low-density sickle red blood cells (SSRBCs) that were resistant to dehydration by valinomycin, a K+ ionophore. These cells, thought to derive from dense SSRBCs that have rehydrated, may represent a terminal cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b843aa7b01defa756a0aed6c4bdb0413
https://doi.org/10.1182/blood-2002-02-0631
https://doi.org/10.1182/blood-2002-02-0631
This review summarizes recent studies of hypertension associated with a defect in renal K excretion due to genetic deletions of various components of the large, Ca-activated K channel (BK), and describes new evidence and theories regarding K secretor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d3a77b63cc40188c1f70afd8599767
https://europepmc.org/articles/PMC3839424/
https://europepmc.org/articles/PMC3839424/
Publikováno v:
The FASEB Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb01e42abb37db8d685a39d85e2d3054
https://doi.org/10.1096/fasebj.25.1_supplement.1041.8
https://doi.org/10.1096/fasebj.25.1_supplement.1041.8
Publikováno v:
The FASEB Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdc3e86e3fb471678509122e446e9a48
https://doi.org/10.1096/fasebj.25.1_supplement.1041.34
https://doi.org/10.1096/fasebj.25.1_supplement.1041.34
Publikováno v:
The FASEB Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9329c9050bd5c3e49df2ac9384e2285
https://doi.org/10.1096/fasebj.25.1_supplement.1041.3
https://doi.org/10.1096/fasebj.25.1_supplement.1041.3
Increased flow in the distal nephron induces K secretion through the large-conductance, calcium-activated K channel (BK), which is primarily expressed in intercalated cells (IC). Since flow also increases ATP release from IC, we hypothesized that pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d59f3629e3db7ebc08f41f86fe3dec
https://europepmc.org/articles/PMC3119139/
https://europepmc.org/articles/PMC3119139/
The large-conductance, calcium-activated potassium (BK) channels help eliminate potassium in mammals consuming potassium-rich diets. In the distal nephron, principal cells contain BK-alpha/beta1 channels and intercalated cells contain BK-alpha/beta4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689ae95fd3e75e95bd21b06c740ae7e3
https://europepmc.org/articles/PMC2844299/
https://europepmc.org/articles/PMC2844299/