Zobrazeno 1 - 10
of 44
pro vyhledávání: '"J. Constanze"'
Autor:
Marco Palmieri, Dominik Rufle, Fabrice Gallou, J. Constanze D. Hartwieg, Cara E. Brocklehurst
Publikováno v:
Organic Process Research & Development. 22:1453-1457
A screening method to evaluate Suzuki–Miyaura and Buchwald–Hartwig coupling reactions under aqueous surfactant conditions has been established, leading to high yielding and highly selective Suzuki–Miyaura and Buchwald–Hartwig reactions under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fe6e6e8e66c47ec1346b9dbbf5a0946
https://doi.org/10.1021/acs.oprd.8b00200
https://doi.org/10.1021/acs.oprd.8b00200
Autor:
Andreas Marzinzik, Silvio Ofner, Jean-Michel Rondeau, Wolfgang Jahnke, Chrystelle Henry, S. Lehmann, E. Bourgier, Xavier Pelle, Jonathan Green, J. Constanze D. Hartwieg, Rene Hemmig, Simona Cotesta, Guido Bold, Frédéric Stauffer
Publikováno v:
Angewandte Chemie. 127:14783-14787
Die Wirksamkeit und Vertraglichkeit eines Medikaments kann verbessert werden, indem dieses gezielt an den gewunschten Wirkungsort gebracht wird. Bisphosphonate sind Prototypen derartiger Medikamente; allerdings ist ihre Affinitat zum Knochen eher zu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87792e19609ec7716e6908d3d507899a
https://doi.org/10.1002/ange.201507064
https://doi.org/10.1002/ange.201507064
Autor:
Eric Francotte, Jan W. Priess, Claudio Valente, Dominik Rufle, Christophe Bury, Luigi La Vecchia, Heiner Schütz, J. Constanze D. Hartwieg
Publikováno v:
Organic Process Research & Development. 18:1120-1127
3,5-Disubstituted piperidines are versatile building blocks that find broad application in medicinal chemistry programs. Here we describe how all four diastereoisomers of a 5-aryl-substituted nipec...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48463b49abfc33a24a304cac8dd258b6
https://doi.org/10.1021/op500170d
https://doi.org/10.1021/op500170d
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Claus Ehrhardt, Takatoshi Kosaka, Jörg Trappe, Richard Sedrani, Bernd Gerhartz, Jürgen Maibaum, Simon Ruedisser, Sabine Geisse, Dean F. Rigel, Frederic Cumin, Johannes Ottl, Nils Ostermann, Trixie Wagner, Markus Krömer, Andreas Marzinzik, Eric Vangrevelinghe, Paul Richert, Edgar Jacoby, Martin Klumpp, Daniel K. Baeschlin, Eric Francotte, Randy L. Webb, J. Constanze D. Hartwieg, Werner Breitenstein, Ulrich Hassiepen
Publikováno v:
Journal of Medicinal Chemistry. 56:2196-2206
A small library of fragments comprising putative recognition motifs for the catalytic dyad of aspartic proteases was generated by in silico similarity searches within the corporate compound deck based on rh-renin active site docking and scoring filte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56536415f82cd33ef62b0ef099e5195e
https://doi.org/10.1021/jm301706j
https://doi.org/10.1021/jm301706j
Autor:
Markus Furegati, Cara E. Brocklehurst, Flavio Ossola, Luigi La Vecchia, J. Constanze D. Müller-Hartwieg
Publikováno v:
Helvetica Chimica Acta. 93:314-323
α-Aminomethylation of (R)-DIOZ-alkylated (DIOZ=4-isopropyl-5,5-diphenyloxazolidin-2-one) substrates is a key step in the asymmetric synthesis of β2-amino acids, but it is unfortunately often accompanied by formation of transcarbamation by-products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::919ac571b927b4ecc9eaac9bcd3a254a
https://doi.org/10.1002/hlca.200900401
https://doi.org/10.1002/hlca.200900401
Autor:
Cara E. Humphrey, Thomas Leutert, Markus Furegati, Kurt Laumen, Markus Vögtle, Luigi La Vecchia, J. Constanze D. Müller-Hartwieg
Publikováno v:
Organic Process Research & Development. 11:1069-1075
This paper demonstrates how l-m-tyrosine 1 can be synthesized on larger-scale via enzyme-catalyzed kinetic resolution of N-acyl m-tyrosine methyl ester 4. N-Acyl m-tyrosine methyl ester 4 was prepared by a modification of Erlenmeyer’s azalactone sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30e7d4f30e693748722ddb1d704c305e
https://doi.org/10.1021/op700093y
https://doi.org/10.1021/op700093y
Autor:
Jean-Michel Rondeau, E. Bourgier, Marjo Götte, Johann Zimmermann, Armin Widmer, Steven J. Stout, Andreas Marzinzik, René Amstutz, Wolfgang Jahnke, S. Lehmann, Xavier Pelle, Christelle Henry, Frédéric Stauffer, Silvio Ofner, Simona Cotesta, Guido Bold, Thomas Zoller, J. Fraser Glickman, Thomas P. Roddy, J. Constanze D. Hartwieg
Publikováno v:
ChemMedChem. 10(11)
Farnesyl pyrophosphate synthase (FPPS) is an established target for the treatment of bone diseases, but also shows promise as an anticancer and anti-infective drug target. Currently available anti-FPPS drugs are active-site-directed bisphosphonate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38093a983a2bffe41ce36a8d35f93526
https://pubmed.ncbi.nlm.nih.gov/26381451
https://pubmed.ncbi.nlm.nih.gov/26381451
Autor:
Frédéric Stauffer, Jean-Michel Rondeau, Simona Cotesta, Jonathan Green, Rene Hemmig, J. Constanze D. Hartwieg, Guido Bold, Andreas Marzinzik, Xavier Pelle, Silvio Ofner, E. Bourgier, Chrystelle Henry, Wolfgang Jahnke, S. Lehmann
Publikováno v:
Angewandte Chemie (International ed. in English). 54(48)
Targeting drugs to their desired site of action can increase their safety and efficacy. Bisphosphonates are prototypical examples of drugs targeted to bone. However, bisphosphonate bone affinity is often considered too strong and cannot be significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a912087c34e094acec2b0ff6e6e3263
https://pubmed.ncbi.nlm.nih.gov/26457482
https://pubmed.ncbi.nlm.nih.gov/26457482
Publikováno v:
Journal of Peptide Science. 9:187-199
The synthesis of heterocyclic compounds containing the 7-membered ring system [1,4]diazepane-2,5-dione is described. The aim of this study was to elaborate the solid phase and solution synthesis of eight representatives of the cyclic scaffold and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::204ee2badc3670099c0623ca9ec2d3e6
https://doi.org/10.1002/psc.445
https://doi.org/10.1002/psc.445