Zobrazeno 1 - 10
of 1 281
pro vyhledávání: '"J. Clewell"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: ß-chloroprene (2-chloro-1,3-butadiene; CP) causes lung tumors after inhalation exposures in rats and mice. Mice develop these tumors at lower exposures than rats. In rats CP exposures cause depletion of lung glutathione (GSH).Methods:
Externí odkaz:
https://doaj.org/article/58999fb3e0744a04b0c9dfbee0d38f0e
Autor:
Rory P. Conolly, Harvey J. Clewell, Martha M. Moore, Jerry L. Campbell, Wanyun Cheng, R. Robinan Gentry
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: A physiologically based pharmacokinetic (PBPK) model for 3-chloroallyl alcohol (3-CAA) was developed and used to evaluate the design of assays for the in vivo genotoxicity of 3-CAA.Methods: Model development was supported by read across
Externí odkaz:
https://doaj.org/article/d8f7461641fa4ee682ebb9ff72cdf343
Autor:
Chantel I. Nicolas, Matthew W. Linakis, Melyssa S. Minto, Kamel Mansouri, Rebecca A. Clewell, Miyoung Yoon, John F. Wambaugh, Grace Patlewicz, Patrick D. McMullen, Melvin E. Andersen, Harvey J. Clewell III
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Current computational technologies hold promise for prioritizing the testing of the thousands of chemicals in commerce. Here, a case study is presented demonstrating comparative risk-prioritization approaches based on the ratio of surrogate hazard an
Externí odkaz:
https://doaj.org/article/c77f706ac85c49c3bc5d018511b024a1
Autor:
Marjory Moreau, Pankajini Mallick, Marci Smeltz, Saad Haider, Chantel I. Nicolas, Salil N. Pendse, Jeremy A. Leonard, Matthew W. Linakis, Patrick D. McMullen, Rebecca A. Clewell, Harvey J. Clewell, Miyoung Yoon
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
High-throughput (HT) in vitro to in vivo extrapolation (IVIVE) is an integral component in new approach method (NAM)-based risk assessment paradigms, for rapidly translating in vitro toxicity assay results into the context of in vivo exposure. When c
Externí odkaz:
https://doaj.org/article/fcd7d8b3f0a74dc38672d8c4d72eb9ac
Publikováno v:
Environment International, Vol 141, Iss , Pp 105784- (2020)
Exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) has been associated with the occurrence of thyroid disease in some epidemiologic studies. We hypothesized that in a specific epidemiologic study based on the National Heal
Externí odkaz:
https://doaj.org/article/eeae693691e646e1a9882186d1d960ab
Autor:
Rory B, Conolly, Jerry L, Campbell, Harvey J, Clewell, Jeffry, Schroeter, Julia S, Kimbell, P Robinan, Gentry
Publikováno v:
Toxicological Sciences. 191:15-24
Understanding the dose-response for formaldehyde-induced nasal cancer in rats is complicated by (1) the uneven distribution of inhaled formaldehyde across the interior surface of the nasal cavity and, (2) the presence of endogenous formaldehyde (endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde6602d72d410cbfe9162760058e888
https://doi.org/10.1093/toxsci/kfac119
https://doi.org/10.1093/toxsci/kfac119
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219769 (2019)
Mathematical models of the natural history of disease can predict incidence rates based on prevalence data and support simulations of populations where thyroid function affects other aspects of physiology. We developed a Markov chain model of functio
Externí odkaz:
https://doaj.org/article/7982d25cf9b14690a3baffac9d5a42ac
Autor:
Jerry L Campbell, Harvey J Clewell, Cynthia Van Landingham, P Robinan Gentry, Athena M Keene, Michael D Taylor, Melvin E Andersen
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology.
In earlier physiologically based pharmacokinetic (PBPK) models for manganese (Mn), the kinetics of transport of Mn into and out of tissues were primarily driven by slow rates of association and dissociation of Mn with tissue binding sites. However, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ef7816aef3f1c7f85d4097bbbdfcd0
https://pubmed.ncbi.nlm.nih.gov/36453847
https://pubmed.ncbi.nlm.nih.gov/36453847
Autor:
Jenny M Pedersen, Yoo-Sik Shim, Vaibhav Hans, Martin Blake Phillips, Jeffrey M. Macdonald, Glenn Walker, Melvin E. Andersen, Harvey J. Clewell, Miyoung Yoon
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 4 (2016)
Accurate prediction of metabolism is a significant outstanding challenge in toxicology. The best predictions are based on experimental data from in vitro systems using primary hepatocytes. The predictivity of the primary hepatocyte-based culture syst
Externí odkaz:
https://doaj.org/article/88ed7d6f48f94a27a7855aeae14a7820
Autor:
Jean Lou C. M. Dorne, Bernard Bottex, Caroline Merten, Andrea Germini, Nikolaos Georgiadis, Elisa Aiassa, Laura Martino, Lorenz Rhomberg, Harvey J. Clewell, Matthias Greiner, Glenn W. Suter, Maurice Whelan, Andrew D. M. Hart, Derek Knight, Prabhat Agarwal, Maged Younes, Jan Alexander, Anthony R. Hardy
Publikováno v:
EFSA Journal, Vol 14, Iss S1, Pp n/a-n/a (2016)
Abstract Methodologies for integrating (weighing) evidence and assessing uncertainties are of utmost importance to ensure that scientific assessments are transparent, robust and fit for purpose to support decision‐makers. One of the key challenges
Externí odkaz:
https://doaj.org/article/51940e5540644bbb9b900249892af331