Clinical pharmacokinetics of mitoxantrone after intraperitoneal administration

Autor: J. G. McVie, J. D. Nagel, F. J. Varossieau, W.W. ten Bokkel Huinink, R. Dubbelman

Publikováno v: Cancer Chemotherapy and Pharmacology. 29:480-484

The pharmacokinetics of intraperitoneally (i.p.) injected mitoxantrone was determined in plasma and peritoneal dialysate taken from five patients presenting with cancer confined to the peritoneal cavity over a sampling period of 1 week. The drug was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9ea324cf5a816a6f48562a8538ad2d
https://doi.org/10.1007/bf00684852

[Mitochondrial diseases]

Autor: J D, Nagel, F, Haverkamp, M J, Lentze

Publikováno v: Klinische Padiatrie. 209(6)

Mitochondrial disease are a heterogeneous group, combining multiple symptoms resulting from defects in various organs. Thus identification of a particular mitochondrial disease due to clinical symptoms is not possible. However, simple biochemical tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88416a7547686fe2617e10bf9a71309f
https://pubmed.ncbi.nlm.nih.gov/9445918

Clinical pharmacokinetics of mitoxantrone in hyperthermic, isolated perfusion of the leg

Autor: F. Ghussen, I. Krüger, J. D. Nagel, U. Bode

Publikováno v: Cancer chemotherapy and pharmacology. 29(2)

The clinical pharmacokinetics of mitoxantrone in hyperthermic, isolated perfusion of the leg were studied in five patients exhibiting solitary, localized malignant melanoma. Mitoxantrone was given as four 1-min infusions at 15-min intervals into the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0237e2afa5b4605b850a7a3f28df110a
https://pubmed.ncbi.nlm.nih.gov/1760859

Abstracts of papers Pharmaceutical and biomedical analysis meeting

Autor: A. U. Bandhoe, A. C. A. Paalman, W. J. M. Underberg, J. H. Beijnen, O. Bekers, M. Otagiri, A. Bult, Gert Beuman, Jacques van der Heijden, Jenny Janss, P. R. J. Ceelen, G. G. L. M. Feenstra-Bielders, D. J. Groeneveld, D. de Boer, M. J. A. Rutten, E. G. de Jong, R. A. A. Maes, J. M. van Rossum, G. de Groot, R. Kopps, T. J. F. Savelkoul, P. van Vloten, E. G. de Jonag, R. van Ooyen, J. Kiffers, I. F. I. de Kroon, P. N. J. Langendijk, P. N. F. C. de Goede, M. De Smet, C. Musch, A. Peeters, L. Buydens, D. L. Massart, K. De Turck, Th. Cachet, J. Hoogmartens, M. Delrue, P. Lannoo, B. F. H. Drenth, F. J. Beckeringh, J. Bosman, K. G. Feitsma, A. van Nijhuisvan Dam, R. J. Driebergen, J. A. van Gorp, K. Ensing, A. Farlam, G. J. de Jong, R. W. Frel, U. A. Th. Brinkman, T. K. Gerding, V. J. M. van de Grampel, N. R. Niemeijer, R. A. de Zeeuw, P. G. Tepper, A. S. Horn, J. J. Halvax, G. Wiese, W. P. van Bennekom, Rik Hindriks, Lutgarde Buydens, Anne Peeters, Marina de Smet, Luc Massart, Aric Blokland, Jan Vink, S. Keizers, W. M. A. Niessen, E. R. Verhey, G. F. LaVos, U. R. Tjaden, J. van der Greef, J. A. Ooms, G. S. J. Haak, G. Grooten, G. Pattyn, P. Sandra, F. David, A. T. van Oosterom, E. A. de Bruijn, A. V. Pouwelse, D. de Jong, N. G. F. M. Lammers, J. H. M. van den Berg, I. Quintens, E. Roets, H. J. E. M. Reeuwijk, H. Lingeman, H. J. Keizer, H. Rosing, F. Elferink, F. J. van de Vaart, P. H. A. M. Kloeg, André Sauter, D. S. Stegehuis, N. J. Reinhoud, O. M. Steijger, J. J. L. Hilhorst, J. J. M. Holthuis, U. K. Underberg-Chitoe, P. L. Meenhorst, G. Van den Mooter, R. Hauchecorne, C. Vinckier, A. van der Horst, H. J. M. Martens, F. A. L. van der Horst, M. H. Post, L. A. van Ginkel, P. W. Zoontjes, H. van Blitterswijk, R. W. Stephany, R. van Gijn, C. H. Bakker, C. H. W. Koks, S. Rodenhuis, M. A. J. van Opstal, F. A. L. van den Horst, P. Krabbenborg, O. van Tellingen, H. R. v. d. Woude, C. J. T. van Beers, W. J. Nooyen, F. J. Varossieau, G. Los, J. D. Nagel, J. G. McVie, R. N. Veen, J. T. Op 't Land, D. E. M. M. Vendrig, J. Teeuwsen, F. C. A. M. Verlaar, T. J. H. M. Trum, J. P. de Kleijn, R. Vervoort, M. Vrieling, F. Maris, H. Hindriks, A. Walhagen, L. -E. Edholm, C. E. M. Heeremans, R. A. M. van der Hoeven

Publikováno v: Pharmaceutisch Weekblad. 11:A1-A14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bc2b189fe22efce3b40ab44b8b644e0
https://doi.org/10.1007/bf02196041

New, simple model of mesenteric lymph node metastases in the rat

Autor: J. G. McVie, J. D. Nagel, W. J. Mooi

Publikováno v: Clinicalexperimental metastasis. 7(4)

Injection of 1 x 10(6) CC531 colonic carcinoma cells into the mesenteric lymph nodes of Wag/Rij rats resulted in the growth of tumors within the lymph nodes. These were apparent after 3 days, whereas lung and liver metastases were not observed until

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76609d37ae42221067adc84544090532
https://pubmed.ncbi.nlm.nih.gov/2706832