Výsledky vyhledávání - "J. D. Gemmill"

Effect of subcutaneous sumatriptan, a selective 5HT1 agonist, on the systemic, pulmonary, and coronary circulation

Autor: K J Hogg, J D Gemmill, P D MacIntyre, W S Hillis, B Bhargava

Publikováno v: Circulation. 87:401-405

BACKGROUND Sumatriptan (GR43175) is a selective 5-hydroxytryptamine (5HT1) receptor agonist effective in the acute treatment of migraine. Recent in vitro experiments suggest that it has vasoactive properties in vascular beds distinct from the cerebra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae13c0fd129cf39e633b04f766f14130
https://doi.org/10.1161/01.cir.87.2.401

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Thrombolytic Therapy in Arterial Disease. I: Available Agents

Autor: J D Gemmill, P D MacIntyre, W S Hillis, B Bhargava

Publikováno v: Vascular Medicine Review. :146-155

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c18df777f939291a69a89c8595e135a5
https://doi.org/10.1177/1358863x9200300205

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Monitoring of streptokinase resistance titre in acute myocardial infarction patients up to 30 months after giving streptokinase or anistreplase and related studies to measure specific antistreptokinase IgG

Autor: A P Rae, J.M.A. Burns, F G Dunn, W S Hillis, R Fears, E. Glasgow, H Ferres, J D Gemmill, R. Standring, Karen Hogg

Publikováno v: Heart. 68:167-170

Objective —To examine the induction of antistreptokinase antibodies after giving streptokinase or anistreplase to patients with acute myocardial infarction. Design —Patients were randomly allocated to receive either 1·5 × 10 6 IU, streptokinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8181c1f19acdbc177eb15afe2f49d7
https://doi.org/10.1136/hrt.68.8.167

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A dose-ranging study of UK-68,798, a novel class III anti-arrhythmic agent, in normal volunteers

Autor: H. S. Rasmussen, W.S. Hillis, Andrew W. Kelman, PA Meredith, HL Elliott, J. D. Gemmill, C. A. Howie

Publikováno v: British Journal of Clinical Pharmacology. 32:429-432

1. UK-68,798, a novel class III anti-arrhythmic agent was administered intravenously to twelve healthy volunteers in a placebo controlled, double-blind, dose-escalating study. 2. Doses of 5 and 10 micrograms kg-1 of UK-68,798 selectively and signific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f3b57f904c3522dcf915eb19e402c9
https://doi.org/10.1111/j.1365-2125.1991.tb03926.x

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A pilot study of the efficacy and safety of bolus administration of alteplase in acute myocardial infarction

Autor: N Booth, P D MacIntyre, F G Dunn, A P Rae, Karen Hogg, W S Hillis, J D Gemmill

Publikováno v: Heart. 66:134-138

OBJECTIVE--To examine the efficacy, safety, and the pharmacokinetic profile of a bolus dose administration regimen of alteplase in the treatment of acute myocardial infarction. DESIGN--An open pilot study. SETTING--District general hospital. PATIENTS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db1498d403116193f4c72a91f018b7a
https://doi.org/10.1136/hrt.66.2.134

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Angiographic patency study of anistreplase versus streptokinase in acute myocardial infarction

Autor: J D Gemmill, K J Hogg, A.P. Rae, W.S. Hillis, W.K. Lifson, J.M.A. Burns, F G Dunn

Publikováno v: The Lancet. 335:254-258

128 patients with acute myocardial infarction of duration 6 h or less were randomised in double-blind fashion to receive 30 U anistreplase over 5 min or 1·5 MU streptokinase over 1 h, both intravenously. Angiographic patency was assessed 90 min and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c149a5b99b9ef92c764c86635b125c0
https://doi.org/10.1016/0140-6736(90)90069-h

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Pre-dosing antibody levels and efficacy of thrombolytic drugs containing streptokinase

Autor: J D Gemmill, F G Dunn, W S Hillis, A P Rae, Karen Hogg

Publikováno v: British heart journal. 72(3)

OBJECTIVE--To evaluate the influence of pretreatment streptokinase resistance titre and the concentration of IgG antibodies to streptokinase on the efficacy of thrombolytic drugs containing streptokinase in restoring coronary patency in acute myocard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5e10fe6d49d264c3a701eb7f0261f1
https://pubmed.ncbi.nlm.nih.gov/7946770

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Assessment by general practitioners of suitability of thrombolysis in patients with suspected acute myocardial infarction

Autor: W.K. Lifson, J D Gemmill, W S Hillis, A P Rae, F G Dunn

OBJECTIVE--To assess the clinical ability of general practitioners to decide to give thrombolytic therapy to patients with suspected myocardial infarction and to assess the contribution of the electrocardiograph (ECG) to this decision-making process.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c16b6bf87b0ed0eba3a3bb1b0d8a525
https://europepmc.org/articles/PMC1025379/

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Transpulmonary pharmacokinetics of an ACE inhibitor (perindoprilat) in man

Autor: JL Reid, Robert J. MacFadyen, J. D. Gemmill, WS Hillis, Kennedy R. Lees

Publikováno v: British journal of clinical pharmacology. 32(2)

1. The transpulmonary pharmacokinetics of the intravenous diacid ACE inhibitor perindoprilat were studied in 10 male patients undergoing diagnostic cardiac catheterisation for the management of ischaemic heart disease. 2. Following successful complet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c0af543929ca0a2c03d5dbeccda398
https://pubmed.ncbi.nlm.nih.gov/1657093

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