Zobrazeno 1 - 10
of 23
pro vyhledávání: '"J. Cristian Salgado"'
Autor:
Natalia E. Jiménez, Ziomara P. Gerdtzen, Álvaro Olivera-Nappa, J. Cristian Salgado, Carlos Conca
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Arboviral diseases such as Zika and Dengue have been on the rise mainly due to climate change, and the development of new treatments and strategies to limit their spreading is needed. The use of Wolbachia
Externí odkaz:
https://doaj.org/article/616832e224c947da89d42f97cf3881b8
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1791-C1806
Iron absorption is a complex and highly controlled process where DMT1 transports nonheme iron through the brush-border membrane of enterocytes to the cytoplasm but does not transport alkaline-earth metals such as calcium. However, it has been propose
Autor:
J. Cristian Salgado, Ziomara P. Gerdtzen, Álvaro Olivera-Nappa, Carlos Conca, Natalia E Jiménez
Publikováno v:
mBio
mBio, Vol 12, Iss 5 (2021)
mBio, Vol 12, Iss 5 (2021)
Wolbachia are endosymbiont bacteria known to infect arthropods causing different effects, such as cytoplasmic incompatibility and pathogen blocking in Aedes aegypti. Although several Wolbachia strains have been studied, there is little knowledge rega
Publikováno v:
Journal of Cleaner Production. 133:99-116
A variety of indicators is available for assessing the economic, environmental, and social aspects of an Eco-industrial park (EIP). The managers of a sustainability assessment over these parks should overcome an important task at the beginning of the
Autor:
Ziomara P. Gerdtzen, Marco T. Núñez, Álvaro Olivera-Nappa, J. Cristian Salgado, Andrés Esparza
Publikováno v:
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
CONICYT Chile
instacron:CONICYT
Recent evidence shows that iron induces the endocytosis of the iron transporter dimetal transporter 1 (DMT1) during intestinal absorption. We, and others, have proposed that iron-induced DMT1 internalization underlies the mucosal block phenomena, a r
Revealing Monoamine Oxidase B Catalytic Mechanisms by Means of the Quantum Chemical Cluster Approach
Autor:
Cristian Celis-Barros, Gerald Zapata-Torres, Angélica Fierro, J. Cristian Salgado, Germán Barriga-González
Publikováno v:
Journal of Chemical Information and Modeling. 55:1349-1360
Two of the possible catalytic mechanisms for neurotransmitter oxidative deamination by monoamine oxidase B (MAO B), namely, polar nucleophilic and hydride transfer, were addressed in order to comprehend the nature of their rate-determining step. The
Molecular dynamics simulation of halogen bonding mimics experimental data for cathepsin L inhibition
Autor:
Leslie Saavedra-Rivas, Bruce K. Cassels, Cristian Celis-Barros, J. Cristian Salgado, Gerald Zapata-Torres
Publikováno v:
Journal of Computer-Aided Molecular Design. 29:37-46
A MD simulation protocol was developed to model halogen bonding in protein-ligand complexes by inclusion of a charged extra point to represent the anisotropic distribution of charge on the halogen atom. This protocol was then used to simulate the int
Publikováno v:
Colins, A, Gerdtzen, Z P, Nuñez, M T & Salgado, J C 2017, ' Mathematical modeling of intestinal iron absorption using genetic programming ', PLoS ONE . https://doi.org/10.1371/journal.pone.0169601
PLoS ONE, Vol 12, Iss 1, p e0169601 (2017)
PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0169601 (2017)
PLoS ONE
Iron is a trace metal, key for the development of living organisms. Its absorption process is complex and highly regulated at the transcriptional, translational and systemic levels. Recently, the internalization of the DMT1 transporter has been propo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e04a39c2e77e68c7b260ff5eaf27598
https://doi.org/10.1371/journal.pone.0169601
https://doi.org/10.1371/journal.pone.0169601
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218123 (2019)
PLoS ONE
PLoS ONE
Iron is essential for the normal development of cellular processes. This metal has a high redox potential that can damage cells and its overload or deficiency is related to several diseases, therefore it is crucial for its absorption to be highly reg
Autor:
Angélica Fierro, Gerald Zapata-Torres, J. Cristian Salgado, Cristian Celis-Barros, Carlos Guajardo, Sebastián Miranda-Rojas, Patricio Sáez-Briones
Publikováno v:
JOURNAL OF CHEMICAL INFORMATION AND MODELING
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Although substrate conversion mediated by human monoaminooxidase (hMAO) has been associated with the deprotonated state of their amine moiety, data regarding the influence of protonation on substrate binding at the active site are scarce. Thus, in or