Výsledky vyhledávání - "J. D. Amirkhanian"

Characterization of Surfactant Subtypes of Beractant and a Synthetic Peptide Containing Surfactant KL4 following Surface Area Cycling and Addition of Fibrinogen

Autor: T. A. Merritt, J. D. Amirkhanian, E Manalo, A Kheiter

Publikováno v: Lung. 175:225-233

Surfactant is not a homogeneous material and can be separated into subtypes. Subtype conversion is clinically important because it is thought to occur naturally and because surface activity varies depending on the subtype. Fibrinogen, a naturally occ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fdc59f9d1091935e58981e5f4cada3
https://doi.org/10.1007/pl00007569

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Comparative Effects of Some Serum Components and Proteolytic Products of Fibrinogen on Surface Tension-Lowering Abilities of Beractant and a Synthetic Peptide Containing Surfactant KL41

Autor: J. D. Amirkhanian, T. A. Merritt, Charles G. Cochrane, A Kheiter, E Manalo

Publikováno v: Pediatric Research. 39:947-952

The serum components of C-reactive protein, lysophosphatidylcholine, fibrinogen, and fibrinogen proteolytic products have been shown to reduce surface tension-lowering abilities of lung surfactant. The inhibitory effects of these serum components wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33b4e25db16a28bba804f4454e3f69cf
https://doi.org/10.1203/00006450-199606000-00004

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Reduction of the surface-tension-lowering ability of surfactant after exposure to hypochlorous acid

Autor: T. A. Merritt, Barry Halliwell, J. D. Amirkhanian, Carroll E. Cross, H. Helbock

Publikováno v: Biochemical Journal. 295:19-22

The reactive species hypochlorous acid (HOCl/OCl-) is a major product of the respiratory burst in activated neutrophils. We studied the effects of HOCl/OCl- on human surfactant and upon surfactants Survanta, KL4 and Exosurf, utilizing a pulsating sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4530e2fb3ab7733b1897d6e4d0276f7e
https://doi.org/10.1042/bj2950019

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Inhibitory effects of oxyradicals on surfactant function: utilizing in vitro Fenton reaction

Autor: T. A. Merritt, J. D. Amirkhanian

Publikováno v: Lung. 176(1)

The inhibitory effects of reactive oxygen species (ROS) on the surface tension-lowering abilities of three surfactants were compared: natural lung surfactant (NLS), KL4 surfactant containing synthetic peptide resembling the hydrophobic/hydrophilic do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672ad8751a64b4748bd6940d6cc2e6c1
https://pubmed.ncbi.nlm.nih.gov/9436178

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Combined effects of nitric oxide and hyperoxia on surfactant function and pulmonary inflammation

Autor: F. C. Morin, J. D. Amirkhanian, Namita Sahgal, Jonathan M. Davis, Carolyn G. Robbins, Stuart Horowitz, T. A. Merritt

Publikováno v: The American journal of physiology. 269(4 Pt 1)

NO and its derivative ONOO- are potent free radicals that can cause cell damage, especially in the presence of O 2 . To determine the potential pulmonary toxicities of nitric oxide (NO) and peroxynitrite (ONOO-) in vitro, Survanta (2.5 mg/ml) was exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0a4b17a9bda7d5233b8d5309682aed
https://pubmed.ncbi.nlm.nih.gov/7485528

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The influence of pH on surface properties of lung surfactants

Autor: T. A. Merritt, J. D. Amirkhanian

Publikováno v: Lung. 173(4)

Protein-lipid interactions at air-liquid interfaces are dependent on electrostatic charges, cations, anions, distribution of protons, and surface potential, which are influenced by pH changes. All of these factors may affect lung surfactant function.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfab9f492a5b034db1658fc9bd29e1a2
https://pubmed.ncbi.nlm.nih.gov/7564483

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Reversible and irreversible inactivation of preformed pulmonary surfactant surface films by changes in subphase constituents

Autor: H W Taeusch, J D Amirkhanian

Publikováno v: Biochimica et biophysica acta. 1165(3)

Several mechanisms for surfactant inactivation have been reported. In this study, we have measured the reversibility of surfactant inactivation caused by various lipid or protein constituents of plasma or by pH changes. A surfactant of bovine origin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d54fdd2f6f8e14c0a004c138e65880
https://pubmed.ncbi.nlm.nih.gov/8418890

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A Combined Hcl-Acetic-Alcohol Fixation and Hydrolysis Followed by Cresyl Violet Staining for Mosquito Chromosome Spreads

Autor: J. D. Amirkhanian

Publikováno v: Stain Technology. 43:167-170

Mosquito tissues of cytogenetical importance were dissected out on a slide in 0.65% NaCl, under a dissecting microscope, and treated about 30 sec in a drop of 1:3 Carnoy's fixative diluted 1:19 with distilled water. Fixing and hydrolysis was done by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7406215b439767ee4bd0ef9ff1315d1f
https://doi.org/10.3109/10520296809115062

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Genetic characterization of the new morphological and UV-sensitive mutants inCoprinus cinereus. I. A UV-sensitive mutationrad1 associated with elevated frequencies of mitotic and meiotic recombination

Autor: J. D. Amirkhanian

Publikováno v: Experientia. 35:1017-1019

Studies on the effect of an UV-sensitive mutation, rad 1, in meiotic and mitotic recombination in Coprinus indicated that, in homozygous condition, rad 1 increased the spontaneous meiotic recombination by 50% and UV-induced mitotic intergenic recombi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4861887016d5d0e9bcc99339c5b20a0
https://doi.org/10.1007/bf01949915

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