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Akademický článek

Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice

Autor: Melissa R. Pergande, Christina Kang, Diann George, Pearl A. Sutter, Stephen J. Crocker, Stephanie M. Cologna, Maria I. Givogri

Publikováno v: Lipids in Health and Disease, Vol 21, Iss 1, Pp 1-19 (2022)

Abstract Background Recent findings show that extracellular vesicle constituents can exert short- and long-range biological effects on neighboring cells in the brain, opening an exciting avenue for investigation in the field of neurodegenerative dise

Externí odkaz: https://doaj.org/article/81ba21c6879f47b39112097282b4e604

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Akademický článek

The Cellular Senescence Factor Extracellular HMGB1 Directly Inhibits Oligodendrocyte Progenitor Cell Differentiation and Impairs CNS Remyelination

Autor: Megan E. Rouillard, Jingwen Hu, Pearl A. Sutter, Hee Won Kim, Jeffrey K. Huang, Stephen J. Crocker

Publikováno v: Frontiers in Cellular Neuroscience, Vol 16 (2022)

HMGB1 is a highly conserved, ubiquitous protein in eukaryotic cells. HMGB1 is normally localized to the nucleus, where it acts as a chromatin associated non-histone binding protein. In contrast, extracellular HMGB1 is an alarmin released by stressed

Externí odkaz: https://doaj.org/article/a4963e36f09b4cdaba664da72e4c6273

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Akademický článek

The Pathogenic Sphingolipid Psychosine is Secreted in Extracellular Vesicles in the Brain of a Mouse Model of Krabbe Disease

Autor: Cory R. Reiter, Rima Rebiai, Angelika Kwak, Jeff Marshall, Dylan Wozniak, Giusepe Scesa, Duc Nguyen, Emily Rue, Koralege C. Pathmasiri, Robert Pijewski, Richard van Breemen, Stephanie Cologna, Stephen J. Crocker, M Irene Givogri, Ernesto R Bongarzone

Publikováno v: ASN Neuro, Vol 14 (2022)

Psychosine exerts most of its toxic effects by altering membrane dynamics with increased shedding of extracellular vesicles (EVs). In this study, we discovered that a fraction of psychosine produced in the brain of the Twitcher mouse, a model for Kra

Externí odkaz: https://doaj.org/article/4a45a69642534fae9ba02c13cb43e826

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Akademický článek

Studying alcohol use disorder using Drosophila melanogaster in the era of ‘Big Data’

Autor: Gregory L. Engel, Kreager Taber, Elizabeth Vinton, Amanda J. Crocker

Publikováno v: Behavioral and Brain Functions, Vol 15, Iss 1, Pp 1-16 (2019)

Abstract Our understanding of the networks of genes and protein functions involved in Alcohol Use Disorder (AUD) remains incomplete, as do the mechanisms by which these networks lead to AUD phenotypes. The fruit fly (Drosophila melanogaster) is an ef

Externí odkaz: https://doaj.org/article/c0594911b68b46898df75c5f7a49e237

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Akademický článek

Stem Cells of the Aging Brain

Autor: Alexandra M. Nicaise, Cory M. Willis, Stephen J. Crocker, Stefano Pluchino

Publikováno v: Frontiers in Aging Neuroscience, Vol 12 (2020)

The adult central nervous system (CNS) contains resident stem cells within specific niches that maintain a self-renewal and proliferative capacity to generate new neurons, astrocytes, and oligodendrocytes throughout adulthood. Physiological aging is

Externí odkaz: https://doaj.org/article/3017e2438b234c0398950eb96096d84f

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Late Miocene cooling coupled to carbon dioxide with Pleistocene-like climate sensitivity

Autor: Rachel M. Brown, Thomas B. Chalk, Anya J. Crocker, Paul A. Wilson, Gavin L. Foster

Publikováno v: Nature Geoscience
Nature Geoscience, 2022, 15, pp.664-670. ⟨10.1038/s41561-022-00982-7⟩

International audience; Earth's climate cooled markedly during the late Miocene from 12 to 5 million years ago, with far-reaching consequences for global ecosystems. However, the driving forces of these changes remain controversial. A major obstacle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b050f34d3ba24fda9d9f86a942be724
https://doi.org/10.1038/s41561-022-00982-7

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Akademický článek

TIMP-1 Attenuates the Development of Inflammatory Pain Through MMP-Dependent and Receptor-Mediated Cell Signaling Mechanisms

Autor: Brittany E. Knight, Nathan Kozlowski, Joshua Havelin, Tamara King, Stephen J. Crocker, Erin E. Young, Kyle M. Baumbauer

Publikováno v: Frontiers in Molecular Neuroscience, Vol 12 (2019)

Unresolved inflammation is a significant predictor for developing chronic pain, and targeting the mechanisms underlying inflammation offers opportunities for therapeutic intervention. During inflammation, matrix metalloproteinase (MMP) activity contr

Externí odkaz: https://doaj.org/article/3bd28f11e90e4c17bf2998e03d1e4be8

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