Zobrazeno 1 - 10
of 15
pro vyhledávání: '"J. Claire Godbersen"'
Autor:
Alexey V. Danilov, Alan Eastman, Jennifer R. Brown, Peter E. Kebbekus, Olga V. Danilova, Leigh Ann Humphries, J. Claire Godbersen
MLN4924 does not impair stroma viability or CD40L expression. Stromal cells were seeded in a 96 well plate at 5x104 cells/well and the next day treated with the indicated concentrations of MLN4924 in triplicate for 48 hours. Cell lysates were subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bcd01e553ef5440fce0f06ca1d1c667
https://doi.org/10.1158/1078-0432.22451249.v1
https://doi.org/10.1158/1078-0432.22451249.v1
Autor:
Alexey V. Danilov, Alan Eastman, Jennifer R. Brown, Peter E. Kebbekus, Olga V. Danilova, Leigh Ann Humphries, J. Claire Godbersen
PDF file - 123KB, Effect of MLN4924 on Bim expression in CLL. CLL cells were co-cultured with CD40L-expressing stroma for 24 hours, followed by incubation with 1 microM MLN4924 or vehicle control. Cell were lysed at 24 hours and subjected to immunobl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5232a484ffcaa1902026c4ee6de0dd5d
https://doi.org/10.1158/1078-0432.22451219.v1
https://doi.org/10.1158/1078-0432.22451219.v1
Autor:
Alexey V. Danilov, Alan Eastman, Jennifer R. Brown, Peter E. Kebbekus, Olga V. Danilova, Leigh Ann Humphries, J. Claire Godbersen
PDF file - 174KB, siRNA-mediated knockdown of Noxa and Puma results in a decrease in corresponding transcript levels. CLL cells (N=4) were transfected with two individual siRNA's against Noxa, a Puma-targeting siRNA or control siRNA using Amaxa progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023405d3b66b7c1c649047adb550ece0
https://doi.org/10.1158/1078-0432.22451225.v1
https://doi.org/10.1158/1078-0432.22451225.v1
Autor:
Alexey V. Danilov, Alan Eastman, Jennifer R. Brown, Peter E. Kebbekus, Olga V. Danilova, Leigh Ann Humphries, J. Claire Godbersen
PDF file - 74KB, MLN4924 leads to downregulation of NFkappaB activity in a dose-dependent manner. (A) MLN4924 leads to downregulation of CXCR5 in CLL. CLL cells (N=9) were co-cultured with CD40L-expressing stroma for 24 hours, followed by incubation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071d9afd097707e11d11762c69e72d5a
https://doi.org/10.1158/1078-0432.22451234.v1
https://doi.org/10.1158/1078-0432.22451234.v1
Autor:
Alexey V. Danilov, Alan Eastman, Jennifer R. Brown, Peter E. Kebbekus, Olga V. Danilova, Leigh Ann Humphries, J. Claire Godbersen
PDF file - 69KB, MLN4924-induces apoptosis of the CLL B-cells on CD40L-expressing stroma is independent of IGHV mutational status (A) and cytogenetics (B, C). CLL cells were cultured on CD40L-expressing stroma for 24 hours, followed by incubation wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4666f04fd26fc01164b8ff3a29ff17
https://doi.org/10.1158/1078-0432.22451255.v1
https://doi.org/10.1158/1078-0432.22451255.v1
Autor:
Alexey V. Danilov, Alan Eastman, Jennifer R. Brown, Peter E. Kebbekus, Olga V. Danilova, Leigh Ann Humphries, J. Claire Godbersen
PDF file - 107KB, MLN4924-induced apoptosis is accompanied by loss of canonical NFkappaB activation. CLL cells were co-cultured with CD40L-expressing stroma for 24 hours in the presence or absence of 10 ng/ml IL4. Thereafter, cell were incubated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119d88562cbf9df70d5b34ac03c7591b
https://doi.org/10.1158/1078-0432.22451240.v1
https://doi.org/10.1158/1078-0432.22451240.v1
Autor:
Alexey V. Danilov, Alan Eastman, Jennifer R. Brown, Peter E. Kebbekus, Olga V. Danilova, Leigh Ann Humphries, J. Claire Godbersen
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b18596878139272c220a3afef224524
https://doi.org/10.1158/1078-0432.22451213
https://doi.org/10.1158/1078-0432.22451213
Autor:
Alexey V. Danilov, Alan Eastman, Jennifer R. Brown, Peter E. Kebbekus, Olga V. Danilova, Leigh Ann Humphries, J. Claire Godbersen
PDF file - 59KB, BMS-345541 leads to Bim upregulation in CLL. CLL cells (N=3) were co-cultured with CD40L-expressing stroma for 24 hours, followed by incubation with 2 - 12 microM BMS-345541 or vehicle control for 24 h. Cells were lysed and subjected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d65ec815d663293c909dbbf196acae
https://doi.org/10.1158/1078-0432.22451228
https://doi.org/10.1158/1078-0432.22451228
Autor:
Alexey V. Danilov, Alan Eastman, Jennifer R. Brown, Peter E. Kebbekus, Olga V. Danilova, Leigh Ann Humphries, J. Claire Godbersen
Background: Stromal-mediated signaling enhances NF-κB pathway activity in chronic lymphocytic leukemia (CLL) B cells, leading to cell survival and chemoresistance. Ubiquitination of IκBα may partially account for constitutive activation of NF-κB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f056f9f51e1dcad1d015ba7dab476b9
https://doi.org/10.1158/1078-0432.c.6522128
https://doi.org/10.1158/1078-0432.c.6522128
Autor:
Cody Paiva, J Claire Godbersen, Ryan S Soderquist, Taylor Rowland, Sumner Kilmarx, Stephen E Spurgeon, Jennifer R Brown, Sreesha P Srinivasa, Alexey V Danilov
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143685 (2015)
CDK (cyclin-dependent kinase) inhibitors have shown remarkable activity in CLL, where its efficacy has been linked to inhibition of the transcriptional CDKs (7 and 9) and deregulation of RNA polymerase and short-lived pro-survival proteins such as MC
Externí odkaz:
https://doaj.org/article/76cdc642921945679fd81474213b76e4