Výsledky vyhledávání - "J. D. Isaacs"

Akademický článek

TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis

Autor: M. Cole, C. Yap, C. Buckley, W. F. Ng, I. McInnes, A. Filer, S. Siebert, A. Pratt, J. D. Isaacs, D. D. Stocken

Publikováno v: Trials, Vol 22, Iss 1, Pp 1-10 (2021)

Abstract Background Adaptive model-based dose-finding designs have demonstrated advantages over traditional rule-based designs but have increased statistical complexity but uptake has been slow especially outside of cancer trials. TRAFIC is a multi-c

Externí odkaz: https://doaj.org/article/e288990549964c93a1c4b9c09a373ddf

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Neurological picture. Bilateral facial nerve palsy associated with Epstein-Barr virus infection

Autor: C T, Coddington, J D, Isaacs, A Q, Siddiqui, T C, Andrews

Publikováno v: Journal of neurology, neurosurgery, and psychiatry. 81(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe46303bacfb8047149c42bb63afa8a5
https://pubmed.ncbi.nlm.nih.gov/20571047

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Morbidity and mortality in rheumatoid arthritis patients with prolonged and profound therapy-induced lymphopenia

Autor: J D, Isaacs, S, Greer, S, Sharma, D, Symmons, M, Smith, J, Johnston, H, Waldmann, G, Hale, B L, Hazleman

Publikováno v: Arthritis and rheumatism. 44(9)

Therapies that deplete lymphocytes often improve symptoms in patients with otherwise refractory autoimmune disease but may result in long-term lymphopenia, the consequences of which are uncertain. To assess the impact of prolonged lymphopenia on morb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62b3829020f70528db2edfda94709cd3
https://pubmed.ncbi.nlm.nih.gov/12124887

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The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis: a comparison with conventional radiography

Autor: R J, Wakefield, W W, Gibbon, P G, Conaghan, P, O'Connor, D, McGonagle, C, Pease, M J, Green, D J, Veale, J D, Isaacs, P, Emery

Publikováno v: Arthritis and rheumatism. 43(12)

The ability to make an early, accurate diagnosis of rheumatoid arthritis (RA) has become increasingly important with the availability of new, expensive, and targeted therapies. However, plain radiography, the traditional method of detecting the chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3d893564152da4ff484ad4fed351757a
https://pubmed.ncbi.nlm.nih.gov/12124886

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Fcgamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups

Autor: A W, Morgan, B, Griffiths, F, Ponchel, B M, Montague, M, Ali, P P, Gardner, H C, Gooi, R D, Situnayake, A F, Markham, P, Emery, J D, Isaacs

Publikováno v: Arthritis and rheumatism. 43(10)

To investigate a possible association between a functional polymorphism in the intermediate-affinity receptor for IgG called Fc-gamma receptor type IIIA (FcgammaRIIIA [CD16]) and rheumatoid arthritis (RA).This was an allelic association study in whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cbe522afbf2e4fb45cbc95ff26661804
https://pubmed.ncbi.nlm.nih.gov/11840462

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Combination biologic therapy

Autor: J D, Isaacs, A W, Morgan, V, Strand

Publikováno v: Clinical and experimental rheumatology. 17(6 Suppl 18)

Biologic therapies refer to genetically engineered treatments such as monoclonal antibodies and receptor-immunoglobulin fusion proteins. Following many disappointments, the introduction of anti-tumor necrosis factor (anti-TNF alpha) therapies into th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9e863b6ddcb17bb4bb3ae0bb3df53eb
https://pubmed.ncbi.nlm.nih.gov/10589370

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Therapy with monoclonal antibodies. II. The contribution of Fc gamma receptor binding and the influence of C(H)1 and C(H)3 domains on in vivo effector function

Autor: J D, Isaacs, J, Greenwood, H, Waldmann

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(8)

An in vivo model is used to define Fc motifs engaged by mAbs to deplete target cells. Human IgG1 and human IgG4 were very potent, and mutations within a motif critical for Fc gammaR binding (glutamate 233 to proline, leucine/phenylalanine 234 to vali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6568498d7176151613da5a6bf8368672
https://pubmed.ncbi.nlm.nih.gov/9780151

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