Zobrazeno 1 - 10
of 37
pro vyhledávání: '"J. D. Fondacaro"'
Publikováno v:
Journal of Pharmacological Methods. 24:59-71
Evaluation of antisecretory antidiarrheal agents in animal models is limited primarily to extrapolations of efficacy from enteropooling studies in vivo, isolated intestinal loops in situ, and Ussing flux chamber preparations in vitro. While these sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b89ea5df2811867afe23b37a781d8d1c
https://doi.org/10.1016/0160-5402(90)90050-u
https://doi.org/10.1016/0160-5402(90)90050-u
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 258:G329-G337
Increased fecal pellet output that occurs during cold-restraint stress (CRS) was evaluated systematically. Free-feeding rats, which exhibit a reduced occurrence of gastric ulcers under these conditions, were studied. CRS significantly increased fecal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35566a50f892d8c7d55f7f3e1d12334c
https://doi.org/10.1152/ajpgi.1990.258.3.g329
https://doi.org/10.1152/ajpgi.1990.258.3.g329
Publikováno v:
Inflammation. 21(2)
This study investigated metabolic and biochemical consequences of colonic ischemia/reperfusion (I/R) in the rat and evaluated whether antioxidants prevent I/R-induced functional damage in the rat colon. The surgical preparation involved a 10 cm segme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e6d1e3c47f29dd64171f0c66e9220c8
https://pubmed.ncbi.nlm.nih.gov/9187961
https://pubmed.ncbi.nlm.nih.gov/9187961
Publikováno v:
The American journal of physiology. 271(6 Pt 1)
We previously described a model of intestinal hypersensitivity in which isolated gut segments from sensitized rats demonstrated a rapid epithelial secretory response to luminal antigen that was mediated by mucosal mast cells and capsaicin-sensitive n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ee1d52c2232935e1bf7f4a2c17c737
https://pubmed.ncbi.nlm.nih.gov/8997242
https://pubmed.ncbi.nlm.nih.gov/8997242
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 257(2)
Serosal but not mucosal addition of the peptidoleukotrienes, leukotriene (LT) C4 (LTC4), LTD4 and LTE4 transiently (maximal response within 2 min) increased short-circuit current (Isc) and transepithelial conductance across stripped rabbit colonic mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86c509cfcb956dbc5318de569a79f07a
https://pubmed.ncbi.nlm.nih.gov/1851834
https://pubmed.ncbi.nlm.nih.gov/1851834
Publikováno v:
Journal of pharmacological methods. 24(1)
Evaluation of antisecretory antidiarrheal agents in animal models is limited primarily to extrapolations of efficacy from enteropooling studies in vivo, isolated intestinal loops in situ, and Ussing flux chamber preparations in vitro. While these sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2dedc1f7caa820e41ad9c0491da7b831
https://pubmed.ncbi.nlm.nih.gov/2214801
https://pubmed.ncbi.nlm.nih.gov/2214801
Publikováno v:
Agents and Actions. 41:C233-C234
We show here that MDL 73404, a water soluble analog of alpha-tocopherol, provides protective and healing effects in dextran sulfate sodium-mediated colitis in mice. MDL 73404, showed significant dose response at all levels of the disease. The maximum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b2656ccfbf8f883176cf5e7ef509f1f
https://doi.org/10.1007/bf01987650
https://doi.org/10.1007/bf01987650
Publikováno v:
Experimental Biology and Medicine. 174:74-78
In this study, we examined the effects of both pharmacologically and mechanically induced increases in intestinal blood flow on intestinal oxygen consumption. Intraarterial infusions of prostacyclin (1-20 ng-kg-1 -min-1) significantly increased both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7267b0490192b213de56243e6f5de1
https://doi.org/10.3181/00379727-174-41706
https://doi.org/10.3181/00379727-174-41706
Autor:
Don E. Griswold, M A Wasserman, Lester W. Schwartz, Philip L. Simon, Daniel Rachmilewitz, J D Fondacaro
Publikováno v:
Gastroenterology. 97:326-337
Colonic inflammation was induced in rats by intracolonic administration of 0.25 ml of 50% ethanol containing 30 mg of trinitrobenzene sulfonic acid (TNB). Control rats were treated with 0.25 ml of 50% ethanol or with 30 mg of TNB in 0.25 ml of saline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4acdb18593b0d60f77807536958a76
https://doi.org/10.1016/0016-5085(89)90068-1
https://doi.org/10.1016/0016-5085(89)90068-1
Autor:
L. S. Henderson, J. D. Fondacaro
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 249:G422-G426
We examined the possibility that the Ca2+-and phospholipid-dependent protein kinase, protein kinase C, may regulate intestinal electrolyte transport. By use of two active phorbol esters, known activators of protein kinase C, we studied the secretory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04abddb779284b2be8ba27fb4a84475a
https://doi.org/10.1152/ajpgi.1985.249.3.g422
https://doi.org/10.1152/ajpgi.1985.249.3.g422