Zobrazeno 1 - 10
of 34
pro vyhledávání: '"J. Christopher Gorski"'
Autor:
Stephen D. Hall, Srikar R. Malireddy, Raj Vuppalanchi, Mitchell A. Hamman, Sara K. Quinney, Naga Chalasani, J. Christopher Gorski
Publikováno v:
European Journal of Clinical Pharmacology. 69:439-448
To determine the extent and time-course of hepatic and intestinal cytochrome P450 3A (CYP3A) inactivation due to the mechanism-based inhibitor clarithromycin.Intestinal and hepatic CYP3A inhibition was examined in 12 healthy volunteers following the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf701fbf113e50d483494384324be6a8
https://doi.org/10.1007/s00228-012-1339-x
https://doi.org/10.1007/s00228-012-1339-x
Publikováno v:
The Journal of Clinical Pharmacology. 51:575-585
Drug interactions are a significant clinical concern, particularly in patients with conditions such as heart disease and hypertension, in whom coadministration of multiple drugs is common. Nebivolol is a selective β(1)-blocker with vasodilatory prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f51d39fba183af3d25ed34807629dac
https://doi.org/10.1177/0091270010370846
https://doi.org/10.1177/0091270010370846
Physiologically Based Pharmacokinetic Model of Mechanism-Based Inhibition of CYP3A by Clarithromycin
Autor:
Lang Li, Aroonrut Lucksiri, J. Christopher Gorski, Xin Zhang, Sara K. Quinney, Stephen D. Hall
Publikováno v:
Drug Metabolism and Disposition. 38:241-248
The prediction of clinical drug-drug interactions (DDIs) due to mechanism-based inhibitors of CYP3A is complicated when the inhibitor itself is metabolized by CYP3Aas in the case of clarithromycin. Previous attempts to predict the effects of clarithr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f4e5163ccd1208328cfe7cdbfbb949
https://doi.org/10.1124/dmd.109.028746
https://doi.org/10.1124/dmd.109.028746
Autor:
Aroonrut Lucksiri, Steven A. Wrighton, Charles S. Ernest, Jenny Y. Chien, Stephen D. Hall, J. Christopher Gorski
Publikováno v:
Drug Metabolism and Disposition. 34:1208-1219
Conventional methods to forecast CYP3A-mediated drug-drug interactions have not employed stochastic approaches that integrate pharmacokinetic (PK) variability and relevant covariates to predict inhibition in terms of probability and uncertainty. Empi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1b38fed5647e53a3c28ad1a9ec1793
https://doi.org/10.1124/dmd.105.008730
https://doi.org/10.1124/dmd.105.008730
Autor:
Stephen D. Hall, Mitchell A. Hamman, Narjis A. Zaheer, Zaiqi Wang, G. L. Lemma, J. Christopher Gorski
Publikováno v:
Clinical Pharmacology & Therapeutics. 79:218-230
Background Verapamil has the capability to inhibit and induce cytochrome P450 (CYP) 3A and P-glycoprotein (P-gp), but the relative extent and time course of these events in vivo are unclear. The effect of verapamil on CYP3A and P-gp activity was dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64003fd6ef9e7e3bf65a1491b6a034f5
https://doi.org/10.1016/j.clpt.2005.11.001
https://doi.org/10.1016/j.clpt.2005.11.001
Publikováno v:
Drug Metabolism and Disposition. 33:1052-1055
Dextromethorphan urinary metabolic ratio is widely used to determine the CYP2D6 phenotype, but its utility to reflect subtle differences in catalytic activity is unclear. We evaluated the capability of dextromethorphan urinary metabolic ratio to pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7b7376af0ca4df57d7f0f093775299
https://doi.org/10.1124/dmd.104.003459
https://doi.org/10.1124/dmd.104.003459
Autor:
David A. Flockhart, Stephen D. Hall, A. Q. Adigun, Naga Chalasani, Amar G. Pinto, J. Christopher Gorski, Lang Li
Publikováno v:
The American Journal of Cardiology. 95:691-694
The effect of gender on the QT interval in patients with cirrhosis before and after liver transplantation and the relation between the QT interval and changes in gender hormones after liver transplantation were assessed. The study showed that (1) phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e0e87140f212dd92c4db4305ff1f37
https://doi.org/10.1016/j.amjcard.2004.10.054
https://doi.org/10.1016/j.amjcard.2004.10.054
Autor:
Suthat Liangpunsakul, Naga Chalasani, Stephen D. Hall, Amar G. Pinto, J. Christopher Gorski, Dhanashri Kolwankar
Publikováno v:
Hepatology. 41:1144-1150
Alcohol consumption is known to induce hepatic CYP2E1 activity, but its effect on hepatic and intestinal CYP3A in humans is not known. We have conducted a study to compare the CYP2E1 and CYP3A activities in 20 individuals with moderate alcohol consum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b7fea162fc8d7516485a2347c16910
https://doi.org/10.1002/hep.20673
https://doi.org/10.1002/hep.20673
Autor:
Sheldon H. Preskorn, Steve Werder, Anne T. Harvey, David J. Greenblatt, Michael J. Burke, J. Christopher Gorski, David A. Flockhart
Publikováno v:
The Journal of Clinical Pharmacology. 44:1173-1184
The objective of this study was to estimate the effects of intramuscular haloperidol and lorazepam on the QT interval in volunteers with schizophrenia. Intramuscular haloperidol and intramuscular lorazepam are standard treatments in the acute managem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f53be88ece7c2abd6e493f941f0b19
https://doi.org/10.1177/0091270004267807
https://doi.org/10.1177/0091270004267807
Autor:
Stephen D. Hall, A. Q. Adigun, Nina Vasavada, Shiew-Mei Huang, J. Christopher Gorski, Zaiqi Wang, Mitchell A. Hamman, J. Hilligoss, Margaret Miller
Publikováno v:
Clinical Pharmacology & Therapeutics. 74:525-535
The popular herbal remedy St John's wort is an inducer of cytochrome P450 (CYP) 3A enzymes and may reduce the efficacy of oral contraceptives. Therefore we evaluated the effect of St John's wort on the disposition and efficacy of Ortho-Novum 1/35 (Or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb15d788ce89611929f314540f04d95
https://doi.org/10.1016/j.clpt.2003.08.009
https://doi.org/10.1016/j.clpt.2003.08.009