Zobrazeno 1 - 10
of 42
pro vyhledávání: '"J. D. Wade"'
Autor:
P, Fu, S, Layfield, T, Ferraro, H, Tomiyama, J, Hutson, L, Otvos, G W, Tregear, R A D, Bathgate, J D, Wade
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 63(2)
Biotin-avidin immobilization has been routinely used as a tool to study peptide-receptor and peptide-antibody interactions. Biotinylated peptides can also be employed to localize cells that express the peptides' receptor, and to analyse ligand-recept
Autor:
B, Catimel, M C, Faux, M, Nerrie, J, Rothacker, L J, Otvos, J D, Wade, E C, Nice, A W, Burgess
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 58(6)
The coiled coil is a common structural motif found both as the dominant structure in fibrous proteins and as an oligomerization domain in a variety of cytoskeletal and extracellular matrix proteins. Coiled-coils typically consist of two to four helic
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 7(9)
Previous studies have shown the amyloid peptides, Abeta 1-40/42, to be exceptionally difficult to assemble by Fmoc-solid phase peptide synthesis due to the high hydrophobicity of the C-terminal segment and resulting on-resin aggregation. We found tha
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 58(3)
Large numbers of colon tumors stem from mutations in the gene coding for the production of the adenomatous polyposis coli (APC) tumor suppressor protein. This protein contains a coiled-coil N-terminal domain that is known to be responsible for homodi
Autor:
M N, Mathieu, J D, Wade, B, Catimel, C P, Bond, E C, Nice, R J, Summers, L, Otvos, G W, Tregear
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 57(5)
Biotin-avidin immobilization can be a useful tool in structure-function studies of hormone receptors. A crucial step is the preparation of a specifically biotinylated hormone that is able to bind to its receptor while leaving the biotin group free fo
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 6(5)
The 'template-assembled synthetic protein' (TASP) concept provides a simple and elegant approach for the preparation of analogues that retain key structural elements. We have synthesized TASP molecules containing the putative active site of relaxin,
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 6(5)
Established methodology for the preparation of peptide thioesters requires the use of t-butoxycarbonyl chemistry owing to the lability of thioester linkers to the nucleophilic reagents used in Fmoc solid phase peptide synthesis. Both the greater ease
Autor:
N F, Dawson, D J, Craik, A M, McManus, S G, Dashper, E C, Reynolds, G W, Tregear, L, Otvos, J D, Wade
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 6(1)
The 32-residue peptide, RK-1, a novel kidney-derived three disulfide-bonded member of the antimicrobial alpha-defensin family, was synthesized by the continuous flow Fmoc-solid phase method. The crude, cleaved and S-reduced linear peptide was both ef
Publikováno v:
Endocrinology. 140(11)
The purpose of the study was to determine whether iv infusion of relaxin would acutely stimulate water drinking in rats and, if it did, whether such drinking is affected by other dipsogenic stimuli or is blocked by centrally administered losartan. iv
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 53(5)
The primary structure of ovine Leydig cell insulin-like peptide (Ley I-L) was recently deduced from the corresponding cDNA sequence. It consists of two peptide chains and three disulphide bonds in an arrangement similar to both relaxin and insulin. A