Výsledky vyhledávání - "J. D. Mcgarry"

Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between

Autor: J. D. McGarry

Publikováno v: Biochemical Society Transactions. 29:241-244

Although malonyl-CoA was first recognized as a central component in the regulation of hepatic ketogenesis, its inhibitory effect on mitochondrial carnitine palmitoyltransferase I (CPT I) has come to be viewed as a key element in fuel sensing in a var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06377806282668b536a991b31ae75a77
https://doi.org/10.1042/bst0290241

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Akademický článek

An improved and simplified radioisotopic assay for the determination of free and esterified carnitine

Autor: J D McGarry, D W Foster

Publikováno v: Journal of Lipid Research, Vol 17, Iss 3, Pp 277-281 (1976)

The radioisotopic assay for carnitine first described by Cederblad and Lindstedt (Clin. Chim. Acta. 37:235–543, 1972) and modified by Bøhmer et al (Clin. Chim. Acta. 57:55–61, 1974) has been improved and simplified. As a result, the assay yields

Externí odkaz: https://doaj.org/article/bfc5974e3999402298e3641345d5c2b3

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The N-terminal Domain of Rat Liver Carnitine Palmitoyltransferase 1 Mediates Import into the Outer Mitochondrial Membrane and Is Essential for Activity and Malonyl-CoA Sensitivity

Autor: J. D. McGarry, Claude Kohl, Isabelle Cohen, Jean-Philippe Girard, Carina Prip-Buus

Publikováno v: Journal of Biological Chemistry. 273:29896-29904

The rat liver carnitine palmitoyltransferase 1 (L-CPT1), an integral outer mitochondrial membrane (OMM) protein, is the key regulatory enzyme of fatty acid oxidation and is inhibited by malonyl-CoA. In vitro import of L-CPT1 into the OMM requires the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09162ca1d33d0b21cebdd84f7338d7cb
https://doi.org/10.1074/jbc.273.45.29896

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Roles of the N- and C-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes: insights from expression of chimaeric proteins and mutation of conserved histidine residues

Autor: S. T. Swanson, Daniel W. Foster, J. D. McGarry, N. F. Brown

Publikováno v: Biochemical Journal. 335:513-519

The mitochondrial outer membrane enzyme carnitine palmitoyltransferase I (CPT I) plays a major role in the regulation of fatty acid entry into the mitochondrial matrix for β-oxidation by virtue of its inhibition by malonyl-CoA. Two isoforms of CPT I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310461204974ad05d3bcdb3985566df6
https://doi.org/10.1042/bj3350513

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Molecular or Pharmacologic Perturbation of the Link between Glucose and Lipid Metabolism Is without Effect on Glucose-stimulated Insulin Secretion

Autor: Marc Prentki, Peter A. Antinozzi, Laura Segall, J. D. McGarry, Christopher B. Newgard

Publikováno v: Journal of Biological Chemistry. 273:16146-16154

The mechanism by which glucose stimulates insulin secretion from the pancreatic islets of Langerhans is incompletely understood. It has been suggested that malonyl-CoA plays a regulatory role by inhibiting fatty acid oxidation and promoting accumulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a5842e0b68f37fbfa24ffd623ae3930
https://doi.org/10.1074/jbc.273.26.16146

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A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion

Autor: Robert L. Dobbins, M W Chester, Daniel T. Stein, J. D. McGarry, B E Stevenson, M B Daniels

Publikováno v: Journal of Clinical Investigation. 101:2370-2376

Lowering of the plasma FFA level in intact fasted rats by infusion of nicotinic acid (NA) caused essentially complete ablation of insulin secretion (IS) in response to a subsequent intravenous bolus of arginine, leucine, or glibenclamide (as previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a54dfc68eea7be106d6ad9de4c80a47
https://doi.org/10.1172/jci1813

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Glucose-fatty acid interactions in health and disease

Autor: J D McGarry

Publikováno v: The American Journal of Clinical Nutrition. 67:500S-504S

It is widely held that although obesity and type 2 diabetes are polygenic in origin, the primary defect causing both conditions is insulin resistance, which in turn gives rise to a constellation of other abnormalities, including hyperinsulinemia, dys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c42aafdaef5d9d354ec5040039aa17
https://doi.org/10.1093/ajcn/67.3.500s

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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation

Autor: Christopher J. Rhodes, M W Chester, L C Bollheimer, J. D. McGarry, R H Skelly

Publikováno v: Journal of Clinical Investigation. 101:1094-1101

The pancreatic beta cell normally maintains a stable balance among insulin secretion, insulin production, and insulin degradation to keep optimal intracellular stores of the hormone. Elevated levels of FFA markedly enhance insulin secretion; however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf897c9da1311bbce73dd614827f8c7a
https://doi.org/10.1172/jci420

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Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation: Inter-tissue and inter-species expression of CPT I and CPT II enzymes

Autor: J. K. Hill, J. L. Kirkland, Barbara E. Corkey, J. D. McGarry, Victoria Esser, N. F. Brown, Daniel W. Foster

Publikováno v: Biochemical Journal. 327:225-231

The outer mitochondrial membrane enzyme carnitine palmitoyltransferase I (CPT I) represents the initial and regulated step in the β-oxidation of fatty acids. It exists in at least two isoforms, denoted L (liver) and M (muscle) types, with very diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed1f7bde9588eb7961471c97da4b0e6
https://doi.org/10.1042/bj3270225

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