Zobrazeno 1 - 10
of 268
pro vyhledávání: '"J. Coppey"'
Publikováno v:
Physiological Reports, Vol 6, Iss 15, Pp n/a-n/a (2018)
Abstract We tested whether dietary fatty acids alter membrane composition shifting localization of signaling pathways within caveolae to determine their role in vascular function. Wild type (WT) and caveolin‐1‐deficient mice (cav‐1 KO), require
Externí odkaz:
https://doaj.org/article/6768824a6028428a91045f960638d587
Publikováno v:
Journal of Diabetes Research, Vol 2018 (2018)
In this study, we wanted to extend our investigation of the efficacy of fish oil with or without salsalate on vascular and neural complications using a type 2 diabetic rat model. Four weeks after the onset of hyperglycemia, diabetic rats were treated
Externí odkaz:
https://doaj.org/article/7d5ed42bd3cf4cc18a18194093b192eb
Autor:
Matthew S. Yorek, Lawrence J. Coppey, Hanna Shevalye, Alexander Obrosov, Randy H. Kardon, Mark A. Yorek
Publikováno v:
Journal of Nutrition and Metabolism, Vol 2016 (2016)
Aims. In this study a streptozotocin induced type 1 diabetes mouse model was used to assess the effectiveness of salsalate, menhaden oil, the combination of salsalate and menhaden oil, or resolvin D1 on neuropathic endpoints. Materials and Methods. C
Externí odkaz:
https://doaj.org/article/4fc28f0ebb4f4cca9690fc92f5d9429c
Publikováno v:
Journal of Diabetes Research, Vol 2015 (2015)
We examined whether reversal of high fat diet, stimulating weight loss, compared to two treatments previously shown to have beneficial effects, could improve glucose utilization and peripheral neuropathy in animal models of obesity and type 2 diabete
Externí odkaz:
https://doaj.org/article/975c39fda5f44940912c64e8c303f6c0
Autor:
Eric P. Davidson, Lawrence J. Coppey, Amey Holmes, Sergey Lupachyk, Brian L. Dake, Christine L. Oltman, Richard G. Peterson, Mark A. Yorek
Publikováno v:
Journal of Diabetes Research, Vol 2014 (2014)
Recently a new rat model for type 2 diabetes the Zucker diabetic Sprague-Dawley (ZDSD/Pco) was created. In this study we sought to characterize the development of diabetic neuropathy in ZDSD rats using age-matched Sprague-Dawley rats as a control. Ra
Externí odkaz:
https://doaj.org/article/1ecf2629e59b4ff0af1f668cc1bc67fe
Autor:
Mark A. Yorek, Brian D. Fink, Robert J. Kerns, Liping Yu, Alexander Obrosov, William I. Sivitz, Hanna Shevalye, Lawrence J. Coppey
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 1, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives, Vol 9, Iss 1, Pp n/a-n/a (2021)
Previous work by ourselves and others showed that mitoquinone (mitoQ) reduced oxidative damage and prevented hepatic fat accumulation in mice made obese with high‐fat (HF) feeding. Here we extended these studies to examine the effect of mitoQ on pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81dfef801dd55d3f8c56fdfa54c0574
https://doi.org/10.1002/prp2.701
https://doi.org/10.1002/prp2.701
Autor:
Lawrence J. Coppey, William J. Paradee, Eric P. Davidson, Alexander Obrosov, Mark A. Yorek, Hanna Shevalye
Publikováno v:
Journal of Diabetes Research, Vol 2021 (2021)
Journal of Diabetes Research
Journal of Diabetes Research
To rigorously explore the role of omega-3 polyunsaturated fatty acids (PUFA) in the treatment of diabetic peripheral neuropathy (DPN), we have created a transgenic mouse utilizing a Cre-lox promoter to control overexpression of human 15-lipoxygenase-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aaa72e05acb8357bf2d7cc84c7fe835
https://doaj.org/article/9d6be9e61c6f4010baf31e6f63688de3
https://doaj.org/article/9d6be9e61c6f4010baf31e6f63688de3
Autor:
Lawrence J. Coppey, Alexander Obrosov, Eric P. Davidson, Mark A. Yorek, William I. Sivitz, Pratik Rajesh Chheda, Hanna Shevalye, Robert J. Kerns, Brian D. Fink
Publikováno v:
Free Radic Res
This study sought to determine whether the addition of mitoquinone (Mito-Q) in the diet is an effective treatment for peripheral neuropathy in animal models of diet-induced obesity (pre-diabetes) and type 2 diabetes. Unlike other anti-oxidative stres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7425c5cec4fd2fcaba807ffc85b3fc1
https://europepmc.org/articles/PMC7329571/
https://europepmc.org/articles/PMC7329571/
Publikováno v:
Journal of Nutrition and Metabolism, Vol 2012 (2012)
Aims. To determine the effect of partial replacement of a high-fat diet with menhaden oil on diabetic neuropathy in an animal model of type 2 diabetes. Materials and Methods. High-fat/low-dose streptozotocin diabetic rats were used to examine the inf
Externí odkaz:
https://doaj.org/article/ff26d54f90904d14894f32c161ad4473
Publikováno v:
Journal of Diabetes Research, Vol 2018 (2018)
Journal of Diabetes Research
Journal of Diabetes Research
In this study, we wanted to extend our investigation of the efficacy of fish oil with or without salsalate on vascular and neural complications using a type 2 diabetic rat model. Four weeks after the onset of hyperglycemia, diabetic rats were treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a94748b37d723c2253625504209d8f
https://doi.org/10.1155/2018/2967127
https://doi.org/10.1155/2018/2967127