Zobrazeno 1 - 10 of 11 pro vyhledávání: '"J. D. Coombes"'
1
Inhibition of the rate of 14CO2 production from [14C]ethanol in rats given beta-lactam antibiotics with disulfiram-like effects
Autor: R. M. J. Ings, R. G. Turcan, J. D. Coombes, C. M. Macdonald
Publikováno v: Antimicrobial Agents and Chemotherapy. 27:535-540
An animal model has been developed to investigate the potentials of various beta-lactam antibiotics for inducing (or producing) disulfiram-like effects. The method, which measures the rate of 14CO2 production in rats after [14C]ethanol administration
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf7b96d542a27e490d3382c341321ee
https://doi.org/10.1128/aac.27.4.535
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2
Growth of Trypanosoma cruzi in Human Heart Tissue Cells and Effects of Aminonucleoside of Puromycin, Trypacidin and Aminopterin
Autor: W. E. Gutteridge, J. D. Coombes, J. Knowler
Publikováno v: The Journal of Protozoology. 16:521-525
SYNOPSIS. Development of a suitable tissue cell system for the growth of T. cruzi required the production of infective metacyclic trypanosomes and tissues which these forms could infect. Human heart was selected from a range of serially-cultured tiss
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d899bcc494c7b3a72d69e0aa47a9492
https://doi.org/10.1111/j.1550-7408.1969.tb02311.x
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6
Metabolism of cefotaxime: a review
Autor: H B, Lassman, J D, Coombes
Publikováno v: Diagnostic microbiology and infectious disease. 2
Cefotaxime (CTX) sodium is a potent semisynthetic cephalosporin antibiotic that has an unusually broad spectrum of antibacterial activity. This paper discusses the metabolism of 14C-CTX in rats, dogs, and humans as well as in vitro studies in cells o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7057f9895179591343a93c3fe316fd3e
https://pubmed.ncbi.nlm.nih.gov/6086216
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7
Whole body autoradiographic and quantitative tissue distribution studies with 14C-cefotaxime in the rat
Autor: L A, Stevens, R M, Ings, J M, Fromson, J D, Coombes
Publikováno v: Arzneimittel-Forschung. 34(12)
The absorption, distribution and elimination of radioactivity following intravenous (i.v.) or intramuscular (i.m.) administration of 14C-cefotaxime (14C-HR 756) to the rat has been examined by qualitative and quantitative techniques. After i.v. and i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8798fc4086e4bd90f38e3a8982a04c02
https://pubmed.ncbi.nlm.nih.gov/6099126
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8
Disposition of cefotaxime in rat, dog and man
Autor: C M, Macdonald, J M, Fromson, A, McDonald, D, Dell, J, Chamberlain, J D, Coombes
Publikováno v: Arzneimittel-Forschung. 34(12)
The excretory pathway for the elimination of 14C-cefotaxime (14C-HR 756) was found to be the same for rat, dog and man with elimination into the urine being the most important route, accounting for greater than 80% of the dosed radioactivity. The amo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42d6c6ef2690b6dd5b88662e47625a6c
https://pubmed.ncbi.nlm.nih.gov/6099125
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9
Cefotaxime: sites and pathway of metabolic conversion
Autor: C M, Macdonald, A, McDonald, J M, Fromson, J D, Coombes
Publikováno v: Arzneimittel-Forschung. 34(12)
This paper examines the metabolism of 14C-cefotaxime (14C-HR 756) in the rat and attempts to identify the metabolic events in this and other species. In rat desacetyl cefotaxime is usually the major excretion product and sole metabolite of cefotaxime
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b11aaa142d80ef9cd00e33e721417ce9
https://pubmed.ncbi.nlm.nih.gov/6099127
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