Tumor Infiltrating T Lymphocytes and Apoptosis in Colorectal Cancer

Autor: Manal M S, Youssef, Emma C, Paish, J Clifford, Murray, Naglaa M, Farag, Khaled, Saleh, I O, Ellis

Publikováno v: The Egyptian journal of immunology. 22(1)

Dysfunction of the immune system in colorectal cancer (CRC) can be due to a number of reasons including apoptosis of tumour infiltrating lymphocytes (TILs). The aims of this study was to investigate TILs in colorectal cancer and characterize apoptosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc35ceb0ca4dea414e4df42e425c57ac
https://pubmed.ncbi.nlm.nih.gov/26415369

Selective Inhibition of the Human tie-1 Promoter with Triplex-Forming Oligonucleotides Targeted to Ets Binding Sites

Autor: Charles A. Laughton, Asif Ahmed, Emma L. Daft, J. Clifford Murray, Shakil Ahmad, Peter W. Hewett

Publikováno v: Hewett, P W, Daft, E L, Laughton, C A, Ahmad, S, Ahmed, A & Murray, J C 2006, ' Selective inhibition of the human tie-1 promoter with triplex-forming oligonucleotides targeted to Ets binding sites ', Molecular Medicine, vol. 12, no. 1-3, pp. 8-16 . < http://molmed.org/journal/articles/6/250 >

The Tie receptors (Tie-1 and Tie-2/Tek) are essential for angiogenesis and vascular remodeling/integrity. Tie receptors are up-regulated in tumor-associated endothelium, and their inhibition disrupts angiogenesis and can prevent tumor growth as a con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2eee30ab7098628328788f1533b3fe
https://doi.org/10.2119/2005-00046.hewett

A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy

Autor: S. Moein Moghimi, A. Christy Hunter, Adam Szewczyk, J. Clifford Murray, Peter Symonds, Grazyna Debska

Publikováno v: Molecular Therapy. 11:990-995

Poly(ethylenimine) (PEI) is a cationic macromolecule commonly used in gene transfer/therapy protocols with high transfection efficiency both in vitro and in vivo. PEI is also cytotoxic, but the molecular basis of its cytotoxicity is poorly understood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd2cc129914b7a0f2d92a0baf7d8ffc
https://doi.org/10.1016/j.ymthe.2005.02.010

Colorectal Cancer Cells Induce Lymphocyte Apoptosis by an Endothelial Monocyte-Activating Polypeptide-II-Dependent Mechanism

Autor: Ian Todd, Katherine Rice, R. Adrian Robins, Anna Tiga, J. Clifford Murray, Yee M. Heng, Mary L. Huggins, Wynne Ward, Peter Symonds

Publikováno v: The Journal of Immunology. 172:274-281

Endothelial monocyte-activating polypeptide-II (EMAP-II) was first isolated from cell growth medium conditioned by tumor cells, and is closely related or identical with the p43 component of the mammalian multisynthase complex. In its secreted form, E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4545b23bef5953b5baa3a2fd16c63919
https://doi.org/10.4049/jimmunol.172.1.274

Immunohistochemical Analysis of Endothelial-Monocyte-Activating Polypeptide-II Expression in Vivo

Autor: Maarten Tas, Colin Clelland, Georgina Barnett, Joanne Brown, J. Clifford Murray, Des Powe, Anne Jakobsen

Publikováno v: The American Journal of Pathology. 157:2045-2053

Endothelial-monocyte activating polypeptide (EMAP)-II is a novel molecule with cytokine-like pro-inflammatory properties, inducing procoagulant activity on the surface of endothelial cells and monocyte/macrophages in vitro, as well as up-regulating E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe1148af8ce0e1ad5faf3026aa34efa
https://doi.org/10.1016/s0002-9440(10)64843-2