Zobrazeno 1 - 10
of 262
pro vyhledávání: '"J. Clemons"'
Autor:
Swati Dawar, Mariana C. Benitez, Yoon Lim, Toby A. Dite, Jumana M. Yousef, Niko Thio, Sylvain Garciaz, Thomas D. Jackson, Julia V. Milne, Laura F. Dagley, Wayne A. Phillips, Sharad Kumar, Nicholas J. Clemons
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-12 (2024)
Abstract Caspase-2, one of the most evolutionarily conserved members of the caspase family, is an important regulator of the cellular response to oxidative stress. Given that ferroptosis is suppressed by antioxidant defense pathways, such as that inv
Externí odkaz:
https://doaj.org/article/c7b62275bdf5491087ff5cffc8820630
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Currently, esophageal adenocarcinoma (EAC) research is hindered by a dearth of adequate models to study this disease. Traditional cell line and genetically engineered mouse models are lacking in biological and physiological significance, whilst the i
Externí odkaz:
https://doaj.org/article/d45d9098d11a4110ba52edd7447fc3a4
Autor:
Francesc de Las Heras, Camilla B Mitchell, William K Murray, Nicholas J Clemons, Wayne A Phillips
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0308051 (2024)
Preclinical models that replicate patient tumours as closely as possible are crucial for translational cancer research. While in vitro cancer models have many advantages in assessing tumour response therapy, in vivo systems are essential to enable ev
Externí odkaz:
https://doaj.org/article/aad2ee58456447df8453555b80848898
Autor:
Donna J. Clemons, Jennifer L. Seeman
Laboratory animals play an important role in biomedical research and advances. Expanded, updated, and now published in full color to provide greater clarity to the techniques and concepts discussed, this guide presents basic information and common pr
Autor:
Sophia Ceder, Sofi E. Eriksson, Ying Yu Liang, Emarndeena H. Cheteh, Si Min Zhang, Kenji M. Fujihara, Julie Bianchi, Vladimir J. N. Bykov, Lars Abrahmsen, Nicholas J. Clemons, Pär Nordlund, Sean G. Rudd, Klas G. Wiman
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Abstract Asparaginase depletes extracellular asparagine in the blood and is an important treatment for acute lymphoblastic leukemia (ALL) due to asparagine auxotrophy of ALL blasts. Unfortunately, resistance occurs and has been linked to expression o
Externí odkaz:
https://doaj.org/article/b2b5eed6ca834936815c57813c137b8e
Autor:
Vincent T. Janmaat, Kateryna Nesteruk, Manon C. W. Spaander, Auke P. Verhaar, Bingting Yu, Rodrigo A. Silva, Wayne A. Phillips, Marcin Magierowski, Anouk van de Winkel, H. Scott Stadler, Tatiana Sandoval-Guzmán, Luc J. W. van der Laan, Ernst J. Kuipers, Ron Smits, Marco J. Bruno, Gwenny M. Fuhler, Nicholas J. Clemons, Maikel P. Peppelenbosch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Barrett’s esophagus is a pro-oncogenic lesion in the proximal gastrointestinal tract, but with a distal colon-like morphology. Here the authors report that the distal HOX gene HOXA13 is expressed in Barrett’s esophagus and in single cells of the
Externí odkaz:
https://doaj.org/article/469f4cbf24264d01b938927512f6b9a2
Autor:
Julia V. Milne, Bonnie Z. Zhang, Kenji M. Fujihara, Swati Dawar, Wayne A. Phillips, Nicholas J. Clemons
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The prevalence and dire implications of mutations in the tumour suppressor, p53, highlight its appeal as a chemotherapeutic target. We recently showed that impairing cellular antioxidant systems via inhibition of SLC7A11, a component of the
Externí odkaz:
https://doaj.org/article/ba9b4fb88cd4428c8a2cf11039b060f4
Autor:
Jovana R. Gotovac, Tanjina Kader, Julia V. Milne, Kenji M. Fujihara, Luis E. Lara-Gonzalez, Kylie L. Gorringe, Sangeetha N. Kalimuthu, Madawa W. Jayawardana, Cuong P. Duong, Wayne A. Phillips, Nicholas J. Clemons
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 689-713 (2021)
Background & Aims: Esophageal adenocarcinoma (EAC) develops from its precursor Barrett’s esophagus through intermediate stages of low- and high-grade dysplasia. However, knowledge of genetic drivers and molecular mechanisms implicated in disease pr
Externí odkaz:
https://doaj.org/article/a7e5902c1bfa452b8729ab028422f939
Autor:
Jeffrey Molendijk, Cathryn M. Kolka, Henry Cairns, Sandra Brosda, Ahmed Mohamed, Alok K. Shah, Ian Brown, Mark P. Hodson, Thomas Hennessy, Guanghao Liu, Thomas Stoll, Renee S. Richards, Michael Gartside, Kalpana Patel, Nicholas J. Clemons, Wayne A. Phillips, Andrew Barbour, Johan A. Westerhuis, Michelle M. Hill
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 5, Pp n/a-n/a (2022)
Abstract Background The risk of esophageal adenocarcinoma (EAC) is associated with gastro‐esophageal reflux disease (GERD) and obesity. Lipid metabolism‐targeted therapies decrease the risk of progressing from Barrett's esophagus (BE) to EAC, but
Externí odkaz:
https://doaj.org/article/83267b7d1c744d739752ec479435fbf3
Autor:
Sophia Ceder, Sofi E Eriksson, Emarndeena H Cheteh, Swati Dawar, Mariana Corrales Benitez, Vladimir J N Bykov, Kenji M Fujihara, Mélodie Grandin, Xiaodun Li, Susanne Ramm, Corina Behrenbruch, Kaylene J Simpson, Frédéric Hollande, Lars Abrahmsen, Nicholas J Clemons, Klas G Wiman
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-20 (2020)
Abstract The tumor suppressor gene TP53 is the most frequently mutated gene in cancer. The compound APR‐246 (PRIMA‐1Met/Eprenetapopt) is converted to methylene quinuclidinone (MQ) that targets mutant p53 protein and perturbs cellular antioxidant
Externí odkaz:
https://doaj.org/article/ad163b956af24ac198adeee8afcb4f6a