Zobrazeno 1 - 10
of 525
pro vyhledávání: '"J. Cossette"'
Autor:
Sean H. Kelly, Nicole L. Votaw, Benjamin J. Cossette, Yaoying Wu, Shamitha Shetty, Lucas S. Shores, Luqman A. Issah, Joel H. Collier
Publikováno v:
Science Advances. 8
Urinary tract infections (UTIs) are a major public health problem affecting millions of individuals each year. Recurrent UTIs are managed by long-term antibiotic use, making the alarming rise of antibiotic resistance a substantial threat to future UT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0021db2c15639ff9e35360663faa884b
https://doi.org/10.1126/sciadv.abq4120
https://doi.org/10.1126/sciadv.abq4120
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity
Autor:
Wuhbet Abraham, Erik Georgeson, Kangsan Roh, Jason Y. Chang, Shuhao Xiao, Daniel Lingwood, Brittany L. Hartwell, Ivy Phung, Bettina Groschel, Diane G Carnathan, Ayush Thomas, Kimberly M. Cirelli, Darrell J. Irvine, Murillo Silva, Li Zhongming, Galit Alter, Guido Silvestri, Jan Willem Maurits van Wijnbergen, Jinal Bhiman, Caitlyn Linde, Yu Kato, Timothy P. Padera, Raiza Bastidas, Hannah C. Watkins, William R. Schief, Sonya Haupt, Swati Kataria, Julia Bals, Dennis R. Burton, Ruth M. Ruprecht, Shane Crotty, Nicole Phelps, Kristen A Rodrigues, Mariane B. Melo, Angela M. Belcher, Brian L. Freeman, Na Li, Benjamin J. Cossette, Aereas Aung, Nathaniel I. Bloom, Chiamaka A. Enemuo
Publikováno v:
Sci Immunol
Saponins are potent and safe vaccine adjuvants, but their mechanisms of action remain incompletely understood. Here, we explored the properties of several saponin formulations, including immunostimulatory complexes (ISCOMs) formed by the self-assembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97d19fd8aafb20e222dae6d4f635287
https://doi.org/10.1126/sciimmunol.abf1152
https://doi.org/10.1126/sciimmunol.abf1152
Publikováno v:
ACS Biomater Sci Eng
Effective sublingual peptide immunization requires overcoming challenges of both delivery and immunogenicity. Mucosal adjuvants, such as cyclic-di-nucleotides (CDN), can promote sublingual immune responses but must be co-delivered with the antigen to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c81aee3be9f82575b6503148c716d974
https://pubmed.ncbi.nlm.nih.gov/33775089
https://pubmed.ncbi.nlm.nih.gov/33775089
Autor:
Diane G. Carnathan, Christopher A. Cottrell, Shane Crotty, Aleksandar Antanasijevic, William R. Schief, George Ueda, David Baker, Jeffrey Copps, Chiamaka A. Enemuo, Kimberly M. Cirelli, Talar Tokatlian, Sergey Menis, Jacob T. Martin, Torben Schiffner, Yury Choe, Neil P. King, Benjamin J. Cossette, Federico Viviano, Guido Silvestri, Etse H. Gebru, Darrell J. Irvine, Andrew B. Ward
Following immunization, high affinity antibody responses develop within germinal centers (GCs), specialized sites within follicles of the lymph node (LN) where B cells proliferate and undergo somatic hypermutation. Antigen availability within GCs is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6db4cb6c23f08bb7cc5dde040647509
https://doi.org/10.1101/2020.02.19.956482
https://doi.org/10.1101/2020.02.19.956482
Autor:
Darrell J. Irvine, Torben Schiffner, Josetta Adams, Talar Tokatlian, Wei Zhang, Mariane B. Melo, William R. Schief, Crystal G. Franklin, Siqi Gong, Brittany L. Hartwell, Diane G. Carnathan, Ruth M. Ruprecht, Benjamin J. Cossette, Sergey Menis, Sidath C. Kumarapperuma, Guido Silvestri, Jacob T. Martin, Peter T. Fox, Beth Goins
Publikováno v:
Biomaterials
Elsevier
Elsevier
Antigen accumulation in lymph nodes (LNs) is critical for vaccine efficacy, but understanding of vaccine biodistribution in humans or large animals remains limited. Using the rhesus macaque model, we employed a combination of positron emission tomogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5c95baa91a5256fd8a0edfed9720ab
https://doi.org/10.1016/j.biomaterials.2021.120868
https://doi.org/10.1016/j.biomaterials.2021.120868
Autor:
Talar Tokatlian, Torben Schiffner, Etse H. Gebru, Benjamin J. Cossette, Neil P. King, David Baker, Federico Viviano, Guido Silvestri, Diane G. Carnathan, Jacob T. Martin, Yury Choe, George Ueda, Stephanie Fischinger, Andrew B. Ward, Aleksandar Antanasijevic, Galit Alter, Kimberly M. Cirelli, Chiamaka A. Enemuo, William R. Schief, Shane Crotty, Jeffrey Copps, Sergey Menis, Christopher A. Cottrell, Darrell J. Irvine
Publikováno v:
NPJ Vaccines
npj Vaccines, Vol 5, Iss 1, Pp 1-15 (2020)
npj Vaccines, Vol 5, Iss 1, Pp 1-15 (2020)
Following immunization, high-affinity antibody responses develop within germinal centers (GCs), specialized sites within follicles of the lymph node (LN) where B cells proliferate and undergo somatic hypermutation. Antigen availability within GCs is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15decb9cdf14c9fa5f3970f60c27e90
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85089019947
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85089019947
Autor:
Wuhbet Abraham, Naveen K. Mehta, Murillo Silva, Simon Liang, Jason Y. Chang, Michael Fichter, Darrell J. Irvine, Nikki Thai, Leyuan Ma, K. Dane Wittrup, Benjamin J. Cossette, Chensu Wang, Tanmay Dichwalkar, Daniel Garafola, Na Li, Sudha Kumari, Angela Q. Zhang
Chimeric antigen receptor-T cell (CAR-T) therapy has been effective in the treatment of hematologic malignancies, but it has shown limited efficacy against solid tumors. Here we demonstrate an approach to enhancing CAR-T function in solid tumors by d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4527c395376aa061e41dfa8ec52998d0
https://europepmc.org/articles/PMC6800571/
https://europepmc.org/articles/PMC6800571/
Autor:
Lange Ferreira, Christina1,2 (AUTHOR) Christina.Lange_Ferreira@kcl.ac.uk, Donetto, Sara3 (AUTHOR), Habte-Asres, Hellena1 (AUTHOR), Govindan, Jyothish2 (AUTHOR), Forbes, Angus1 (AUTHOR), Winkley, Kirsty1 (AUTHOR)
Publikováno v:
PLoS ONE. 12/12/2024, Vol. 19 Issue 12, p1-17. 17p.
Publikováno v:
Diabetologia. 45:642-650
Recent studies involving electrophysiology and immunolabelling indicate that short-term insulin treatment of hippocampal neurons in culture induces changes in glutamate receptor function, suggesting that this receptor system can be altered on a relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9ff760eab281b2bfff45e7341a6fda
https://doi.org/10.1007/s00125-002-0818-5
https://doi.org/10.1007/s00125-002-0818-5
Autor:
Roe EF; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA., Freire Haddad H; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA., Lazar KM; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA., Liu P; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA., Collier JH; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.
Publikováno v:
Advanced healthcare materials [Adv Healthc Mater] 2024 Dec 15, pp. e2402055. Date of Electronic Publication: 2024 Dec 15.