Zobrazeno 1 - 10
of 23
pro vyhledávání: '"J. Craig Hartman"'
Autor:
Steve R. Roof, Yukie Ueyama, Reza Mazhari, Robert L. Hamlin, J. Craig Hartman, Mark T. Ziolo, John E. Reardon, Carlos L. del Rio
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
The nitroxyl (HNO) prodrug, CXL-1020, induces vasorelaxation and improves cardiac function in canine models and patients with systolic heart failure (HF). HNO's unique mechanism of action may be applicable to a broader subset of cardiac patients. Thi
Externí odkaz:
https://doaj.org/article/3b8b471a543e49efbf76a4770d5c30ff
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Nitroxyl (HNO) enhances SR calcium uptake and release in cardiomyocytes, and improves myofilament calcium sensitivity without impacting L-type calcium channel or total SR calcium content. • The effects of the nit
Highlights • Nitroxyl (HNO) enhances SR calcium uptake and release in cardiomyocytes, and improves myofilament calcium sensitivity without impacting L-type calcium channel or total SR calcium content. • The effects of the nit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803069b3001ba958ec9683326d90c4ae
https://doi.org/10.1016/j.jacbts.2018.07.003
https://doi.org/10.1016/j.jacbts.2018.07.003
Autor:
Mark T. Ziolo, Steve R. Roof, John Reardon, J. Craig Hartman, Carlos del Rio, Robert L. Hamlin, Reza Mazhari, Yukie Ueyama
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 8 (2017)
Frontiers in Physiology, Vol 8 (2017)
The nitroxyl (HNO) prodrug, CXL-1020, induces vasorelaxation and improves cardiac function in canine models and patients with systolic heart failure (HF). HNO's unique mechanism of action may be applicable to a broader subset of cardiac patients. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d7a050b9140ae4d80688637b5cbe6f
http://europepmc.org/articles/PMC5701606
http://europepmc.org/articles/PMC5701606
Autor:
John A. Schriefer, J Craig Hartman
Publikováno v:
Expert Opinion on Investigational Drugs. 5:1465-1476
Bradykinin (BK) is a widely distributed nine amino acid peptide with potent cardiovascular effects. Physiologically, BK has a very brief duration of action due to rapid metabolism by a number of widely distributed enzymes, including carboxypeptidase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f30610dd9dd799ec229024c341701cf
https://doi.org/10.1517/13543784.5.11.1465
https://doi.org/10.1517/13543784.5.11.1465
Autor:
William R. Humphrey, Caryl L. Lane, Donald C. Anderson, Theron M. Wall, Ronald J. Shebuski, J. Craig Hartman, Ann L. Wiltse, Anthony M. Manning, Craig L. Rosenbloom
Publikováno v:
Cardiovascular Research. 30:47-54
Objective: A blocking monoclonal antibody to intercellular adhesion molecule-1 (ICAM-1), CL18/6, previously has been demonstrated to inhibit neutrophil attachment to isolated vascular endothelium and cardiomyocytes. Due to the well known participatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::755d92ac596f7da18ae272d66eeedfdf
https://doi.org/10.1016/s0008-6363(95)00015-1
https://doi.org/10.1016/s0008-6363(95)00015-1
Autor:
Ronald J. Shebuski, Rita M. Sheehy, Ann L. Wiltse, J. Craig Hartman, Colin J. Dunn, James P. McGrath
Publikováno v:
Drug Delivery. 2:190-197
The objective of this investigation was to examine the ability of two diphosphonate compounds, ethylenediaminetetraacetic acid (EDTA), and D-mannitol to specifically target ischemic/infarcted myocardium. Dichloromethylenephosphonic tetraester or tetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec5bc0a6e2020e1927ca7e9528284046
https://doi.org/10.3109/10717549509031369
https://doi.org/10.3109/10717549509031369
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 31:153-160
The objective of this investigation was to validate a transit-time ultrasound blood flow metering system in vivo. Implanted chronically and acutely on the ascending aorta of the dog, the transit-time flow probe determined varying flow rates simultane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494b255069b8e41626dd816220fae7b6
https://doi.org/10.1016/1056-8719(94)90078-7
https://doi.org/10.1016/1056-8719(94)90078-7
Autor:
Kyle Wagner, Clifford D. Wright, Kristin M. Joly, J. Craig Hartman, Craig F. Plato, John T. Liles
Publikováno v:
D39. NOVEL THERAPEUTICS IN PULMONARY FIBROSIS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ecb5dc15e3b0a8977a7d4bf7ff7051a
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6042
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6042
Publikováno v:
European Journal of Pharmacology. 234:229-236
The angiotensin-converting enzyme inhibitor ramiprilat, the angiotensin II receptor antagonist losartan, angiotensin II, ramiprilat plus angiotensin II, or saline (N = 6 each group), were administered i.v. in anesthetized, open-chest rabbit preparati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2bd22a09ec8c73c4031a70c40a428c6
https://doi.org/10.1016/0014-2999(93)90958-k
https://doi.org/10.1016/0014-2999(93)90958-k
Autor:
Faquan, Liang, Christopher B, Glascock, Denise L, Schafer, Jennifer, Sandoval, LouAnn, Cable, Lawrence, Melvin, J Craig, Hartman, Kelly R, Pitts
Publikováno v:
Canadian journal of physiology and pharmacology. 88(8)
Endothelin is a potent vasoconstrictor often up-regulated in hypertension. Endothelin vasoconstriction is mediated via the G-protein coupled endothelin A (ETA) receptor present on vascular smooth muscle. Endothelin receptor antagonists (ERAs) have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b912a8a0faee6e49bd89114bf37edb9f
https://pubmed.ncbi.nlm.nih.gov/20725142
https://pubmed.ncbi.nlm.nih.gov/20725142