Zobrazeno 1 - 10
of 675
pro vyhledávání: '"J. Chory"'
Autor:
Emma J. Chory, Meng Wang, Michele Ceribelli, Aleksandra M Michalowska, Stefan Golas, Erin Beck, Carleen Klumpp-Thomas, Lu Chen, Crystal McKnight, Zina Itkin, Kelli M. Wilson, David Holland, Sanjay Divakaran, James Bradner, Javed Khan, Berkley E. Gryder, Craig J. Thomas, Benjamin Z. Stanton
Publikováno v:
SLAS Discovery, Vol 28, Iss 4, Pp 193-201 (2023)
ABSTRACT: We report a comprehensive drug synergy study in acute myeloid leukemia (AML). In this work, we investigate a panel of cell lines spanning both MLL-rearranged and non-rearranged subtypes. The work comprises a resource for the community, with
Externí odkaz:
https://doaj.org/article/666943293cc94a44bc30dbda4865e32e
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 3, Pp n/a-n/a (2021)
Abstract Our understanding of complex living systems is limited by our capacity to perform experiments in high throughput. While robotic systems have automated many traditional hand‐pipetting protocols, software limitations have precluded more adva
Externí odkaz:
https://doaj.org/article/c41ab37745d3457197e8dc0015561630
Autor:
Simon M. G. Braun, Jacob G. Kirkland, Emma J. Chory, Dylan Husmann, Joseph P. Calarco, Gerald R. Crabtree
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Understanding the link between epigenetic marks and gene regulation requires the development of new tools to directly manipulate chromatin. Here the authors demonstrate a Cas9-based system to recruit chromatin remodelers to loci of interest, allowing
Externí odkaz:
https://doaj.org/article/ceb7020dd5784ed49c21a33809ac7893
Autor:
Emma J. Chory, Meng Wang, Michele Ceribelli, Aleksandra M Michalowska, Stefan Golas, Erin Beck, Carleen Klumpp-Thomas, Lu Chen, Crystal McKnight, Zina Itkin, Sanjay Divakaran, James Bradner, Javed Khan, Berkley E. Gryder, Craig J. Thomas, Benjamin Z. Stanton
We report a comprehensive drug synergy study in acute myeloid leukemia (AML). In this work, we investigate 11 cell lines spanning both MLL-rearranged and non-rearranged subtypes. The work comprises a resource for the community, with many synergistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0abda83e59ba78d1516587230f156cfc
https://doi.org/10.1101/2022.11.29.518409
https://doi.org/10.1101/2022.11.29.518409
Autor:
Xiao Tan, F Ann Ran, Nathaniel D. Tippens, James J. Collins, Emma J. Chory, Evan M. Zhao, Crystal Yuri Oh, Angelo S. Mao, Eric S Zigon, Tiffany Y Hua, Kehan Zhang, Pradeep Ramesh, David B. Thompson, Peter Q. Nguyen, Isaac Han, Max A English, Helena de Puig
Publikováno v:
Nature Biotechnology. 40:539-545
The ability to control translation of endogenous or exogenous RNAs in eukaryotic cells would facilitate a variety of biotechnological applications. Current strategies are limited by low fold changes in transgene output and the size of trigger RNAs (t
Autor:
Jason J. Keleher, Alexis D. Ostrowski, Amie E. Norton, Giuseppe E. Giammanco, M H Jayan S Karunarathna, Jackson J. Chory, Abigail N. Linhart
Publikováno v:
ACS Applied Bio Materials. 4:5765-5775
Coordination of Fe(III) to carboxylates in polyuronic acid hydrogels was used to impart photochemical reactivity to polysaccharide-based hydrogels. This photochemical reaction was then used for light-initiated polymerization to create hydrogels with
Akademický článek
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Akademický článek
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Autor:
Evan M, Zhao, Angelo S, Mao, Helena, de Puig, Kehan, Zhang, Nathaniel D, Tippens, Xiao, Tan, F Ann, Ran, Isaac, Han, Peter Q, Nguyen, Emma J, Chory, Tiffany Y, Hua, Pradeep, Ramesh, David B, Thompson, Crystal Yuri, Oh, Eric S, Zigon, Max A, English, James J, Collins
Publikováno v:
Nature biotechnology. 40(4)
The ability to control translation of endogenous or exogenous RNAs in eukaryotic cells would facilitate a variety of biotechnological applications. Current strategies are limited by low fold changes in transgene output and the size of trigger RNAs (t
Autor:
Erika A. DeBenedictis, Emma J. Chory, Dana W. Gretton, Brian Wang, Stefan Golas, Kevin M. Esvelt
Publikováno v:
Nature methods. 19(1)
Evolution occurs when selective pressures from the environment shape inherited variation over time. Within the laboratory, evolution is commonly used to engineer proteins and RNA, but experimental constraints have limited the ability to reproducibly